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ID

45474

Description

Principal Investigator: E. Ann Coleman, University of Arkansas for Medical Sciences Little Rock, Arkansas, USA MeSH: Multiple Myeloma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000545 We hypothesized that genetic variability in the enzymes/proteins involved in drug metabolism, inflammation, and immune function is a major underlying contributor to mucositis incidence and progression and that, based on this variability we can identify variants that influence risk, and develop a mucositis progression prediction model that improves on existing models by incorporating genetic variability along with clinical factors. Using genome wide association study (GWAS) combined with a pathway candidate gene approach and a modified case-control study method, we investigated the hypothesis in a sample of 1092 patients who received a myeloablative dose of melphalan (MEL) followed by autologous hematopoietic stem cell (ASCT) transplantation as treatment for multiple myeloma and for whom banked blood stem cell samples and clinical data were available.

Link

dbGap study = phs000545

Keywords

Versions (2)
  1. 10/31/22 10/31/22 - Simon Heim
  2. 12/13/22 12/13/22 - Kristina Keller
Copyright Holder

E. Ann Coleman, University of Arkansas for Medical Sciences Little Rock, Arkansas, USA

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December 13, 2022

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Creative Commons BY 4.0
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    dbGaP phs000545 Predicting Chemotherapy-Induced Mucositis with Genetic and Clinical Factors

    English

    Subject ID, age, type of cancer, BMI, body surface area, weight, gender, race, hematocrit, hemoglobin, GFR, creatinine, albumin, c-reactive protein, Melphelan dose, beta-microglobulin, myeloma isotype, mucositis grade, and CMV of participants involved in the "Predicting Chemotherapy-Induced Mucositis with Genetic and Clinical Factors" project.

    5 forms  
    pht003764
    Description

    pht003764

    De-identified ID
    Description

    PublicID

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C2348585
    Age at treatment (years)
    Description

    age

    Data type

    text

    Measurement units
    • Years
    Alias
    UMLS CUI [1,1]
    C4085942
    Years
    Type of cancer
    Description

    cancertype

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C4743729
    Body Mass Index (kg/m**2)
    Description

    bmi

    Data type

    float

    Measurement units
    • kg/m**2
    Alias
    UMLS CUI [1,1]
    C1305855
    kg/m**2
    Body surface area (m**2)
    Description

    bsa

    Data type

    float

    Measurement units
    • m**2
    Alias
    UMLS CUI [1,1]
    C0005902
    m**2
    Weight (kgs)
    Description

    wt_kg

    Data type

    float

    Measurement units
    • kg
    Alias
    UMLS CUI [1,1]
    C0005910
    kg
    Gender
    Description

    gender

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0079399
    Race
    Description

    race

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0034510
    Hematocrit (%)
    Description

    hct

    Data type

    float

    Measurement units
    • %
    Alias
    UMLS CUI [1,1]
    C0518014
    %
    Hemoglobin (g/dL)
    Description

    hb

    Data type

    float

    Measurement units
    • g/dL
    Alias
    UMLS CUI [1,1]
    C0019046
    UMLS CUI [1,2]
    C1274040
    UMLS CUI [1,3]
    C0022885
    UMLS CUI [1,4]
    C1522609
    g/dL
    Estimated GFR (ml/min)
    Description

    est_gfr

    Data type

    float

    Measurement units
    • ml/min
    Alias
    UMLS CUI [1,1]
    C3811844
    ml/min
    Serum creatinine (mg/dL)
    Description

    cr

    Data type

    float

    Measurement units
    • mg/dL
    Alias
    UMLS CUI [1,1]
    C0600061
    mg/dL
    Creatinine Clearance (ml/min)
    Description

    crcl

    Data type

    float

    Measurement units
    • ml/min
    Alias
    UMLS CUI [1,1]
    C0373595
    ml/min
    Albumin (g/dL)
    Description

    alb

    Data type

    float

    Measurement units
    • g/dL
    Alias
    UMLS CUI [1,1]
    C0363885
    g/dL
    C-reactive protein (mg/L)
    Description

    crp

    Data type

    float

    Measurement units
    • mg/L
    Alias
    UMLS CUI [1,1]
    C0006560
    mg/L
    Melphelan dose (mg/kg)
    Description

    mg_kg

    Data type

    float

    Measurement units
    • mg/kg
    Alias
    UMLS CUI [1,1]
    C0025241
    UMLS CUI [1,2]
    C3174092
    mg/kg
    Beta-microglobulin
    Description

    b2m

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C0201910
    Myeloma Isotype
    Description

    isotype

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0026764
    UMLS CUI [1,2]
    C0021017
    Upper GI mucositis grade
    Description

    ugr

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0521585
    UMLS CUI [1,2]
    C3203348
    Lower GI mucositis grade
    Description

    lgr

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0521585
    UMLS CUI [1,2]
    C0226875
    Presence of C. difficile
    Description

    cdiff

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C4687402
    CMV reactive
    Description

    cmv_rea

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0010825
    UMLS CUI [1,2]
    C0205332
    CMV serostatus
    Description

    cmv_sero

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0582172
    Upper GI mucositis case control
    Description

    case_control_upperGI

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C3203348
    UMLS CUI [1,2]
    C0521585
    UMLS CUI [1,3]
    C0872128
    Lower GI mucositis case control
    Description

    case_control_lowerGI

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0226875
    UMLS CUI [1,2]
    C0521585
    UMLS CUI [1,3]
    C0872128
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    Similar models

    Subject ID, age, type of cancer, BMI, body surface area, weight, gender, race, hematocrit, hemoglobin, GFR, creatinine, albumin, c-reactive protein, Melphelan dose, beta-microglobulin, myeloma isotype, mucositis grade, and CMV of participants involved in the "Predicting Chemotherapy-Induced Mucositis with Genetic and Clinical Factors" project.

    5 forms
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    pht003764
    PublicID
    Item
    De-identified ID
    text
    C4684638 (UMLS CUI [1,1])
    C2348585 (UMLS CUI [1,2])
    age
    Item
    Age at treatment (years)
    text
    C4085942 (UMLS CUI [1,1])
    cancertype
    Item
    Type of cancer
    string
    C4743729 (UMLS CUI [1,1])
    bmi
    Item
    Body Mass Index (kg/m**2)
    float
    C1305855 (UMLS CUI [1,1])
    bsa
    Item
    Body surface area (m**2)
    float
    C0005902 (UMLS CUI [1,1])
    wt_kg
    Item
    Weight (kgs)
    float
    C0005910 (UMLS CUI [1,1])
    gender
    Item
    Gender
    string
    C0079399 (UMLS CUI [1,1])
    race
    Item
    Race
    string
    C0034510 (UMLS CUI [1,1])
    hct
    Item
    Hematocrit (%)
    float
    C0518014 (UMLS CUI [1,1])
    hb
    Item
    Hemoglobin (g/dL)
    float
    C0019046 (UMLS CUI [1,1])
    C1274040 (UMLS CUI [1,2])
    C0022885 (UMLS CUI [1,3])
    C1522609 (UMLS CUI [1,4])
    est_gfr
    Item
    Estimated GFR (ml/min)
    float
    C3811844 (UMLS CUI [1,1])
    cr
    Item
    Serum creatinine (mg/dL)
    float
    C0600061 (UMLS CUI [1,1])
    crcl
    Item
    Creatinine Clearance (ml/min)
    float
    C0373595 (UMLS CUI [1,1])
    alb
    Item
    Albumin (g/dL)
    float
    C0363885 (UMLS CUI [1,1])
    crp
    Item
    C-reactive protein (mg/L)
    float
    C0006560 (UMLS CUI [1,1])
    mg_kg
    Item
    Melphelan dose (mg/kg)
    float
    C0025241 (UMLS CUI [1,1])
    C3174092 (UMLS CUI [1,2])
    b2m
    Item
    Beta-microglobulin
    float
    C0201910 (UMLS CUI [1,1])
    isotype
    Item
    Myeloma Isotype
    string
    C0026764 (UMLS CUI [1,1])
    C0021017 (UMLS CUI [1,2])
    ugr
    Item
    Upper GI mucositis grade
    text
    C0521585 (UMLS CUI [1,1])
    C3203348 (UMLS CUI [1,2])
    lgr
    Item
    Lower GI mucositis grade
    text
    C0521585 (UMLS CUI [1,1])
    C0226875 (UMLS CUI [1,2])
    cdiff
    Item
    Presence of C. difficile
    string
    C4687402 (UMLS CUI [1,1])
    Item
    CMV reactive
    text
    C0010825 (UMLS CUI [1,1])
    C0205332 (UMLS CUI [1,2])
    cmv_rea
    Code List
    CMV reactive
    CL Item
    Not done (ND)
    CL Item
    Negative (NEG)
    CL Item
    Positive (POS)
    Item
    CMV serostatus
    text
    C0582172 (UMLS CUI [1,1])
    cmv_sero
    Code List
    CMV serostatus
    CL Item
    Negative (NEG)
    CL Item
    Positive (POS)
    case_control_upperGI
    Item
    Upper GI mucositis case control
    text
    C3203348 (UMLS CUI [1,1])
    C0521585 (UMLS CUI [1,2])
    C0872128 (UMLS CUI [1,3])
    case_control_lowerGI
    Item
    Lower GI mucositis case control
    text
    C0226875 (UMLS CUI [1,1])
    C0521585 (UMLS CUI [1,2])
    C0872128 (UMLS CUI [1,3])
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