ID
45573
Beschreibung
Principal Investigator: Rameen Beroukhim, MD, PhD, Dana-Farber Cancer Institute, Boston, MA 02215, USA MeSH: Meningioma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000552 Meningiomas are the most common primary brain tumor in the US. Although the tumor suppressor gene NF2 is disrupted in approximately half of meningiomas, the complete spectrum of genetic changes in meningiomas remains poorly understood, particularly in the large subset of tumors without NF2 alterations. Therefore we performed whole-genome sequencing from 11 Grade I meningioma tumor-normal pairs and whole-exome sequencing from an additional 6 tumor-normal pairs to identify somatic mutations, insertions-deletions, copy-number alterations and rearrangements. We validated our results by performing focused sequencing across 48 additional meningiomas.
Link
Stichworte
Versionen (1)
- 24.01.23 24.01.23 - Dr. Christian Niklas
Rechteinhaber
Rameen Beroukhim, MD, PhD, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Hochgeladen am
24. Januar 2023
DOI
Für eine Beantragung loggen Sie sich ein.
Lizenz
Creative Commons BY 4.0
Modell Kommentare :
Hier können Sie das Modell kommentieren. Über die Sprechblasen an den Itemgruppen und Items können Sie diese spezifisch kommentieren.
Itemgroup Kommentare für :
Item Kommentare für :
Um Formulare herunterzuladen müssen Sie angemeldet sein. Bitte loggen Sie sich ein oder registrieren Sie sich kostenlos.
dbGaP phs000552 Genomic Characterization of Meningiomas
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
- Sample ID, subject ID, and sample use variables obtained from participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
- Subject ID, age, and sex of participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
- Sample ID, body site where sample was collected, analyte type of samples, tumor status, histological type of samples, and whether the sample was obtained from recurrent tumor associated with participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
Ähnliche Modelle
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
- Sample ID, subject ID, and sample use variables obtained from participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
- Subject ID, age, and sex of participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
- Sample ID, body site where sample was collected, analyte type of samples, tumor status, histological type of samples, and whether the sample was obtained from recurrent tumor associated with participants with meningioma and involved in the "Genomic Characterization of Meningiomas" project.
C0680251 (UMLS CUI [1,2])
C0428093 (UMLS CUI [1,2])