ID

45575

Descrizione

Principal Investigator: Mark Silverberg, MD., PhD, Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, CANADA MeSH: Inflammatory Bowel Diseases,Crohn Disease,Colitis, Ulcerative,Pouchitis,Adenomatous Polyposis Coli https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000659 This study involved evaluation of the tissue associated microbiome of the ileal pouch following surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted and sequenced using 454 pyrosequencing. Total bacterial community structure and abundance were evaluated to determine which changes were characteristic of inflammatory phenotypes including pouchitis (inflammation of the ileal pouch) and a Crohn's disease-like phenotype.

collegamento

dbGaP study = phs000659

Keywords

versioni (1)
  1. 24/01/23 24/01/23 - Simon Heim
Titolare del copyright

Mark Silverberg, MD., PhD, Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, CANADA

Caricato su

24 gennaio 2023

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
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dbGaP phs000659 Mount Sinai Hospital (MSH, Toronto, CANADA) pelvic pouch microbiome study

Inglese

Eligibility Criteria

5 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Inclusion Criteria*
Descrizione

*Inclusion Criteria*

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1512693
Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment
Descrizione

Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C4505465
UMLS CUI [1,2]
C0009324
UMLS CUI [1,3]
C0032580
UMLS CUI [1,4]
C0192775
UMLS CUI [1,5]
C0332152
UMLS CUI [1,6]
C1516879
Sufficient clinical information is available to classify patients into post-surgical outcome groups
Descrizione

Sufficient clinical information is available to classify patients into post-surgical outcome groups

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0205410
UMLS CUI [1,2]
C2708733
UMLS CUI [1,3]
C0470187
UMLS CUI [1,4]
C0008902
UMLS CUI [1,5]
C0085415
UMLS CUI [1,6]
C0543467
UMLS CUI [1,7]
C1257890
Patients willing to undergo study pouchoscopy with biopsy
Descrizione

Patients willing to undergo study pouchoscopy with biopsy

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0030705
UMLS CUI [1,2]
C2586066
UMLS CUI [1,3]
C2609084
UMLS CUI [1,4]
C0005558
*Exclusion Criteria*
Descrizione

*Exclusion Criteria*

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
Pre-surgical diagnosis of Crohn's disease
Descrizione

Pre-surgical diagnosis of Crohn's disease

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0011900
UMLS CUI [1,2]
C0445204
UMLS CUI [1,3]
C0010346
< 18 years old
Descrizione

< 18 years old

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0001779
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Similar models

Eligibility Criteria

5 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
*Inclusion Criteria*
Item
*Inclusion Criteria*
boolean
C1512693 (UMLS CUI [1,1])
Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment
Item
Patients having undergone ileal pouch-anal anastomosis for ulcerative colitis (UC) or familial adenomatous polyposis (FAP) with ileostomy closure at least one year prior to study enrollment
boolean
C4505465 (UMLS CUI [1,1])
C0009324 (UMLS CUI [1,2])
C0032580 (UMLS CUI [1,3])
C0192775 (UMLS CUI [1,4])
C0332152 (UMLS CUI [1,5])
C1516879 (UMLS CUI [1,6])
Sufficient clinical information is available to classify patients into post-surgical outcome groups
Item
Sufficient clinical information is available to classify patients into post-surgical outcome groups
boolean
C0205410 (UMLS CUI [1,1])
C2708733 (UMLS CUI [1,2])
C0470187 (UMLS CUI [1,3])
C0008902 (UMLS CUI [1,4])
C0085415 (UMLS CUI [1,5])
C0543467 (UMLS CUI [1,6])
C1257890 (UMLS CUI [1,7])
Patients willing to undergo study pouchoscopy with biopsy
Item
Patients willing to undergo study pouchoscopy with biopsy
boolean
C0030705 (UMLS CUI [1,1])
C2586066 (UMLS CUI [1,2])
C2609084 (UMLS CUI [1,3])
C0005558 (UMLS CUI [1,4])
*Exclusion Criteria*
Item
*Exclusion Criteria*
boolean
C0680251 (UMLS CUI [1,1])
Pre-surgical diagnosis of Crohn's disease
Item
Pre-surgical diagnosis of Crohn's disease
boolean
C0011900 (UMLS CUI [1,1])
C0445204 (UMLS CUI [1,2])
C0010346 (UMLS CUI [1,3])
< 18 years old
Item
< 18 years old
boolean
C0001779 (UMLS CUI [1,1])
Ritorna all'inizio della pagina 

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