ID

45591

Beskrivning

Principal Investigator: James T. Elder, MD, PhD, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA MeSH: Psoriasis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001306 The genotypes obtained from the Affymetrix Biobank Plus array constituted one of eight Caucasian datasets used in a large genome-wide meta-analysis of the association of psoriasis cases versus unaffected controls. With a combined effective sample size of 39,000 individuals, this study identified 16 new psoriasis loci achieving genome-wide significance, increasing the total number of identified psoriasis loci for European-ancestry populations to 63.

Länk

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001306

Nyckelord

  1. 01/02/2023 01/02/2023 - Dr. med. Lucy Kessler
Rättsinnehavare

James T. Elder, MD, PhD, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA

Uppladdad den

1 février 2023

DOI

För en begäran logga in.

Licens

Creative Commons BY 4.0

Modellkommentarer :

Här kan du kommentera modellen. Med hjälp av pratbubblor i Item-grupperna och Item kan du lägga in specifika kommentarer.

Itemgroup-kommentar för :

Item-kommentar för :

Du måste vara inloggad för att kunna ladda ner formulär. Var vänlig logga in eller registrera dig utan kostnad.

dbGaP phs001306 Large Scale Meta-analysis Characterizes Genetic Architecture for Common Psoriasis-associated Variants

Eligibility Criteria

Inclusion and exclusion criteria
Beskrivning

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
Psoriasis cases were diagnosed by a dermatologist. Controls were at least 18 years of age and unaffected with psoriasis. All study participants were of self-reported European Caucasian ancestry. Cases and control individuals were recruited at five different locations - Michigan and Utah in the United States, Toronto and Newfoundland in Canada, and in Sweden.
Beskrivning

Elig.phs001306.v1.p1.1

Datatyp

boolean

Alias
UMLS CUI [1,1]
C3846158
Samples with > 2% missing genotypes on the Affymetrix Biobank Plus array, an absolute value of the F inbreeding coefficient > 0.03, significant non-Caucasian admixture by principal components analysis, or that were duplicates of or highly related to (Plink Pi_hat > 0.25) individuals within this dataset or with the other seven datasets of Tsoi et al. (2017) were removed before analysis. After quality control, 7,891 individuals from the Affymetrix Biobank Plus dataset (3,863 cases and 4,028 controls) were used for the meta-analysis of Tsoi et al (2017). However, the dataset deposited here (5,942 cases and 5,732 controls) represents application of all quality control filters except the removal of samples that were duplicates or relative pairs with individuals of the other seven datasets.
Beskrivning

Elig.phs001306.v1.p1.2

Datatyp

boolean

Alias
UMLS CUI [1,1]
C3846158

Similar models

Eligibility Criteria

Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001306.v1.p1.1
Item
Psoriasis cases were diagnosed by a dermatologist. Controls were at least 18 years of age and unaffected with psoriasis. All study participants were of self-reported European Caucasian ancestry. Cases and control individuals were recruited at five different locations - Michigan and Utah in the United States, Toronto and Newfoundland in Canada, and in Sweden.
boolean
C3846158 (UMLS CUI [1,1])
Elig.phs001306.v1.p1.2
Item
Samples with > 2% missing genotypes on the Affymetrix Biobank Plus array, an absolute value of the F inbreeding coefficient > 0.03, significant non-Caucasian admixture by principal components analysis, or that were duplicates of or highly related to (Plink Pi_hat > 0.25) individuals within this dataset or with the other seven datasets of Tsoi et al. (2017) were removed before analysis. After quality control, 7,891 individuals from the Affymetrix Biobank Plus dataset (3,863 cases and 4,028 controls) were used for the meta-analysis of Tsoi et al (2017). However, the dataset deposited here (5,942 cases and 5,732 controls) represents application of all quality control filters except the removal of samples that were duplicates or relative pairs with individuals of the other seven datasets.
boolean
C3846158 (UMLS CUI [1,1])

Använd detta formulär för feedback, frågor och förslag på förbättringar.

Fält markerade med * är obligatoriska.

Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

Watch Tutorial