ID

45540

Description

Principal Investigator: Anna Szekely, PhD, Institute of Psychology, Eötvös Loránd University University, Budapest, Hungary MeSH: Anxiety,Depression https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000713 GDNF gene variants were studied as possible risk factors of depression or anxiety on a young sample. The association study involved eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history. Results provided significant effects of two single nucleotide polymorphisms on anxiety scores following the Bonferroni correction for multiple testing (p=0.00070 and p=0.00138 for rs3812047 and rs3096140, respectively). Haplotype analysis confirmed the role of these SNPs (p=0.00029). A significant sex-gene interaction was also observed since the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males. This is the first demonstration of a significant association between the GDNF gene and mood characteristics demonstrated by the association of two SNPs of the GDNF gene (rs3812047 and rs3096140) and individual variability of anxiety using self-report data from a non-clinical sample. *Reprinted from Kotyuk et. al., 2013* (Kotyuk, E., Keszler, G., Nemeth, N., Ronai, Z., Sasvari-Szekely, M., and Szekely, A. (2013). Glial Cell Line-Derived Neurotrophic Factor (GDNF) as a Novel Candidate Gene of Anxiety. PLoS One,8, (12) PMID: 24324616), *with permission from Publisher* *(All content of articles published in PLOS journals is open access. You can read about our open access license here: http://www.plos.org/about/open-access/. To summarize, this license allows you to download, reuse, reprint, modify, distribute, and/or copy articles or images in PLOS journals, so long as the original creators are credited (e.g., including the article's citation and/or the image credit); Laura Perry; Staff EO;PLOS ONE)*

Link

dbGaP study = phs000713

Keywords

Versions (1)
  1. 1/3/23 1/3/23 - Simon Heim
Copyright Holder

Anna Szekely, PhD, Institute of Psychology, Eötvös Loránd University University, Budapest, Hungary

Uploaded on

January 3, 2023

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000713 GDNF and Anxiety

English

Eligibility Criteria

5 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
Non-related Caucasian (Hungarian) subjects participated on a voluntary basis from several educational facilities. They were recruited at the Institute of Psychology, Eötvös Loránd University. The study protocol was designed in accordance with guidelines of the Declaration of Helsinki, and was approved by the Scientific and Research Ethics Committee of the Medical Research Council (ETT TUKEB). The participants signed a written informed consent. Selection criteria included no past or present psychiatric history (based on self-report) and age between 18-35 years.
Description

Non-related Caucasian (Hungarian) subjects participated on a voluntary basis from several educational facilities. They were recruited at the Institute of Psychology, Eötvös Loránd University. The study protocol was designed in accordance with guidelines of the Declaration of Helsinki, and was approved by the Scientific and Research Ethics Committee of the Medical Research Council (ETT TUKEB). The participants signed a written informed consent. Selection criteria included no past or present psychiatric history (based on self-report) and age between 18-35 years.

Data type

boolean

Alias
UMLS CUI [1,1]
C0007457
UMLS CUI [1,2]
C0337807
UMLS CUI [1,3]
C0680274
UMLS CUI [1,4]
C0681325
UMLS CUI [1,5]
C0033909
UMLS CUI [1,6]
C0814875
UMLS CUI [1,7]
C1272753
UMLS CUI [1,8]
C0018898
UMLS CUI [1,9]
C0086911
UMLS CUI [1,10]
C5239206
UMLS CUI [1,11]
C0021430
UMLS CUI [1,12]
C0001779
UMLS CUI [1,13]
C1298908
UMLS CUI [1,14]
C0748059
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Similar models

Eligibility Criteria

5 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Non-related Caucasian (Hungarian) subjects participated on a voluntary basis from several educational facilities. They were recruited at the Institute of Psychology, Eötvös Loránd University. The study protocol was designed in accordance with guidelines of the Declaration of Helsinki, and was approved by the Scientific and Research Ethics Committee of the Medical Research Council (ETT TUKEB). The participants signed a written informed consent. Selection criteria included no past or present psychiatric history (based on self-report) and age between 18-35 years.
Item
Non-related Caucasian (Hungarian) subjects participated on a voluntary basis from several educational facilities. They were recruited at the Institute of Psychology, Eötvös Loránd University. The study protocol was designed in accordance with guidelines of the Declaration of Helsinki, and was approved by the Scientific and Research Ethics Committee of the Medical Research Council (ETT TUKEB). The participants signed a written informed consent. Selection criteria included no past or present psychiatric history (based on self-report) and age between 18-35 years.
boolean
C0007457 (UMLS CUI [1,1])
C0337807 (UMLS CUI [1,2])
C0680274 (UMLS CUI [1,3])
C0681325 (UMLS CUI [1,4])
C0033909 (UMLS CUI [1,5])
C0814875 (UMLS CUI [1,6])
C1272753 (UMLS CUI [1,7])
C0018898 (UMLS CUI [1,8])
C0086911 (UMLS CUI [1,9])
C5239206 (UMLS CUI [1,10])
C0021430 (UMLS CUI [1,11])
C0001779 (UMLS CUI [1,12])
C1298908 (UMLS CUI [1,13])
C0748059 (UMLS CUI [1,14])
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