ID
45511
Descrição
Principal Investigator: Sharon A. Savage, MD, National Institutes of Health, Bethesda, MD, USA MeSH: Osteosarcoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000734 This is a genome-wide association study (GWAS) of osteosarcoma, the most common primary bone malignancy. Osteosarcoma typically occurs in adolescents and young adults. It occurs at increased frequency in several inherited cancer predisposition syndromes but the genetic contribution to sporadic osteosarcoma is largely unexplored. The objective of this study was to identify genetic risk factors for osteosarcoma by conducting a genome-wide association study. We developed collaborations with multiple institutions in order to attain the necessary sample size required to discover novel loci in the genome associated with osteosarcoma using the GWAS approach. Genomic DNA (either blood or buccal in source) derived from osteosarcoma cases was obtained from each participating institution or research group. De-identified blood or buccal cell DNA samples from osteosarcoma cases were derived from existing biobanks at the collaborative institutions. Control subjects were derived from existing NCI cohorts and matched by gender and ethnicity.
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Versões (1)
- 13/12/2022 13/12/2022 - Simon Heim
Titular dos direitos
Sharon A. Savage, MD, National Institutes of Health, Bethesda, MD, USA
Transferido a
13 de dezembro de 2022
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs000734 Osteosarcoma Genome-wide Association Study
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
- Subject ID, sample ID, and sample use variable obtained from participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
- Subject ID, sex, case or control, and country origin of participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
- Subject ID, sample ID, and sample use variable obtained from Sample ID, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
- Subject ID, sample ID, and sample use variable obtained from participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
- Subject ID, sex, case or control, and country origin of participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
- Subject ID, sample ID, and sample use variable obtained from Sample ID, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants with osteosarcoma and involved in the "A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma" project.
C0680251 (UMLS CUI [1,2])
C1706256 (UMLS CUI [1,2])
C4543929 (UMLS CUI [1,3])