ID
45535
Descripción
Principal Investigator: Kendall Van Keuren-Jensen, PhD, The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA MeSH: Alzheimer Disease,Parkinson Disease https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000727 We profiled the miRNA contents from cerebrospinal fluid and serum (using next generation sequencing) from postmortem patients diagnosed with Alzheimer's or Parkinson's disease, and neurologically normal controls. All biofluids were cell-free and patient matched, there was one cerebrospinal fluid and one serum sample from each of 70 patients with Alzheimer's disease, 67 patients with Parkinson's disease and 78 age-similar controls. We correlated the miRNA changes with measurements of neuropathology such as plaques, tangles and Lewy bodies.
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Versiones (1)
- 2022-12-28 2022-12-28 - Chiara Middel
Titular de derechos de autor
Kendall Van Keuren-Jensen, PhD, The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA
Subido en
28 december 2022
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs000727 miRNA profiles in serum and CSF of Parkinson's and Alzheimer's patients
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject - Consent - Affection Status Information
- Subject - Sample Mapping
- The dataset provides information about disease duration, presence of APOE alleles, time interval between death and tissue harvest, location and extend of plaque and tangle formation, degree of Substantia Nigra depigmentation and status of Lewy body formation observed, Braak/NIA-Reagan scores and general sociodemographic information.
- Sample Attribute Information
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject - Consent - Affection Status Information
- Subject - Sample Mapping
- The dataset provides information about disease duration, presence of APOE alleles, time interval between death and tissue harvest, location and extend of plaque and tangle formation, degree of Substantia Nigra depigmentation and status of Lewy body formation observed, Braak/NIA-Reagan scores and general sociodemographic information.
- Sample Attribute Information
C0680251 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,2])
C0002395 (UMLS CUI [1,3])
C0332145 (UMLS CUI [1,4])
C0876934 (UMLS CUI [1,5])
C0679228 (UMLS CUI [1,6])
C0027853 (UMLS CUI [2,1])
C0205307 (UMLS CUI [2,2])