Información:
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ID
45593
Descripción
Principal Investigator: Lisa Boardman, MD, Mayo Clinic, Rochester, MN, USA MeSH: Colorectal Neoplasms,Adenoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001384 In the US, CRC incidence has declined with uptake in colonoscopy for early detection and removal of polyps, the precursor lesion, can stop a cancer from developing but in spite of this, CRC remains the second leading cause of cancer death in the United States. One third of people who undergo screening colonoscopy will have adenomatous polyps, but less than 5% of the time are these polyps presumed to go on to develop into cancer. Why does one polyp develop into cancer while another one that looks very similar does not. In this proposal we will identify what molecular genetic changes in the genome, in the mRNA expression and genetic methylation patterns will distinguish a polyp that has already transformed into cancer from one that has not.
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Versiones (1)
- 6/2/23 6/2/23 - Simon Heim
Titular de derechos de autor
Lisa Boardman, MD, Mayo Clinic, Rochester, MN, USA
Subido en
6 de febrero de 2023
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs001384 Time Lapse to Cancer-Defining the Transition from Polyp to Cancer
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs, consent group information, subject source, and affection status for polyp to cancer.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and sample source.
- This subject phenotype table includes subjects' age, sex, and race.
- This sample attributes table includes body site where sample was collected, analyte type, histological type, tumor status, tumor stage, and sequencing center.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs, consent group information, subject source, and affection status for polyp to cancer.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and sample source.
- This subject phenotype table includes subjects' age, sex, and race.
- This sample attributes table includes body site where sample was collected, analyte type, histological type, tumor status, tumor stage, and sequencing center.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
*Inclusion Criteria:*
Item
*Inclusion Criteria:*
boolean
C1512693 (UMLS CUI [1,1])
Patients scheduled for GI tract cancer; polyp or inflammatory bowel disease surgery or endoscopy for clinical reasons
Item
Patients scheduled for GI tract cancer; polyp or inflammatory bowel disease surgery or endoscopy for clinical reasons
boolean
C0205539 (UMLS CUI [1,1])
C0685938 (UMLS CUI [1,2])
C0032584 (UMLS CUI [1,3])
C0021390 (UMLS CUI [1,4])
C0543467 (UMLS CUI [1,5])
C0014245 (UMLS CUI [1,6])
C0205210 (UMLS CUI [1,7])
C0685938 (UMLS CUI [1,2])
C0032584 (UMLS CUI [1,3])
C0021390 (UMLS CUI [1,4])
C0543467 (UMLS CUI [1,5])
C0014245 (UMLS CUI [1,6])
C0205210 (UMLS CUI [1,7])
Patients with known, suspected or prior history of GI tract cancer or polyps, or family history of gastric cancer, small bowel cancer, GIST and/or colorectal cancer and/or inflammatory bowel disease and who are undergoing endoscopy as part of their medical evaluation.
Item
Patients with known, suspected or prior history of GI tract cancer or polyps, or family history of gastric cancer, small bowel cancer, GIST and/or colorectal cancer and/or inflammatory bowel disease and who are undergoing endoscopy as part of their medical evaluation.
boolean
C0205309 (UMLS CUI [1,1])
C0332147 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C0685938 (UMLS CUI [1,4])
C0032584 (UMLS CUI [1,5])
C0241889 (UMLS CUI [1,6])
C0024623 (UMLS CUI [1,7])
C0153425 (UMLS CUI [1,8])
C0238198 (UMLS CUI [1,9])
C0009402 (UMLS CUI [1,10])
C0021390 (UMLS CUI [1,11])
C0014245 (UMLS CUI [1,12])
C0332147 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C0685938 (UMLS CUI [1,4])
C0032584 (UMLS CUI [1,5])
C0241889 (UMLS CUI [1,6])
C0024623 (UMLS CUI [1,7])
C0153425 (UMLS CUI [1,8])
C0238198 (UMLS CUI [1,9])
C0009402 (UMLS CUI [1,10])
C0021390 (UMLS CUI [1,11])
C0014245 (UMLS CUI [1,12])
Patients with indications for endoscopy other than GI tract cancer, polyps and who are scheduled for endoscopy as part of their medical evaluation.
Item
Patients with indications for endoscopy other than GI tract cancer, polyps and who are scheduled for endoscopy as part of their medical evaluation.
boolean
C0392360 (UMLS CUI [1,1])
C0014245 (UMLS CUI [1,2])
C4723751 (UMLS CUI [1,3])
C0685938 (UMLS CUI [1,4])
C0032584 (UMLS CUI [1,5])
C0205539 (UMLS CUI [1,6])
C0014245 (UMLS CUI [1,2])
C4723751 (UMLS CUI [1,3])
C0685938 (UMLS CUI [1,4])
C0032584 (UMLS CUI [1,5])
C0205539 (UMLS CUI [1,6])
Age ≥ 18
Item
Age ≥ 18
boolean
C0001779 (UMLS CUI [1,1])
Patients found to have a blood culture positive for Strep Bovis (infantarius, coli, gallolyticus or pasteurianus
Item
Patients found to have a blood culture positive for Strep Bovis (infantarius, coli, gallolyticus or pasteurianus
boolean
C0740299 (UMLS CUI [1,1])
C0749059 (UMLS CUI [1,2])
C0749059 (UMLS CUI [1,2])
*Exclusion Criteria:*
Item
*Exclusion Criteria:*
boolean
C0680251 (UMLS CUI [1,1])
Individuals who do not comprehend English (i.e., participants must be able to read and sign a consent form without the assistance of an interpreter.)
Item
Individuals who do not comprehend English (i.e., participants must be able to read and sign a consent form without the assistance of an interpreter.)
boolean
C4274549 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
C0586740 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])
C0376245 (UMLS CUI [1,2])
C0586740 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])
Age < 18
Item
Age < 18
boolean
C0001779 (UMLS CUI [1,1])
Individuals who are unable to sign consent (e.g., mentally challenged, those declared legally incompetent).
Item
Individuals who are unable to sign consent (e.g., mentally challenged, those declared legally incompetent).
boolean
C1299582 (UMLS CUI [1,1])
C0021430 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,2])
Individuals regarded as belonging to a vulnerable population (e.g., prisoners).
Item
Individuals regarded as belonging to a vulnerable population (e.g., prisoners).
boolean
C0949366 (UMLS CUI [1,1])
C0033167 (UMLS CUI [1,2])
C0033167 (UMLS CUI [1,2])