ID
45509
Descripción
Principal Investigator: Marie-Claude Gingras, PhD, Baylor College of Medicine, Human Genome Sequencing Center, Houston, TX, USA MeSH: Carcinoma, Hepatocellular https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000509 Hepatocellular carcinoma (HCC) accounts for 85-90% of primary liver cancers. We have focused on three major HCC etiologies:hepatitis C virus (HCV), hepatitis B virus (HBV), and nonviral causes. The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. We combined our capability to capture and enrich exome DNA with the next generation sequencing capacity to allow us to detect and characterize the somatic mutation profile of patients with HCC. Patient samples were collected by the Liver Center, Division of Abdominal Transplantation in the Baylor College of Medicine Department of Surgery. Sequencing of HCC is one of the NHGRI Center Initiated Projects in progress in the Human Genome Sequencing Center at Baylor College of Medicine.
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Versiones (2)
- 2022-10-14 2022-10-14 - Chiara Middel
- 2022-12-13 2022-12-13 - Kristina Keller
Titular de derechos de autor
Marie-Claude Gingras, PhD, Baylor College of Medicine, Human Genome Sequencing Center, Houston, TX, USA
Subido en
13 december 2022
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs000509 Genome Sequencing of Hepatocellular Carcinoma
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
- Subject ID, sample ID, sample source, source subject ID, and sample use variable obtained from participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
- Subject ID, race, gender, age at initial diagnosis, date of surgery, diagnosis of hepatitis B, C, and alcohol cirrhosis of participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
- Sample ID, sample type, histology of sample, and sample analyte type of participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
- Subject ID, sample ID, sample source, source subject ID, and sample use variable obtained from participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
- Subject ID, race, gender, age at initial diagnosis, date of surgery, diagnosis of hepatitis B, C, and alcohol cirrhosis of participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
- Sample ID, sample type, histology of sample, and sample analyte type of participants with hepatocellular carcinoma and involved in the "Genome Sequencing of Hepatocellular Carcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)" project.
C0011008 (UMLS CUI [1,2])
C0040732 (UMLS CUI [1,3])
C0021430 (UMLS CUI [2,1])
C0679823 (UMLS CUI [2,2])
C0887950 (UMLS CUI [2,3])
C0035168 (UMLS CUI [2,4])
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