ID

45575

Beschrijving

Principal Investigator: Mark Silverberg, MD., PhD, Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, CANADA MeSH: Inflammatory Bowel Diseases,Crohn Disease,Colitis, Ulcerative,Pouchitis,Adenomatous Polyposis Coli https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000659 This study involved evaluation of the tissue associated microbiome of the ileal pouch following surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted and sequenced using 454 pyrosequencing. Total bacterial community structure and abundance were evaluated to determine which changes were characteristic of inflammatory phenotypes including pouchitis (inflammation of the ileal pouch) and a Crohn's disease-like phenotype.

Link

dbGaP study = phs000659

Trefwoorden

Versies (1)
  1. 24-01-23 24-01-23 - Simon Heim
Houder van rechten

Mark Silverberg, MD., PhD, Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, CANADA

Geüploaded op

24 januari 2023

DOI

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Licentie

Creative Commons BY 4.0
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dbGaP phs000659 Mount Sinai Hospital (MSH, Toronto, CANADA) pelvic pouch microbiome study

Engels

Eligibility Criteria

5 Formulieren  
Inclusion and exclusion criteria
Beschrijving

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Inclusion Criteria*
Beschrijving

*Inclusion Criteria*

Datatype

boolean

Alias
UMLS CUI [1,1]
C1512693
Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment
Beschrijving

Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment

Datatype

boolean

Alias
UMLS CUI [1,1]
C4505465
UMLS CUI [1,2]
C0009324
UMLS CUI [1,3]
C0032580
UMLS CUI [1,4]
C0192775
UMLS CUI [1,5]
C0332152
UMLS CUI [1,6]
C1516879
Sufficient clinical information is available to classify patients into post-surgical outcome groups
Beschrijving

Sufficient clinical information is available to classify patients into post-surgical outcome groups

Datatype

boolean

Alias
UMLS CUI [1,1]
C0205410
UMLS CUI [1,2]
C2708733
UMLS CUI [1,3]
C0470187
UMLS CUI [1,4]
C0008902
UMLS CUI [1,5]
C0085415
UMLS CUI [1,6]
C0543467
UMLS CUI [1,7]
C1257890
Patients willing to undergo study pouchoscopy with biopsy
Beschrijving

Patients willing to undergo study pouchoscopy with biopsy

Datatype

boolean

Alias
UMLS CUI [1,1]
C0030705
UMLS CUI [1,2]
C2586066
UMLS CUI [1,3]
C2609084
UMLS CUI [1,4]
C0005558
*Exclusion Criteria*
Beschrijving

*Exclusion Criteria*

Datatype

boolean

Alias
UMLS CUI [1,1]
C0680251
Pre-surgical diagnosis of Crohn's disease
Beschrijving

Pre-surgical diagnosis of Crohn's disease

Datatype

boolean

Alias
UMLS CUI [1,1]
C0011900
UMLS CUI [1,2]
C0445204
UMLS CUI [1,3]
C0010346
< 18 years old
Beschrijving

< 18 years old

Datatype

boolean

Alias
UMLS CUI [1,1]
C0001779
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Similar models

Eligibility Criteria

5 Formulieren
Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
*Inclusion Criteria*
Item
*Inclusion Criteria*
boolean
C1512693 (UMLS CUI [1,1])
Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment
Item
Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment
boolean
C4505465 (UMLS CUI [1,1])
C0009324 (UMLS CUI [1,2])
C0032580 (UMLS CUI [1,3])
C0192775 (UMLS CUI [1,4])
C0332152 (UMLS CUI [1,5])
C1516879 (UMLS CUI [1,6])
Sufficient clinical information is available to classify patients into post-surgical outcome groups
Item
Sufficient clinical information is available to classify patients into post-surgical outcome groups
boolean
C0205410 (UMLS CUI [1,1])
C2708733 (UMLS CUI [1,2])
C0470187 (UMLS CUI [1,3])
C0008902 (UMLS CUI [1,4])
C0085415 (UMLS CUI [1,5])
C0543467 (UMLS CUI [1,6])
C1257890 (UMLS CUI [1,7])
Patients willing to undergo study pouchoscopy with biopsy
Item
Patients willing to undergo study pouchoscopy with biopsy
boolean
C0030705 (UMLS CUI [1,1])
C2586066 (UMLS CUI [1,2])
C2609084 (UMLS CUI [1,3])
C0005558 (UMLS CUI [1,4])
*Exclusion Criteria*
Item
*Exclusion Criteria*
boolean
C0680251 (UMLS CUI [1,1])
Pre-surgical diagnosis of Crohn's disease
Item
Pre-surgical diagnosis of Crohn's disease
boolean
C0011900 (UMLS CUI [1,1])
C0445204 (UMLS CUI [1,2])
C0010346 (UMLS CUI [1,3])
< 18 years old
Item
< 18 years old
boolean
C0001779 (UMLS CUI [1,1])
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