ID
45529
Description
Principal Investigator: Lisa Cannon Albright, PhD, The University of Utah, UT, USA MeSH: Prostate cancer, familial https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000733 Initially, the ICPCG focused largely on high-risk prostate cancer pedigrees using linkage analysis. However, association studies have also been informative to find prostate cancer susceptibility variants in the genome. We hypothesize that genome-wide (GW) association studies of familial cases of prostate cancer will have the power to identify rarer and perhaps less penetrant risk variants associated with prostate cancer than have been identified to date. Our approach will be to examine evidence for association in selected, independent cases from high-risk pedigrees; we hypothesize that they represent a more homogeneous set of cases with potentially different associations. Use of the 5M plus exome SNP platform will allow us to include in our search more rare variants in our search than have ever been investigated for prostate cancer. *Aim 1. *Identify a set of independent prostate cancer cases selected from ICPCG high-risk prostate cancer pedigrees that have 3 or more related prostate cancer cases and have an average age at diagnosis ≤ 75 years. Identify appropriate matched controls from participating ICPCG groups/ populations. *Aim 2. *Perform GW SNP genotyping with the Illumina 5M plus exome SNP set on the set of independent prostate cancer cases and controls described in Aim 1. *Aim 3. *Perform association analyses appropriately matching controls for different ICPCG populations and groups. There will be a two-stage design for confirmation. *Aim 4. *Test reported associations using the extensive sample set available to us by collaboration with the PRACTICAL consortium that has access to 50 000 DNA samples from 34 groups internationally *(over 7,000 of whom are positive for prostate cancer family history).*
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Versions (1)
- 12/27/22 12/27/22 - Chiara Middel
Copyright Holder
Lisa Cannon Albright, PhD, The University of Utah, UT, USA
Uploaded on
December 27, 2022
DOI
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License
Creative Commons BY 4.0
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dbGaP phs000733 ICPCG Genome Wide Association Study of Familial Prostate Cancer
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
- Subject ID and sample ID of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
- Subject ID, sex, age of prostate cancer diagnosis, aggressiveness of prostate cancer, race, family history of prostate cancer, and ICPCG Institution of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
- Sample ID, body site where sample was obtained, analyte type, histological type of sample, tumor status of sample, DNA source, and DNA extraction method of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
- Subject ID and sample ID of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
- Subject ID, sex, age of prostate cancer diagnosis, aggressiveness of prostate cancer, race, family history of prostate cancer, and ICPCG Institution of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
- Sample ID, body site where sample was obtained, analyte type, histological type of sample, tumor status of sample, DNA source, and DNA extraction method of participants with or without prostate cancer and involved in the "The International Consortium for Prostate Cancer Genetics Genome Wide Association Study of Familial Prostate Cancer" project.
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