ID
45515
Description
Principal Investigator: Levi A. Garraway, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA and Broad Institute of Harvard and MIT, Cambridge, MA, USA MeSH: Colorectal Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000722 Colorectal cancer is a molecularly heterogeneous disease. Whole Exome Sequencing from patients diagnosed with colorectal cancer in the NHS and HPFS cohorts will extend our understanding of the genetic changes occurring in specific clinical contexts in the disease. This effort has the potential to discover novel recurrently mutated genes and pathways in colorectal cancer that can be functionally validated and give further insights to colorectal cancer pathogenesis. All exome sequencing was performed at the Broad Institute of Harvard and MIT; samples sequence capture was performed using Agilent SureSelect Human All Exon Kit v2 and sequencing was performed on an Illumina HiSeq 2000.
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Mots-clés
Versions (1)
- 13/12/2022 13/12/2022 - Simon Heim
Détendeur de droits
Levi A. Garraway, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA and Broad Institute of Harvard and MIT, Cambridge, MA, USA
Téléchargé le
13 décembre 2022
DOI
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Licence
Creative Commons BY 4.0
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dbGaP phs000722 DFCI Colorectal Cancer Cohorts
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent information.
- The subject sample mapping data table includes a mapping of study subject IDs to sample IDs. dbGaP samples are defined as the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table includes gender of participants.
- This sample attributes table includes tumor status and analyte type.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent information.
- The subject sample mapping data table includes a mapping of study subject IDs to sample IDs. dbGaP samples are defined as the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table includes gender of participants.
- This sample attributes table includes tumor status and analyte type.
C0680251 (UMLS CUI [1,2])
C0030705 (UMLS CUI [1,2])
C0027461 (UMLS CUI [1,3])
C0205540 (UMLS CUI [1,4])
C2603343 (UMLS CUI [1,5])