ID
45521
Description
Principal Investigator: Todd Golub, Dana Farber Cancer Institute, Boston, MA, USA MeSH: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000699 In this study we attempt to elucidate the genomic characteristics of osteosarcoma. *Clinical characteristics* 58 tumor / normal pairs from 58 patients were included in the study. Median age at diagnosis was 12 years. 49% of the patients were male and 47% had metastases at diagnosis. 5 year overall survival was 49% for the entire population, 33% for patients with metastatic disease and 64% for patients with localized disease. Patients with metastatic disease at diagnosis had a significantly worse overall survival. All cases except 2 were sporadic and no patients had stigmata of Rothmund-Thomson, Bloom's or Werner's syndromes or Paget's disease. Two familial cases were affected siblings from a family in which there were 2 unaffected parents and 2 unaffected siblings. None of the patients had known Li Fraumeni or hereditary retinoblastoma. *Sample Selection and Clinical Data* Samples were contributed by hospitals in Brazil, Spain, Mexico and the United States. All patients had histopathology confirmed to be osteosarcoma by a pathologist at the local institution. All but 5 tumor specimens sequenced were obtained pre-chemotherapy from the primary tumor at the time of diagnosis. 2 tumor specimens were obtained pre-chemotherapy from a metastatic tumor at the time of diagnosis. 3 tumor specimens were obtained post-chemotherapy from a metastatic tumor.
Link
Keywords
Versions (1)
- 12/14/22 12/14/22 - Simon Heim
Copyright Holder
Todd Golub, Dana Farber Cancer Institute, Boston, MA, USA
Uploaded on
December 14, 2022
DOI
To request one please log in.
License
Creative Commons BY 4.0
Model comments :
You can comment on the data model here. Via the speech bubbles at the itemgroups and items you can add comments to those specificially.
Itemgroup comments for :
Item comments for :
In order to download data models you must be logged in. Please log in or register for free.
dbGaP phs000699 Osteosarcoma Genomics
This data table contains subject IDs and consent group information.
- StudyEvent: SEV1
- This data table contains subject IDs and consent group information.
- This data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table contains gender, age at diagnosis, months of survival since diagnosis, survival status, and locus of metastic tumor.
- This sample attributes data table includes analyte type and tumor status.
Similar models
This data table contains subject IDs and consent group information.
- StudyEvent: SEV1
- This data table contains subject IDs and consent group information.
- This data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table contains gender, age at diagnosis, months of survival since diagnosis, survival status, and locus of metastic tumor.
- This sample attributes data table includes analyte type and tumor status.