ID

45601

Descrizione

Principal Investigator: Patrick F. Sullivan, University of North Carolina, Chapel Hill, NC, USA MeSH: Major Depressive Disorder https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000658 Sub-study QI: 941 cases of Major Depressive Disorder (MDD) from the Queensland Institute of Medical Research (QIMR), Australia Sub-study VU: 127 MDD cases from The Netherlands Study of Anxiety and Depression (NESDA) (http://www.nesda.nl) and The Netherlands Twin Registry (NTR) (http://www.tweelingenregister.org) based at the VU Amsterdam, The Netherlands. Sub-study ED: 373 MDD cases from the University of Edinburgh, UK.

collegamento

dbGaP-study=phs000658

Keywords

versioni (1)
  1. 14/02/23 14/02/23 - Chiara Middel
Titolare del copyright

Patrick F. Sullivan, University of North Carolina, Chapel Hill, NC, USA

Caricato su

14 febbraio 2023

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
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dbGaP phs000658 MDD2000AFFY

Inglese

Eligibility Criteria

5 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Sub-study QI:* Study participants were adult twins and their families recruited through the Australian Twin Registry (http://www.twins.org.au) at the Queensland Institute of Medical Research (QIMR). Only unrelated individuals were included in MDD2000AFFY. MDD cases were identified through psychiatric questionnaires, either the shortened Composite International Diagnostic Interview or, for the majority (94%), through the SSAGA-OZ interview instrument (a version of the Semi-Structured Assessment for the Genetics of Alcoholism modified for use in Australia), a comprehensive psychiatric interview designed to assess MDD and other psychiatric disorders according to DSM-IIIR and DSM-IV criteria. Structured interviews were administered by trained telephone interviewers, closely supervised by a clinical psychologist. Briefly, from 1988 to 1990, study participants were mailed an extensive health and lifestyle questionnaire, which included the shortened revised Eysenck personality questionnaire. Sum scores of 12 item responses in each personality domain resulted in quantitative scores for neuroticism. Between 1992-2000, an unselected subset of these participants were interviewed by telephone using the SSAGA-OZ. Over the period 1996-1999 sibling pairs that were either concordant or discordant for extreme neuroticism scores (one sibling in the top or bottom decile, the other sibling in the top or bottom quintile) were recruited to complete the Composite International Diagnostic Interview, which provides DSM-IV lifetime diagnoses of MDD. Finally, some study participants completed the SSAGA-OZ telephone questionnaire in 2003-2007 as part of alcohol and nicotine dependence studies. Screening items for mania were not consistent across interviews and screening items for psychosis were not included; the ability to assess accurately these less common criteria is difficult in large-scale community settings. Therefore, it is possible that a small number of individuals with a primary diagnosis of bipolar disorder or schizophrenia are included in the case group. Some participants may be the same or relatives of those in the OZ-ALC study (dbGaP phs000181.v1.p1).
Descrizione

Elig.phs000658.v1.p1.1

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0242800
UMLS CUI [1,2]
C0041427
UMLS CUI [1,3]
C0030761
UMLS CUI [1,4]
C0015576
UMLS CUI [1,5]
C0034975
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0030705
UMLS CUI [2,3]
C1546988
UMLS CUI [3,1]
C1269683
UMLS CUI [3,2]
C0205396
UMLS CUI [3,3]
C0846574
UMLS CUI [3,4]
C0034394
UMLS CUI [3,5]
C0220952
UMLS CUI [3,6]
C0679229
UMLS CUI [3,7]
C0683844
UMLS CUI [3,8]
C0039457
UMLS CUI [3,9]
C0021821
UMLS CUI [3,10]
C0870294
UMLS CUI [3,11]
C0237412
UMLS CUI [4,1]
C1948053
UMLS CUI [4,2]
C0024492
UMLS CUI [4,3]
C1879301
UMLS CUI [4,4]
C0392762
UMLS CUI [4,5]
C2964552
UMLS CUI [4,6]
C1842981
UMLS CUI [5,1]
C1948053
UMLS CUI [5,2]
C1515021
UMLS CUI [5,3]
C0039457
UMLS CUI [5,4]
C0021821
UMLS CUI [5,5]
C0034394
UMLS CUI [6,1]
C1948053
UMLS CUI [6,2]
C0037047
UMLS CUI [6,3]
C4553529
UMLS CUI [6,4]
C0205403
UMLS CUI [6,5]
C1842981
UMLS CUI [6,6]
C2964552
UMLS CUI [6,7]
C0451085
UMLS CUI [6,8]
C1269683
UMLS CUI [6,9]
C0220952
UMLS CUI [7,1]
C1948053
UMLS CUI [7,2]
C0037047
UMLS CUI [7,3]
C1298908
UMLS CUI [7,4]
C4553529
UMLS CUI [7,5]
C0205403
UMLS CUI [7,6]
C1842981
UMLS CUI [7,7]
C2964552
UMLS CUI [7,8]
C0451085
UMLS CUI [7,9]
C1269683
UMLS CUI [7,10]
C0220952
UMLS CUI [8,1]
C1948053
UMLS CUI [8,2]
C0039457
UMLS CUI [8,3]
C0034394
UMLS CUI [8,4]
C0038580
UMLS CUI [8,5]
C0028043
UMLS CUI [8,6]
C0085762
UMLS CUI [9,1]
C0220908
UMLS CUI [9,2]
C0024713
UMLS CUI [9,3]
C0442809
UMLS CUI [9,4]
C0021822
UMLS CUI [10,1]
C1298908
UMLS CUI [10,2]
C1512693
UMLS CUI [10,3]
C0220908
UMLS CUI [10,4]
C0033975
UMLS CUI [11,1]
C0332149
UMLS CUI [11,2]
C1512693
UMLS CUI [11,3]
C0030705
UMLS CUI [11,4]
C0024713
UMLS CUI [11,5]
C0033975
UMLS CUI [11,6]
C1698493
*Sub-study VU:* These samples do not overlap with those included in a prior MDD GWAS (PMID: 19065144, dbGaP: phs000020.v2.p1) but are drawn from the same parent studies (and include a small number of related individuals). Similar inclusion and exclusion criteria were used to select MDD cases from both the NESDA and NTR studies. Inclusion criteria were a lifetime diagnosis of DSM-IV MDD as determined by the Composite International Diagnostic Interview, age 18-65 years, and self-reported western European ancestry. Those not fluent in Dutch or with a primary diagnosis of schizophrenia.
Descrizione

Elig.phs000658.v1.p1.2

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1298908
UMLS CUI [1,2]
C1948020
UMLS CUI [1,3]
C0205156
UMLS CUI [1,4]
C0947630
UMLS CUI [2,1]
C0807980
UMLS CUI [2,2]
C0445247
UMLS CUI [2,3]
C0030551
UMLS CUI [2,4]
C0947630
UMLS CUI [3,1]
C1512693
UMLS CUI [3,2]
C0011900
UMLS CUI [3,3]
C4071830
UMLS CUI [3,4]
C1269683
UMLS CUI [3,5]
C0220952
UMLS CUI [3,6]
C0001779
UMLS CUI [3,7]
C2700446
UMLS CUI [3,8]
C1257905
UMLS CUI [4,1]
C0680251
UMLS CUI [4,2]
C1299585
UMLS CUI [4,3]
C0564215
UMLS CUI [4,4]
C0376241
UMLS CUI [4,5]
C0205225
UMLS CUI [4,6]
C0011900
UMLS CUI [4,7]
C0036341
*Sub-study ED:* MDD cases were recruited through in- and out-patient services of psychiatric hospitals in Scotland and were tertiary referrals from primary care. All patients were interviewed by an experienced psychiatrist using the Schedule for Affective Disorders and Schizophrenia-Lifetime, supplemented by hospital case note review and information from informants. Final determination of MDD as the primary DSM-IV diagnosis was made by consensus of two psychiatrists. All cases had a lifetime history of recurrent MDD and IQ > 70. No phenotypic data other than diagnosis and sex are available for this cohort.
Descrizione

Elig.phs000658.v1.p1.3

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0242800
UMLS CUI [1,2]
C1269683
UMLS CUI [1,3]
C0020021
UMLS CUI [1,4]
C0036453
UMLS CUI [1,5]
C0205372
UMLS CUI [1,6]
C0034927
UMLS CUI [1,7]
C0033131
UMLS CUI [2,1]
C0021822
UMLS CUI [2,2]
C0033872
UMLS CUI [2,3]
C1524063
UMLS CUI [2,4]
C0683462
UMLS CUI [2,5]
C3842891
UMLS CUI [3,1]
C1546485
UMLS CUI [3,2]
C1269683
UMLS CUI [3,3]
C0332137
UMLS CUI [3,4]
C0220952
UMLS CUI [3,5]
C0376298
UMLS CUI [3,6]
C0205448
UMLS CUI [3,7]
C0033872
UMLS CUI [4,1]
C4071830
UMLS CUI [4,2]
C0262926
UMLS CUI [4,3]
C1269683
UMLS CUI [5,1]
C1298908
UMLS CUI [5,2]
C0031437
UMLS CUI [5,3]
C1511726
UMLS CUI [5,4]
C0332300
UMLS CUI [5,5]
C0011900
UMLS CUI [5,6]
C0079399
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Similar models

Eligibility Criteria

5 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs000658.v1.p1.1
Item
*Sub-study QI:* Study participants were adult twins and their families recruited through the Australian Twin Registry (http://www.twins.org.au) at the Queensland Institute of Medical Research (QIMR). Only unrelated individuals were included in MDD2000AFFY. MDD cases were identified through psychiatric questionnaires, either the shortened Composite International Diagnostic Interview or, for the majority (94%), through the SSAGA-OZ interview instrument (a version of the Semi-Structured Assessment for the Genetics of Alcoholism modified for use in Australia), a comprehensive psychiatric interview designed to assess MDD and other psychiatric disorders according to DSM-IIIR and DSM-IV criteria. Structured interviews were administered by trained telephone interviewers, closely supervised by a clinical psychologist. Briefly, from 1988 to 1990, study participants were mailed an extensive health and lifestyle questionnaire, which included the shortened revised Eysenck personality questionnaire. Sum scores of 12 item responses in each personality domain resulted in quantitative scores for neuroticism. Between 1992-2000, an unselected subset of these participants were interviewed by telephone using the SSAGA-OZ. Over the period 1996-1999 sibling pairs that were either concordant or discordant for extreme neuroticism scores (one sibling in the top or bottom decile, the other sibling in the top or bottom quintile) were recruited to complete the Composite International Diagnostic Interview, which provides DSM-IV lifetime diagnoses of MDD. Finally, some study participants completed the SSAGA-OZ telephone questionnaire in 2003-2007 as part of alcohol and nicotine dependence studies. Screening items for mania were not consistent across interviews and screening items for psychosis were not included; the ability to assess accurately these less common criteria is difficult in large-scale community settings. Therefore, it is possible that a small number of individuals with a primary diagnosis of bipolar disorder or schizophrenia are included in the case group. Some participants may be the same or relatives of those in the OZ-ALC study (dbGaP phs000181.v1.p1).
boolean
C0242800 (UMLS CUI [1,1])
C0041427 (UMLS CUI [1,2])
C0030761 (UMLS CUI [1,3])
C0015576 (UMLS CUI [1,4])
C0034975 (UMLS CUI [1,5])
C1512693 (UMLS CUI [2,1])
C0030705 (UMLS CUI [2,2])
C1546988 (UMLS CUI [2,3])
C1269683 (UMLS CUI [3,1])
C0205396 (UMLS CUI [3,2])
C0846574 (UMLS CUI [3,3])
C0034394 (UMLS CUI [3,4])
C0220952 (UMLS CUI [3,5])
C0679229 (UMLS CUI [3,6])
C0683844 (UMLS CUI [3,7])
C0039457 (UMLS CUI [3,8])
C0021821 (UMLS CUI [3,9])
C0870294 (UMLS CUI [3,10])
C0237412 (UMLS CUI [3,11])
C1948053 (UMLS CUI [4,1])
C0024492 (UMLS CUI [4,2])
C1879301 (UMLS CUI [4,3])
C0392762 (UMLS CUI [4,4])
C2964552 (UMLS CUI [4,5])
C1842981 (UMLS CUI [4,6])
C1948053 (UMLS CUI [5,1])
C1515021 (UMLS CUI [5,2])
C0039457 (UMLS CUI [5,3])
C0021821 (UMLS CUI [5,4])
C0034394 (UMLS CUI [5,5])
C1948053 (UMLS CUI [6,1])
C0037047 (UMLS CUI [6,2])
C4553529 (UMLS CUI [6,3])
C0205403 (UMLS CUI [6,4])
C1842981 (UMLS CUI [6,5])
C2964552 (UMLS CUI [6,6])
C0451085 (UMLS CUI [6,7])
C1269683 (UMLS CUI [6,8])
C0220952 (UMLS CUI [6,9])
C1948053 (UMLS CUI [7,1])
C0037047 (UMLS CUI [7,2])
C1298908 (UMLS CUI [7,3])
C4553529 (UMLS CUI [7,4])
C0205403 (UMLS CUI [7,5])
C1842981 (UMLS CUI [7,6])
C2964552 (UMLS CUI [7,7])
C0451085 (UMLS CUI [7,8])
C1269683 (UMLS CUI [7,9])
C0220952 (UMLS CUI [7,10])
C1948053 (UMLS CUI [8,1])
C0039457 (UMLS CUI [8,2])
C0034394 (UMLS CUI [8,3])
C0038580 (UMLS CUI [8,4])
C0028043 (UMLS CUI [8,5])
C0085762 (UMLS CUI [8,6])
C0220908 (UMLS CUI [9,1])
C0024713 (UMLS CUI [9,2])
C0442809 (UMLS CUI [9,3])
C0021822 (UMLS CUI [9,4])
C1298908 (UMLS CUI [10,1])
C1512693 (UMLS CUI [10,2])
C0220908 (UMLS CUI [10,3])
C0033975 (UMLS CUI [10,4])
C0332149 (UMLS CUI [11,1])
C1512693 (UMLS CUI [11,2])
C0030705 (UMLS CUI [11,3])
C0024713 (UMLS CUI [11,4])
C0033975 (UMLS CUI [11,5])
C1698493 (UMLS CUI [11,6])
Elig.phs000658.v1.p1.2
Item
*Sub-study VU:* These samples do not overlap with those included in a prior MDD GWAS (PMID: 19065144, dbGaP: phs000020.v2.p1) but are drawn from the same parent studies (and include a small number of related individuals). Similar inclusion and exclusion criteria were used to select MDD cases from both the NESDA and NTR studies. Inclusion criteria were a lifetime diagnosis of DSM-IV MDD as determined by the Composite International Diagnostic Interview, age 18-65 years, and self-reported western European ancestry. Those not fluent in Dutch or with a primary diagnosis of schizophrenia.
boolean
C1298908 (UMLS CUI [1,1])
C1948020 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,3])
C0947630 (UMLS CUI [1,4])
C0807980 (UMLS CUI [2,1])
C0445247 (UMLS CUI [2,2])
C0030551 (UMLS CUI [2,3])
C0947630 (UMLS CUI [2,4])
C1512693 (UMLS CUI [3,1])
C0011900 (UMLS CUI [3,2])
C4071830 (UMLS CUI [3,3])
C1269683 (UMLS CUI [3,4])
C0220952 (UMLS CUI [3,5])
C0001779 (UMLS CUI [3,6])
C2700446 (UMLS CUI [3,7])
C1257905 (UMLS CUI [3,8])
C0680251 (UMLS CUI [4,1])
C1299585 (UMLS CUI [4,2])
C0564215 (UMLS CUI [4,3])
C0376241 (UMLS CUI [4,4])
C0205225 (UMLS CUI [4,5])
C0011900 (UMLS CUI [4,6])
C0036341 (UMLS CUI [4,7])
Elig.phs000658.v1.p1.3
Item
*Sub-study ED:* MDD cases were recruited through in- and out-patient services of psychiatric hospitals in Scotland and were tertiary referrals from primary care. All patients were interviewed by an experienced psychiatrist using the Schedule for Affective Disorders and Schizophrenia-Lifetime, supplemented by hospital case note review and information from informants. Final determination of MDD as the primary DSM-IV diagnosis was made by consensus of two psychiatrists. All cases had a lifetime history of recurrent MDD and IQ > 70. No phenotypic data other than diagnosis and sex are available for this cohort.
boolean
C0242800 (UMLS CUI [1,1])
C1269683 (UMLS CUI [1,2])
C0020021 (UMLS CUI [1,3])
C0036453 (UMLS CUI [1,4])
C0205372 (UMLS CUI [1,5])
C0034927 (UMLS CUI [1,6])
C0033131 (UMLS CUI [1,7])
C0021822 (UMLS CUI [2,1])
C0033872 (UMLS CUI [2,2])
C1524063 (UMLS CUI [2,3])
C0683462 (UMLS CUI [2,4])
C3842891 (UMLS CUI [2,5])
C1546485 (UMLS CUI [3,1])
C1269683 (UMLS CUI [3,2])
C0332137 (UMLS CUI [3,3])
C0220952 (UMLS CUI [3,4])
C0376298 (UMLS CUI [3,5])
C0205448 (UMLS CUI [3,6])
C0033872 (UMLS CUI [3,7])
C4071830 (UMLS CUI [4,1])
C0262926 (UMLS CUI [4,2])
C1269683 (UMLS CUI [4,3])
C1298908 (UMLS CUI [5,1])
C0031437 (UMLS CUI [5,2])
C1511726 (UMLS CUI [5,3])
C0332300 (UMLS CUI [5,4])
C0011900 (UMLS CUI [5,5])
C0079399 (UMLS CUI [5,6])
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