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ID

45540

Beschreibung

Principal Investigator: Anna Szekely, PhD, Institute of Psychology, Eötvös Loránd University University, Budapest, Hungary MeSH: Anxiety,Depression https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000713 GDNF gene variants were studied as possible risk factors of depression or anxiety on a young sample. The association study involved eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history. Results provided significant effects of two single nucleotide polymorphisms on anxiety scores following the Bonferroni correction for multiple testing (p=0.00070 and p=0.00138 for rs3812047 and rs3096140, respectively). Haplotype analysis confirmed the role of these SNPs (p=0.00029). A significant sex-gene interaction was also observed since the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males. This is the first demonstration of a significant association between the GDNF gene and mood characteristics demonstrated by the association of two SNPs of the GDNF gene (rs3812047 and rs3096140) and individual variability of anxiety using self-report data from a non-clinical sample. *Reprinted from Kotyuk et. al., 2013* (Kotyuk, E., Keszler, G., Nemeth, N., Ronai, Z., Sasvari-Szekely, M., and Szekely, A. (2013). Glial Cell Line-Derived Neurotrophic Factor (GDNF) as a Novel Candidate Gene of Anxiety. PLoS One,8, (12) PMID: 24324616), *with permission from Publisher* *(All content of articles published in PLOS journals is open access. You can read about our open access license here: http://www.plos.org/about/open-access/. To summarize, this license allows you to download, reuse, reprint, modify, distribute, and/or copy articles or images in PLOS journals, so long as the original creators are credited (e.g., including the article's citation and/or the image credit); Laura Perry; Staff EO;PLOS ONE)*

Link

dbGaP study = phs000713

Stichworte

Versionen (1)
  1. 03.01.23 03.01.23 - Simon Heim
Rechteinhaber

Anna Szekely, PhD, Institute of Psychology, Eötvös Loránd University University, Budapest, Hungary

Hochgeladen am

3. Januar 2023

DOI

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Creative Commons BY 4.0
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    dbGaP phs000713 GDNF and Anxiety

    Englisch

    The dataset provides results of questions from the "Hospital Anxiety and Depression Scale", rs-marker information obtained for the chosen SNP locations (n=8), and basic socio-demographic data.

    5 Formulare  
    pht004273
    Beschreibung

    pht004273

    Alias
    UMLS CUI [1,1]
    C3846158
    De-identified Subject ID
    Beschreibung

    Subject_ID

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C2348585
    Gender of participant
    Beschreibung

    sex

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C0079399
    Subject age
    Beschreibung

    age

    Datentyp

    text

    Maßeinheiten
    • Years
    Alias
    UMLS CUI [1,1]
    C0001779
    Years
    HADS (Hospital Anxiety and Depression Scale) anxiety subscale SUM
    Beschreibung

    HADSaOssz

    Datentyp

    float

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C5188377
    UMLS CUI [1,3]
    C1515051
    HADS (Hospital Anxiety and Depression Scale) depression subscale SUM
    Beschreibung

    HADSdOssz

    Datentyp

    float

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C5188910
    UMLS CUI [1,3]
    C1515051
    HADS (Hospital Anxiety and Depression Scale) anxiety subscale MEAN
    Beschreibung

    HADSaAtl

    Datentyp

    float

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C5188377
    UMLS CUI [1,3]
    C0444504
    HADS (Hospital Anxiety and Depression Scale) depression subscale MEAN
    Beschreibung

    HADSdAtl

    Datentyp

    float

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C5188910
    UMLS CUI [1,3]
    C0444504
    Number of answered items of the HADS (Hospital Anxiety and Depression Scale) anxiety subscale
    Beschreibung

    HADSaN

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C1822117
    UMLS CUI [1,3]
    C5188377
    Number of answered items of the HADS (Hospital Anxiety and Depression Scale) depression subscale
    Beschreibung

    HADSdN

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C1822117
    UMLS CUI [1,3]
    C5188910
    HADS (Hospital Anxiety and Depression Scale) scale item01 - already reversed
    Beschreibung

    HADS01aF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item02 - already reversed
    Beschreibung

    HADS03aF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item03 - already reversed
    Beschreibung

    HADS05aF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item04
    Beschreibung

    HADS07a

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item05
    Beschreibung

    HADS09a

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item06 - already reversed
    Beschreibung

    HADS11aF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item07 - already reversed
    Beschreibung

    HADS13aF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item08
    Beschreibung

    HADS02d

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item09
    Beschreibung

    HADS04d

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item10 - already reversed
    Beschreibung

    HADS06dF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item11 - already reversed
    Beschreibung

    HADS08dF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item12 - already reversed
    Beschreibung

    HADS10dF

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item13
    Beschreibung

    HADS12d

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    HADS (Hospital Anxiety and Depression Scale) scale item14
    Beschreibung

    HADS14d

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C3539657
    UMLS CUI [1,2]
    C0349674
    2668 GDNF gene rs11111 polymorphism genotype information
    Beschreibung

    GDNF_rs11111

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    2668 GDNF gene rs1549250 polymorphism genotype information
    Beschreibung

    GDNF_rs1549250

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    2668 GDNF gene rs1981844 polymorphism genotype information
    Beschreibung

    GDNF_rs1981844

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    2668 GDNF gene rs2910702 polymorphism genotype information
    Beschreibung

    GDNF_rs2910702

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    2668 GDNF gene rs2973041 polymorphism genotype information
    Beschreibung

    GDNF_rs2973041

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    2668 GDNF gene rs2973050 polymorphism genotype information
    Beschreibung

    GDNF_rs2973050

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    2668 GDNF gene rs3096140 polymorphism genotype information
    Beschreibung

    GDNF_rs3096140

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    2668 GDNF gene rs3812047 polymorphism genotype information
    Beschreibung

    GDNF_rs3812047

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1333669
    UMLS CUI [1,2]
    C0032529
    UMLS CUI [1,3]
    C1533716
    Zum Seitenanfang zurückkehren

    Ähnliche Modelle

    The dataset provides results of questions from the "Hospital Anxiety and Depression Scale", rs-marker information obtained for the chosen SNP locations (n=8), and basic socio-demographic data.

    5 Formulare
    Name
    Typ
    Description | Question | Decode (Coded Value)
    Datentyp
    Alias
    Item Group
    pht004273
    C3846158 (UMLS CUI [1,1])
    Subject_ID
    Item
    De-identified Subject ID
    string
    C4684638 (UMLS CUI [1,1])
    C2348585 (UMLS CUI [1,2])
    Item
    Gender of participant
    text
    C0079399 (UMLS CUI [1,1])
    sex
    Code List
    Gender of participant
    CL Item
    Male (1)
    C0086582 (UMLS CUI [1,1])
    CL Item
    Female (2)
    C0086287 (UMLS CUI [1,1])
    age
    Item
    Subject age
    text
    C0001779 (UMLS CUI [1,1])
    HADSaOssz
    Item
    HADS (Hospital Anxiety and Depression Scale) anxiety subscale SUM
    float
    C3539657 (UMLS CUI [1,1])
    C5188377 (UMLS CUI [1,2])
    C1515051 (UMLS CUI [1,3])
    HADSdOssz
    Item
    HADS (Hospital Anxiety and Depression Scale) depression subscale SUM
    float
    C3539657 (UMLS CUI [1,1])
    C5188910 (UMLS CUI [1,2])
    C1515051 (UMLS CUI [1,3])
    HADSaAtl
    Item
    HADS (Hospital Anxiety and Depression Scale) anxiety subscale MEAN
    float
    C3539657 (UMLS CUI [1,1])
    C5188377 (UMLS CUI [1,2])
    C0444504 (UMLS CUI [1,3])
    HADSdAtl
    Item
    HADS (Hospital Anxiety and Depression Scale) depression subscale MEAN
    float
    C3539657 (UMLS CUI [1,1])
    C5188910 (UMLS CUI [1,2])
    C0444504 (UMLS CUI [1,3])
    HADSaN
    Item
    Number of answered items of the HADS (Hospital Anxiety and Depression Scale) anxiety subscale
    text
    C3539657 (UMLS CUI [1,1])
    C1822117 (UMLS CUI [1,2])
    C5188377 (UMLS CUI [1,3])
    HADSdN
    Item
    Number of answered items of the HADS (Hospital Anxiety and Depression Scale) depression subscale
    text
    C3539657 (UMLS CUI [1,1])
    C1822117 (UMLS CUI [1,2])
    C5188910 (UMLS CUI [1,3])
    HADS01aF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item01 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS03aF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item02 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS05aF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item03 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS07a
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item04
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS09a
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item05
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS11aF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item06 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS13aF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item07 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS02d
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item08
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS04d
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item09
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS06dF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item10 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS08dF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item11 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS10dF
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item12 - already reversed
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS12d
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item13
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    HADS14d
    Item
    HADS (Hospital Anxiety and Depression Scale) scale item14
    text
    C3539657 (UMLS CUI [1,1])
    C0349674 (UMLS CUI [1,2])
    GDNF_rs11111
    Item
    2668 GDNF gene rs11111 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
    GDNF_rs1549250
    Item
    2668 GDNF gene rs1549250 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
    GDNF_rs1981844
    Item
    2668 GDNF gene rs1981844 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
    GDNF_rs2910702
    Item
    2668 GDNF gene rs2910702 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
    GDNF_rs2973041
    Item
    2668 GDNF gene rs2973041 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
    GDNF_rs2973050
    Item
    2668 GDNF gene rs2973050 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
    GDNF_rs3096140
    Item
    2668 GDNF gene rs3096140 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
    GDNF_rs3812047
    Item
    2668 GDNF gene rs3812047 polymorphism genotype information
    string
    C1333669 (UMLS CUI [1,1])
    C0032529 (UMLS CUI [1,2])
    C1533716 (UMLS CUI [1,3])
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