ID
45537
Beschreibung
Principal Investigator: Bradley Bernstein, MD, PhD, Massachusetts General Hospital, Boston, MA, USA, Broad Institute, Cambridge, MA, USA MeSH: Nervous System Diseases https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000700 For the NIH Roadmap Epigenomics project, we applied ChlP-Seq, HTBS and WGBS pipelines to generate comprehensive high-resolution maps of chromatin state and DNA methylation for 100 diverse cell types. Cell types were selected for their biological and medical importance, and for their potential to maximize the comprehensiveness of acquired epigenomic data. They include human ES cells, ES-derived cells, mesenchymal stem cells, reprogrammed stem cells and primary tissues. Comprehensive characterization of epigenetic marks ("the epigenome") is a critical step towards a global understanding of the human genome in health and disease. In this study we provide unprecedented views of the human epigenetic landscape and its variation across cell states, which offer fundamental insight into the functions and interrelationships of epigenetic marks, and provide a framework for future studies of normal and diseased epigenomes. *The Roadmap Epigenomics Broad cohort is utilized in the following dbGaP sub-study.* To view molecular data and derived variables collected in this sub-study, please click on the following sub-study below or in the "Sub-studies" box located on the right hand side of this top-level study page phs000700 the Roadmap Epigenomics Broad cohort.- phs000610 RM_Epigenomics_Broad_Alz
Link
Stichworte
Versionen (1)
- 29.12.22 29.12.22 - Simon Heim
Rechteinhaber
Bradley Bernstein, MD, PhD, Massachusetts General Hospital, Boston, MA, USA, Broad Institute, Cambridge, MA, USA
Hochgeladen am
29. Dezember 2022
DOI
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Lizenz
Creative Commons BY 4.0
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dbGaP phs000700 RoadmapEpigenomics_Broad
Sample ID, and GEO accession ID of participants of the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, age, sex, and diagnosis of participants with Alzheimer disease and involved in the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- Sample ID, and GEO accession ID of participants of the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- Sample ID, histological type, collection method, body site where sample was obtained, analyte type, and tumor status of sample obtained from participants with Alzheimer disease and involved in the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- Subject ID, subject source, source subject ID, and consent group of participants with Alzheimer disease and involved in the "NIH Roadmap Epigenomics Program - Broad Institute" project.
- Subject ID, sample ID, sample source, source sample ID, sample use, and study of participants with Alzheimer disease and involved in the "NIH Roadmap Epigenomics Program - Broad Institute" project.
Ähnliche Modelle
Sample ID, and GEO accession ID of participants of the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, age, sex, and diagnosis of participants with Alzheimer disease and involved in the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- Sample ID, and GEO accession ID of participants of the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- Sample ID, histological type, collection method, body site where sample was obtained, analyte type, and tumor status of sample obtained from participants with Alzheimer disease and involved in the "Roadmap Epigenomics Program - Broad Alzheimer Disease and Age-Related" project.
- Subject ID, subject source, source subject ID, and consent group of participants with Alzheimer disease and involved in the "NIH Roadmap Epigenomics Program - Broad Institute" project.
- Subject ID, sample ID, sample source, source sample ID, sample use, and study of participants with Alzheimer disease and involved in the "NIH Roadmap Epigenomics Program - Broad Institute" project.