ID
45602
Descrição
Principal Investigator: Jiyoung Ahn, PhD, Department of Population Health, NYU School of Medicine, NY, USA MeSH: Colonic Polyps,Adenomatous Polyps https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001381 Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma and the serrated polyp. This dataset was used to test the relationship of the gut microbiota to specific colorectal polyp types. We included samples from two independent study populations based at colonoscopy clinics: the Centers for Disease Control and Prevention (CDC) Study of In-home Tests for Colorectal Cancer (SIT), and the New York University (NYU) Human Microbiome and Colorectal Tumor study. Gut microbiota were assessed in 667 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples, of which 540 were included in our analysis. Participants were categorized as conventional adenoma cases, serrated polyp cases, or polyp-free controls. CA cases were further classified as proximal or distal and as non-advanced or advanced. Serrated polyp cases were further classified as hyperplastic polyp or sessile serrated adenoma. Our results show associations between gut microbiome composition and presence of conventional adenomas, including reduced diversity and alterations in taxon abundance.
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Versões (1)
- 15/02/2023 15/02/2023 - Chiara Middel
Titular dos direitos
Jiyoung Ahn, PhD, Department of Population Health, NYU School of Medicine, NY, USA
Transferido a
15 février 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001381 Gut Microbiome and Types of Colorectal Polyps
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
- Subject ID, sample ID, and sample use variable obtained from participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
- Subject ID, study, sex, race, age, familial polyposis, participant Crohn disease, ulcerative colitis, and gastrointestinal cancer, colonoscopy, anastomosis, carcinoid, inflammatory bowel disease, polyp(s), blood in stool or rectal bleeding, normal/non-polyp histology, sessile serrated adenoma(s), tubular adenoma(s), and tubulovillous adenoma of participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
- Sample ID, analyte type, body site where sample was obtained, and tumor status of participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
- Subject ID, sample ID, and sample use variable obtained from participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
- Subject ID, study, sex, race, age, familial polyposis, participant Crohn disease, ulcerative colitis, and gastrointestinal cancer, colonoscopy, anastomosis, carcinoid, inflammatory bowel disease, polyp(s), blood in stool or rectal bleeding, normal/non-polyp histology, sessile serrated adenoma(s), tubular adenoma(s), and tubulovillous adenoma of participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
- Sample ID, analyte type, body site where sample was obtained, and tumor status of participants with or without colorectal polyps and involved in the "Gut Microbiome and Types of Colorectal Polyps" project.
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