ID

45540

Description

Principal Investigator: Anna Szekely, PhD, Institute of Psychology, Eötvös Loránd University University, Budapest, Hungary MeSH: Anxiety,Depression https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000713 GDNF gene variants were studied as possible risk factors of depression or anxiety on a young sample. The association study involved eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history. Results provided significant effects of two single nucleotide polymorphisms on anxiety scores following the Bonferroni correction for multiple testing (p=0.00070 and p=0.00138 for rs3812047 and rs3096140, respectively). Haplotype analysis confirmed the role of these SNPs (p=0.00029). A significant sex-gene interaction was also observed since the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males. This is the first demonstration of a significant association between the GDNF gene and mood characteristics demonstrated by the association of two SNPs of the GDNF gene (rs3812047 and rs3096140) and individual variability of anxiety using self-report data from a non-clinical sample. *Reprinted from Kotyuk et. al., 2013* (Kotyuk, E., Keszler, G., Nemeth, N., Ronai, Z., Sasvari-Szekely, M., and Szekely, A. (2013). Glial Cell Line-Derived Neurotrophic Factor (GDNF) as a Novel Candidate Gene of Anxiety. PLoS One,8, (12) PMID: 24324616), *with permission from Publisher* *(All content of articles published in PLOS journals is open access. You can read about our open access license here: http://www.plos.org/about/open-access/. To summarize, this license allows you to download, reuse, reprint, modify, distribute, and/or copy articles or images in PLOS journals, so long as the original creators are credited (e.g., including the article's citation and/or the image credit); Laura Perry; Staff EO;PLOS ONE)*

Link

dbGaP study = phs000713

Keywords

Versions (1)
  1. 1/3/23 1/3/23 - Simon Heim
Copyright Holder

Anna Szekely, PhD, Institute of Psychology, Eötvös Loránd University University, Budapest, Hungary

Uploaded on

January 3, 2023

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000713 GDNF and Anxiety

English

The dataset provides results of questions from the "Hospital Anxiety and Depression Scale", rs-marker information obtained for the chosen SNP locations (n=8), and basic socio-demographic data.

5 forms  
pht004273
Description

pht004273

Alias
UMLS CUI [1,1]
C3846158
De-identified Subject ID
Description

Subject_ID

Data type

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
Gender of participant
Description

sex

Data type

text

Alias
UMLS CUI [1,1]
C0079399
Subject age
Description

age

Data type

text

Measurement units
  • Years
Alias
UMLS CUI [1,1]
C0001779
Years
HADS (Hospital Anxiety and Depression Scale) anxiety subscale SUM
Description

HADSaOssz

Data type

float

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C5188377
UMLS CUI [1,3]
C1515051
HADS (Hospital Anxiety and Depression Scale) depression subscale SUM
Description

HADSdOssz

Data type

float

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C5188910
UMLS CUI [1,3]
C1515051
HADS (Hospital Anxiety and Depression Scale) anxiety subscale MEAN
Description

HADSaAtl

Data type

float

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C5188377
UMLS CUI [1,3]
C0444504
HADS (Hospital Anxiety and Depression Scale) depression subscale MEAN
Description

HADSdAtl

Data type

float

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C5188910
UMLS CUI [1,3]
C0444504
Number of answered items of the HADS (Hospital Anxiety and Depression Scale) anxiety subscale
Description

HADSaN

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C1822117
UMLS CUI [1,3]
C5188377
Number of answered items of the HADS (Hospital Anxiety and Depression Scale) depression subscale
Description

HADSdN

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C1822117
UMLS CUI [1,3]
C5188910
HADS (Hospital Anxiety and Depression Scale) scale item01 - already reversed
Description

HADS01aF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item02 - already reversed
Description

HADS03aF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item03 - already reversed
Description

HADS05aF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item04
Description

HADS07a

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item05
Description

HADS09a

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item06 - already reversed
Description

HADS11aF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item07 - already reversed
Description

HADS13aF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item08
Description

HADS02d

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item09
Description

HADS04d

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item10 - already reversed
Description

HADS06dF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item11 - already reversed
Description

HADS08dF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item12 - already reversed
Description

HADS10dF

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item13
Description

HADS12d

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
HADS (Hospital Anxiety and Depression Scale) scale item14
Description

HADS14d

Data type

text

Alias
UMLS CUI [1,1]
C3539657
UMLS CUI [1,2]
C0349674
2668 GDNF gene rs11111 polymorphism genotype information
Description

GDNF_rs11111

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
2668 GDNF gene rs1549250 polymorphism genotype information
Description

GDNF_rs1549250

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
2668 GDNF gene rs1981844 polymorphism genotype information
Description

GDNF_rs1981844

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
2668 GDNF gene rs2910702 polymorphism genotype information
Description

GDNF_rs2910702

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
2668 GDNF gene rs2973041 polymorphism genotype information
Description

GDNF_rs2973041

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
2668 GDNF gene rs2973050 polymorphism genotype information
Description

GDNF_rs2973050

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
2668 GDNF gene rs3096140 polymorphism genotype information
Description

GDNF_rs3096140

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
2668 GDNF gene rs3812047 polymorphism genotype information
Description

GDNF_rs3812047

Data type

string

Alias
UMLS CUI [1,1]
C1333669
UMLS CUI [1,2]
C0032529
UMLS CUI [1,3]
C1533716
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Similar models

The dataset provides results of questions from the "Hospital Anxiety and Depression Scale", rs-marker information obtained for the chosen SNP locations (n=8), and basic socio-demographic data.

5 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
pht004273
C3846158 (UMLS CUI [1,1])
Subject_ID
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
Item
Gender of participant
text
C0079399 (UMLS CUI [1,1])
sex
Code List
Gender of participant
CL Item
Male (1)
C0086582 (UMLS CUI [1,1])
CL Item
Female (2)
C0086287 (UMLS CUI [1,1])
age
Item
Subject age
text
C0001779 (UMLS CUI [1,1])
HADSaOssz
Item
HADS (Hospital Anxiety and Depression Scale) anxiety subscale SUM
float
C3539657 (UMLS CUI [1,1])
C5188377 (UMLS CUI [1,2])
C1515051 (UMLS CUI [1,3])
HADSdOssz
Item
HADS (Hospital Anxiety and Depression Scale) depression subscale SUM
float
C3539657 (UMLS CUI [1,1])
C5188910 (UMLS CUI [1,2])
C1515051 (UMLS CUI [1,3])
HADSaAtl
Item
HADS (Hospital Anxiety and Depression Scale) anxiety subscale MEAN
float
C3539657 (UMLS CUI [1,1])
C5188377 (UMLS CUI [1,2])
C0444504 (UMLS CUI [1,3])
HADSdAtl
Item
HADS (Hospital Anxiety and Depression Scale) depression subscale MEAN
float
C3539657 (UMLS CUI [1,1])
C5188910 (UMLS CUI [1,2])
C0444504 (UMLS CUI [1,3])
HADSaN
Item
Number of answered items of the HADS (Hospital Anxiety and Depression Scale) anxiety subscale
text
C3539657 (UMLS CUI [1,1])
C1822117 (UMLS CUI [1,2])
C5188377 (UMLS CUI [1,3])
HADSdN
Item
Number of answered items of the HADS (Hospital Anxiety and Depression Scale) depression subscale
text
C3539657 (UMLS CUI [1,1])
C1822117 (UMLS CUI [1,2])
C5188910 (UMLS CUI [1,3])
HADS01aF
Item
HADS (Hospital Anxiety and Depression Scale) scale item01 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS03aF
Item
HADS (Hospital Anxiety and Depression Scale) scale item02 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS05aF
Item
HADS (Hospital Anxiety and Depression Scale) scale item03 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS07a
Item
HADS (Hospital Anxiety and Depression Scale) scale item04
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS09a
Item
HADS (Hospital Anxiety and Depression Scale) scale item05
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS11aF
Item
HADS (Hospital Anxiety and Depression Scale) scale item06 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS13aF
Item
HADS (Hospital Anxiety and Depression Scale) scale item07 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS02d
Item
HADS (Hospital Anxiety and Depression Scale) scale item08
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS04d
Item
HADS (Hospital Anxiety and Depression Scale) scale item09
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS06dF
Item
HADS (Hospital Anxiety and Depression Scale) scale item10 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS08dF
Item
HADS (Hospital Anxiety and Depression Scale) scale item11 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS10dF
Item
HADS (Hospital Anxiety and Depression Scale) scale item12 - already reversed
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS12d
Item
HADS (Hospital Anxiety and Depression Scale) scale item13
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
HADS14d
Item
HADS (Hospital Anxiety and Depression Scale) scale item14
text
C3539657 (UMLS CUI [1,1])
C0349674 (UMLS CUI [1,2])
GDNF_rs11111
Item
2668 GDNF gene rs11111 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
GDNF_rs1549250
Item
2668 GDNF gene rs1549250 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
GDNF_rs1981844
Item
2668 GDNF gene rs1981844 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
GDNF_rs2910702
Item
2668 GDNF gene rs2910702 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
GDNF_rs2973041
Item
2668 GDNF gene rs2973041 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
GDNF_rs2973050
Item
2668 GDNF gene rs2973050 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
GDNF_rs3096140
Item
2668 GDNF gene rs3096140 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
GDNF_rs3812047
Item
2668 GDNF gene rs3812047 polymorphism genotype information
string
C1333669 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
C1533716 (UMLS CUI [1,3])
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