ID

45601

Description

Principal Investigator: Patrick F. Sullivan, University of North Carolina, Chapel Hill, NC, USA MeSH: Major Depressive Disorder https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000658 Sub-study QI: 941 cases of Major Depressive Disorder (MDD) from the Queensland Institute of Medical Research (QIMR), Australia Sub-study VU: 127 MDD cases from The Netherlands Study of Anxiety and Depression (NESDA) (http://www.nesda.nl) and The Netherlands Twin Registry (NTR) (http://www.tweelingenregister.org) based at the VU Amsterdam, The Netherlands. Sub-study ED: 373 MDD cases from the University of Edinburgh, UK.

Link

dbGaP-study=phs000658

Keywords

Versions (1)
  1. 2/14/23 2/14/23 - Chiara Middel
Copyright Holder

Patrick F. Sullivan, University of North Carolina, Chapel Hill, NC, USA

Uploaded on

February 14, 2023

DOI

To request one please log in.

License

Creative Commons BY 4.0
Model comments :

You can comment on the data model here. Via the speech bubbles at the itemgroups and items you can add comments to those specificially.

Back to model comments
Itemgroup comments for :

Item comments for :

  • Newest
  • Oldest
  • Popular
  • Newest
    • Newest
    • Oldest
    • Popular

    No comments

    In order to download data models you must be logged in. Please log in or register for free.

    dbGaP phs000658 MDD2000AFFY

    English

    Eligibility Criteria

    5 forms  
    Inclusion and exclusion criteria
    Description

    Inclusion and exclusion criteria

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C0680251
    *Sub-study QI:* Study participants were adult twins and their families recruited through the Australian Twin Registry (http://www.twins.org.au) at the Queensland Institute of Medical Research (QIMR). Only unrelated individuals were included in MDD2000AFFY. MDD cases were identified through psychiatric questionnaires, either the shortened Composite International Diagnostic Interview or, for the majority (94%), through the SSAGA-OZ interview instrument (a version of the Semi-Structured Assessment for the Genetics of Alcoholism modified for use in Australia), a comprehensive psychiatric interview designed to assess MDD and other psychiatric disorders according to DSM-IIIR and DSM-IV criteria. Structured interviews were administered by trained telephone interviewers, closely supervised by a clinical psychologist. Briefly, from 1988 to 1990, study participants were mailed an extensive health and lifestyle questionnaire, which included the shortened revised Eysenck personality questionnaire. Sum scores of 12 item responses in each personality domain resulted in quantitative scores for neuroticism. Between 1992-2000, an unselected subset of these participants were interviewed by telephone using the SSAGA-OZ. Over the period 1996-1999 sibling pairs that were either concordant or discordant for extreme neuroticism scores (one sibling in the top or bottom decile, the other sibling in the top or bottom quintile) were recruited to complete the Composite International Diagnostic Interview, which provides DSM-IV lifetime diagnoses of MDD. Finally, some study participants completed the SSAGA-OZ telephone questionnaire in 2003-2007 as part of alcohol and nicotine dependence studies. Screening items for mania were not consistent across interviews and screening items for psychosis were not included; the ability to assess accurately these less common criteria is difficult in large-scale community settings. Therefore, it is possible that a small number of individuals with a primary diagnosis of bipolar disorder or schizophrenia are included in the case group. Some participants may be the same or relatives of those in the OZ-ALC study (dbGaP phs000181.v1.p1).
    Description

    Elig.phs000658.v1.p1.1

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0242800
    UMLS CUI [1,2]
    C0041427
    UMLS CUI [1,3]
    C0030761
    UMLS CUI [1,4]
    C0015576
    UMLS CUI [1,5]
    C0034975
    UMLS CUI [2,1]
    C1512693
    UMLS CUI [2,2]
    C0030705
    UMLS CUI [2,3]
    C1546988
    UMLS CUI [3,1]
    C1269683
    UMLS CUI [3,2]
    C0205396
    UMLS CUI [3,3]
    C0846574
    UMLS CUI [3,4]
    C0034394
    UMLS CUI [3,5]
    C0220952
    UMLS CUI [3,6]
    C0679229
    UMLS CUI [3,7]
    C0683844
    UMLS CUI [3,8]
    C0039457
    UMLS CUI [3,9]
    C0021821
    UMLS CUI [3,10]
    C0870294
    UMLS CUI [3,11]
    C0237412
    UMLS CUI [4,1]
    C1948053
    UMLS CUI [4,2]
    C0024492
    UMLS CUI [4,3]
    C1879301
    UMLS CUI [4,4]
    C0392762
    UMLS CUI [4,5]
    C2964552
    UMLS CUI [4,6]
    C1842981
    UMLS CUI [5,1]
    C1948053
    UMLS CUI [5,2]
    C1515021
    UMLS CUI [5,3]
    C0039457
    UMLS CUI [5,4]
    C0021821
    UMLS CUI [5,5]
    C0034394
    UMLS CUI [6,1]
    C1948053
    UMLS CUI [6,2]
    C0037047
    UMLS CUI [6,3]
    C4553529
    UMLS CUI [6,4]
    C0205403
    UMLS CUI [6,5]
    C1842981
    UMLS CUI [6,6]
    C2964552
    UMLS CUI [6,7]
    C0451085
    UMLS CUI [6,8]
    C1269683
    UMLS CUI [6,9]
    C0220952
    UMLS CUI [7,1]
    C1948053
    UMLS CUI [7,2]
    C0037047
    UMLS CUI [7,3]
    C1298908
    UMLS CUI [7,4]
    C4553529
    UMLS CUI [7,5]
    C0205403
    UMLS CUI [7,6]
    C1842981
    UMLS CUI [7,7]
    C2964552
    UMLS CUI [7,8]
    C0451085
    UMLS CUI [7,9]
    C1269683
    UMLS CUI [7,10]
    C0220952
    UMLS CUI [8,1]
    C1948053
    UMLS CUI [8,2]
    C0039457
    UMLS CUI [8,3]
    C0034394
    UMLS CUI [8,4]
    C0038580
    UMLS CUI [8,5]
    C0028043
    UMLS CUI [8,6]
    C0085762
    UMLS CUI [9,1]
    C0220908
    UMLS CUI [9,2]
    C0024713
    UMLS CUI [9,3]
    C0442809
    UMLS CUI [9,4]
    C0021822
    UMLS CUI [10,1]
    C1298908
    UMLS CUI [10,2]
    C1512693
    UMLS CUI [10,3]
    C0220908
    UMLS CUI [10,4]
    C0033975
    UMLS CUI [11,1]
    C0332149
    UMLS CUI [11,2]
    C1512693
    UMLS CUI [11,3]
    C0030705
    UMLS CUI [11,4]
    C0024713
    UMLS CUI [11,5]
    C0033975
    UMLS CUI [11,6]
    C1698493
    *Sub-study VU:* These samples do not overlap with those included in a prior MDD GWAS (PMID: 19065144, dbGaP: phs000020.v2.p1) but are drawn from the same parent studies (and include a small number of related individuals). Similar inclusion and exclusion criteria were used to select MDD cases from both the NESDA and NTR studies. Inclusion criteria were a lifetime diagnosis of DSM-IV MDD as determined by the Composite International Diagnostic Interview, age 18-65 years, and self-reported western European ancestry. Those not fluent in Dutch or with a primary diagnosis of schizophrenia.
    Description

    Elig.phs000658.v1.p1.2

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1298908
    UMLS CUI [1,2]
    C1948020
    UMLS CUI [1,3]
    C0205156
    UMLS CUI [1,4]
    C0947630
    UMLS CUI [2,1]
    C0807980
    UMLS CUI [2,2]
    C0445247
    UMLS CUI [2,3]
    C0030551
    UMLS CUI [2,4]
    C0947630
    UMLS CUI [3,1]
    C1512693
    UMLS CUI [3,2]
    C0011900
    UMLS CUI [3,3]
    C4071830
    UMLS CUI [3,4]
    C1269683
    UMLS CUI [3,5]
    C0220952
    UMLS CUI [3,6]
    C0001779
    UMLS CUI [3,7]
    C2700446
    UMLS CUI [3,8]
    C1257905
    UMLS CUI [4,1]
    C0680251
    UMLS CUI [4,2]
    C1299585
    UMLS CUI [4,3]
    C0564215
    UMLS CUI [4,4]
    C0376241
    UMLS CUI [4,5]
    C0205225
    UMLS CUI [4,6]
    C0011900
    UMLS CUI [4,7]
    C0036341
    *Sub-study ED:* MDD cases were recruited through in- and out-patient services of psychiatric hospitals in Scotland and were tertiary referrals from primary care. All patients were interviewed by an experienced psychiatrist using the Schedule for Affective Disorders and Schizophrenia-Lifetime, supplemented by hospital case note review and information from informants. Final determination of MDD as the primary DSM-IV diagnosis was made by consensus of two psychiatrists. All cases had a lifetime history of recurrent MDD and IQ > 70. No phenotypic data other than diagnosis and sex are available for this cohort.
    Description

    Elig.phs000658.v1.p1.3

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0242800
    UMLS CUI [1,2]
    C1269683
    UMLS CUI [1,3]
    C0020021
    UMLS CUI [1,4]
    C0036453
    UMLS CUI [1,5]
    C0205372
    UMLS CUI [1,6]
    C0034927
    UMLS CUI [1,7]
    C0033131
    UMLS CUI [2,1]
    C0021822
    UMLS CUI [2,2]
    C0033872
    UMLS CUI [2,3]
    C1524063
    UMLS CUI [2,4]
    C0683462
    UMLS CUI [2,5]
    C3842891
    UMLS CUI [3,1]
    C1546485
    UMLS CUI [3,2]
    C1269683
    UMLS CUI [3,3]
    C0332137
    UMLS CUI [3,4]
    C0220952
    UMLS CUI [3,5]
    C0376298
    UMLS CUI [3,6]
    C0205448
    UMLS CUI [3,7]
    C0033872
    UMLS CUI [4,1]
    C4071830
    UMLS CUI [4,2]
    C0262926
    UMLS CUI [4,3]
    C1269683
    UMLS CUI [5,1]
    C1298908
    UMLS CUI [5,2]
    C0031437
    UMLS CUI [5,3]
    C1511726
    UMLS CUI [5,4]
    C0332300
    UMLS CUI [5,5]
    C0011900
    UMLS CUI [5,6]
    C0079399
    Back to the top of the page

    Similar models

    Eligibility Criteria

    5 forms
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    Inclusion and exclusion criteria
    C1512693 (UMLS CUI [1,1])
    C0680251 (UMLS CUI [1,2])
    Elig.phs000658.v1.p1.1
    Item
    *Sub-study QI:* Study participants were adult twins and their families recruited through the Australian Twin Registry (http://www.twins.org.au) at the Queensland Institute of Medical Research (QIMR). Only unrelated individuals were included in MDD2000AFFY. MDD cases were identified through psychiatric questionnaires, either the shortened Composite International Diagnostic Interview or, for the majority (94%), through the SSAGA-OZ interview instrument (a version of the Semi-Structured Assessment for the Genetics of Alcoholism modified for use in Australia), a comprehensive psychiatric interview designed to assess MDD and other psychiatric disorders according to DSM-IIIR and DSM-IV criteria. Structured interviews were administered by trained telephone interviewers, closely supervised by a clinical psychologist. Briefly, from 1988 to 1990, study participants were mailed an extensive health and lifestyle questionnaire, which included the shortened revised Eysenck personality questionnaire. Sum scores of 12 item responses in each personality domain resulted in quantitative scores for neuroticism. Between 1992-2000, an unselected subset of these participants were interviewed by telephone using the SSAGA-OZ. Over the period 1996-1999 sibling pairs that were either concordant or discordant for extreme neuroticism scores (one sibling in the top or bottom decile, the other sibling in the top or bottom quintile) were recruited to complete the Composite International Diagnostic Interview, which provides DSM-IV lifetime diagnoses of MDD. Finally, some study participants completed the SSAGA-OZ telephone questionnaire in 2003-2007 as part of alcohol and nicotine dependence studies. Screening items for mania were not consistent across interviews and screening items for psychosis were not included; the ability to assess accurately these less common criteria is difficult in large-scale community settings. Therefore, it is possible that a small number of individuals with a primary diagnosis of bipolar disorder or schizophrenia are included in the case group. Some participants may be the same or relatives of those in the OZ-ALC study (dbGaP phs000181.v1.p1).
    boolean
    C0242800 (UMLS CUI [1,1])
    C0041427 (UMLS CUI [1,2])
    C0030761 (UMLS CUI [1,3])
    C0015576 (UMLS CUI [1,4])
    C0034975 (UMLS CUI [1,5])
    C1512693 (UMLS CUI [2,1])
    C0030705 (UMLS CUI [2,2])
    C1546988 (UMLS CUI [2,3])
    C1269683 (UMLS CUI [3,1])
    C0205396 (UMLS CUI [3,2])
    C0846574 (UMLS CUI [3,3])
    C0034394 (UMLS CUI [3,4])
    C0220952 (UMLS CUI [3,5])
    C0679229 (UMLS CUI [3,6])
    C0683844 (UMLS CUI [3,7])
    C0039457 (UMLS CUI [3,8])
    C0021821 (UMLS CUI [3,9])
    C0870294 (UMLS CUI [3,10])
    C0237412 (UMLS CUI [3,11])
    C1948053 (UMLS CUI [4,1])
    C0024492 (UMLS CUI [4,2])
    C1879301 (UMLS CUI [4,3])
    C0392762 (UMLS CUI [4,4])
    C2964552 (UMLS CUI [4,5])
    C1842981 (UMLS CUI [4,6])
    C1948053 (UMLS CUI [5,1])
    C1515021 (UMLS CUI [5,2])
    C0039457 (UMLS CUI [5,3])
    C0021821 (UMLS CUI [5,4])
    C0034394 (UMLS CUI [5,5])
    C1948053 (UMLS CUI [6,1])
    C0037047 (UMLS CUI [6,2])
    C4553529 (UMLS CUI [6,3])
    C0205403 (UMLS CUI [6,4])
    C1842981 (UMLS CUI [6,5])
    C2964552 (UMLS CUI [6,6])
    C0451085 (UMLS CUI [6,7])
    C1269683 (UMLS CUI [6,8])
    C0220952 (UMLS CUI [6,9])
    C1948053 (UMLS CUI [7,1])
    C0037047 (UMLS CUI [7,2])
    C1298908 (UMLS CUI [7,3])
    C4553529 (UMLS CUI [7,4])
    C0205403 (UMLS CUI [7,5])
    C1842981 (UMLS CUI [7,6])
    C2964552 (UMLS CUI [7,7])
    C0451085 (UMLS CUI [7,8])
    C1269683 (UMLS CUI [7,9])
    C0220952 (UMLS CUI [7,10])
    C1948053 (UMLS CUI [8,1])
    C0039457 (UMLS CUI [8,2])
    C0034394 (UMLS CUI [8,3])
    C0038580 (UMLS CUI [8,4])
    C0028043 (UMLS CUI [8,5])
    C0085762 (UMLS CUI [8,6])
    C0220908 (UMLS CUI [9,1])
    C0024713 (UMLS CUI [9,2])
    C0442809 (UMLS CUI [9,3])
    C0021822 (UMLS CUI [9,4])
    C1298908 (UMLS CUI [10,1])
    C1512693 (UMLS CUI [10,2])
    C0220908 (UMLS CUI [10,3])
    C0033975 (UMLS CUI [10,4])
    C0332149 (UMLS CUI [11,1])
    C1512693 (UMLS CUI [11,2])
    C0030705 (UMLS CUI [11,3])
    C0024713 (UMLS CUI [11,4])
    C0033975 (UMLS CUI [11,5])
    C1698493 (UMLS CUI [11,6])
    Elig.phs000658.v1.p1.2
    Item
    *Sub-study VU:* These samples do not overlap with those included in a prior MDD GWAS (PMID: 19065144, dbGaP: phs000020.v2.p1) but are drawn from the same parent studies (and include a small number of related individuals). Similar inclusion and exclusion criteria were used to select MDD cases from both the NESDA and NTR studies. Inclusion criteria were a lifetime diagnosis of DSM-IV MDD as determined by the Composite International Diagnostic Interview, age 18-65 years, and self-reported western European ancestry. Those not fluent in Dutch or with a primary diagnosis of schizophrenia.
    boolean
    C1298908 (UMLS CUI [1,1])
    C1948020 (UMLS CUI [1,2])
    C0205156 (UMLS CUI [1,3])
    C0947630 (UMLS CUI [1,4])
    C0807980 (UMLS CUI [2,1])
    C0445247 (UMLS CUI [2,2])
    C0030551 (UMLS CUI [2,3])
    C0947630 (UMLS CUI [2,4])
    C1512693 (UMLS CUI [3,1])
    C0011900 (UMLS CUI [3,2])
    C4071830 (UMLS CUI [3,3])
    C1269683 (UMLS CUI [3,4])
    C0220952 (UMLS CUI [3,5])
    C0001779 (UMLS CUI [3,6])
    C2700446 (UMLS CUI [3,7])
    C1257905 (UMLS CUI [3,8])
    C0680251 (UMLS CUI [4,1])
    C1299585 (UMLS CUI [4,2])
    C0564215 (UMLS CUI [4,3])
    C0376241 (UMLS CUI [4,4])
    C0205225 (UMLS CUI [4,5])
    C0011900 (UMLS CUI [4,6])
    C0036341 (UMLS CUI [4,7])
    Elig.phs000658.v1.p1.3
    Item
    *Sub-study ED:* MDD cases were recruited through in- and out-patient services of psychiatric hospitals in Scotland and were tertiary referrals from primary care. All patients were interviewed by an experienced psychiatrist using the Schedule for Affective Disorders and Schizophrenia-Lifetime, supplemented by hospital case note review and information from informants. Final determination of MDD as the primary DSM-IV diagnosis was made by consensus of two psychiatrists. All cases had a lifetime history of recurrent MDD and IQ > 70. No phenotypic data other than diagnosis and sex are available for this cohort.
    boolean
    C0242800 (UMLS CUI [1,1])
    C1269683 (UMLS CUI [1,2])
    C0020021 (UMLS CUI [1,3])
    C0036453 (UMLS CUI [1,4])
    C0205372 (UMLS CUI [1,5])
    C0034927 (UMLS CUI [1,6])
    C0033131 (UMLS CUI [1,7])
    C0021822 (UMLS CUI [2,1])
    C0033872 (UMLS CUI [2,2])
    C1524063 (UMLS CUI [2,3])
    C0683462 (UMLS CUI [2,4])
    C3842891 (UMLS CUI [2,5])
    C1546485 (UMLS CUI [3,1])
    C1269683 (UMLS CUI [3,2])
    C0332137 (UMLS CUI [3,3])
    C0220952 (UMLS CUI [3,4])
    C0376298 (UMLS CUI [3,5])
    C0205448 (UMLS CUI [3,6])
    C0033872 (UMLS CUI [3,7])
    C4071830 (UMLS CUI [4,1])
    C0262926 (UMLS CUI [4,2])
    C1269683 (UMLS CUI [4,3])
    C1298908 (UMLS CUI [5,1])
    C0031437 (UMLS CUI [5,2])
    C1511726 (UMLS CUI [5,3])
    C0332300 (UMLS CUI [5,4])
    C0011900 (UMLS CUI [5,5])
    C0079399 (UMLS CUI [5,6])
    Back to the top of the page 

    Help

    Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

    Watch Tutorial