ID

45533

Description

Principal Investigator: Jose Florez, Massachusetts General Hospital, Boston, MA, USA MeSH: Diabetes Mellitus, Type 2 https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000681 The Diabetes Prevention Program (DPP) was a multicenter controlled clinical trial examining the efficacy of an intensive lifestyle intervention or metformin to prevent or delay the development of diabetes in a population selected to be at high risk due to the presence of impaired glucose tolerance (IGT) and obesity. Development of diabetes, defined by 1997 American Diabetes Association (ADA) criteria, was the primary outcome while cardiovascular disease and its risk factors were important secondary outcomes. The pharmacological intervention was double blinded and placebo controlled. After randomization, participants had quarterly clinical evaluations and had, in addition, a fasting plasma glucose at semi-annual visits and a 75 gram oral glucose tolerance test at annual visits. Volunteers were recruited from populations known to be at particularly high risk for impaired glucose tolerance and type 2 diabetes including the following: persons with a family history of NIDDM, the elderly, overweight individuals, women with a history of diabetes during pregnancy ("gestational diabetes"), and minority populations including African Americans, Hispanic Americans, Asian and Pacific Island Americans, and Native Americans. The primary focus of the genetic investigations have been on candidate genes, including candidates derived from GWAS of diabetes, lipid and glycemia-related phenotypes. *Please note* more phenotype data for the DPPG cohort is available through the NIDDK Data Repository. Information on obtaining this phenotype data can be found by going to https://www.niddkrepository.org/studies/dppos/?query=DPP and https://www.niddkrepository.org/studies/dpp/?query=DPP. Data will need to be requested from both data sets. A linking file will be available to the NIDDK Data Repository.

Link

dbGaP study = phs000681

Keywords

Versions (1)
  1. 12/28/22 12/28/22 - Simon Heim
Copyright Holder

Jose Florez, Massachusetts General Hospital, Boston, MA, USA

Uploaded on

December 28, 2022

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000681 Diabetes Prevention Program Genetics (DPPG)

English

Eligibility Criteria

5 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
In order to be eligible, persons who were older than 25 years with a body mass index ≥24 kg/m2 (≥22 kg/m2 in Asian-Americans) had demonstrated impaired glucose tolerance with plasma glucose levels 95-125 mg/dL (5.3-6.9 mmol/L) fasting and 140- 199 mg/dL (7.8 - 11.0 mmol/L) two hours after a 75 gram oral glucose tolerance test. Individuals with conditions or treatments that would interfere with participation in or completion of the protocol, or that have a confounding effect on the measurement of the primary outcomes of the study were excluded. A detailed list of inclusion and exclusion criteria can be found in http://www.bsc.gwu.edu/dpp/protocol.htmlvdoc.
Description

In order to be eligible, persons who were older than 25 years with a body mass index ≥24 kg/m2 (≥22 kg/m2 in Asian-Americans) had demonstrated impaired glucose tolerance with plasma glucose levels 95-125 mg/dL (5.3-6.9 mmol/L) fasting and 140- 199 mg/dL (7.8 - 11.0 mmol/L) two hours after a 75 gram oral glucose tolerance test. Individuals with conditions or treatments that would interfere with participation in or completion of the protocol, or that have a confounding effect on the measurement of the primary outcomes of the study were excluded. A detailed list of inclusion and exclusion criteria can be found in http://www.bsc.gwu.edu/dpp/protocol.htmlvdoc.

Data type

boolean

Alias
UMLS CUI [1,1]
C0013893
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0680251
UMLS CUI [1,4]
C0271650
UMLS CUI [1,5]
C0017741
UMLS CUI [1,6]
C0001779
UMLS CUI [1,7]
C1305855
UMLS CUI [1,8]
C0348080
UMLS CUI [1,9]
C0087111
UMLS CUI [1,10]
C0521102
UMLS CUI [1,11]
C0030699
UMLS CUI [1,12]
C0947630
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Similar models

Eligibility Criteria

5 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
In order to be eligible, persons who were older than 25 years with a body mass index ≥24 kg/m2 (≥22 kg/m2 in Asian-Americans) had demonstrated impaired glucose tolerance with plasma glucose levels 95-125 mg/dL (5.3-6.9 mmol/L) fasting and 140- 199 mg/dL (7.8 - 11.0 mmol/L) two hours after a 75 gram oral glucose tolerance test. Individuals with conditions or treatments that would interfere with participation in or completion of the protocol, or that have a confounding effect on the measurement of the primary outcomes of the study were excluded. A detailed list of inclusion and exclusion criteria can be found in http://www.bsc.gwu.edu/dpp/protocol.htmlvdoc.
Item
In order to be eligible, persons who were older than 25 years with a body mass index ≥24 kg/m2 (≥22 kg/m2 in Asian-Americans) had demonstrated impaired glucose tolerance with plasma glucose levels 95-125 mg/dL (5.3-6.9 mmol/L) fasting and 140- 199 mg/dL (7.8 - 11.0 mmol/L) two hours after a 75 gram oral glucose tolerance test. Individuals with conditions or treatments that would interfere with participation in or completion of the protocol, or that have a confounding effect on the measurement of the primary outcomes of the study were excluded. A detailed list of inclusion and exclusion criteria can be found in http://www.bsc.gwu.edu/dpp/protocol.htmlvdoc.
boolean
C0013893 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,3])
C0271650 (UMLS CUI [1,4])
C0017741 (UMLS CUI [1,5])
C0001779 (UMLS CUI [1,6])
C1305855 (UMLS CUI [1,7])
C0348080 (UMLS CUI [1,8])
C0087111 (UMLS CUI [1,9])
C0521102 (UMLS CUI [1,10])
C0030699 (UMLS CUI [1,11])
C0947630 (UMLS CUI [1,12])
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