ID
45450
Descrição
Principal Investigator: Eden R. Martin, University of Miami, Miami, FL, USA MeSH: Population Groups https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000750 The GOAL Study was designed to comprehensively evaluate the genomic architecture of diverse Hispanic/Latino individuals with origins from the Caribbean, Central and South America, and to understand the impact of this diversity on genetic disease studies. Population structure and admixture are key confounders in genome-wide association and medical resequencing studies. In particular, accounting for difference in ancestry among cases and controls, both in terms of genomic and geographic location, is critical for proper analysis and interpretation of studies with multi- and trans-ethnic samples. Genomic studies of Hispanics/Latinos, the largest and fastest growing minority group in the US, reveal that they are a highly genetically heterogeneous admixed group with immense variation among individuals and populations in the proportions of African, European, and Native American ancestry. Knowledge of the underlying complex genetic structure of US Hispanic/Latino and Caribbean populations is, therefore, essential to ensuring robustness of genotype-phenotype associations and understanding the medical relevance of associated variants across diverse populations in the US and throughout the Americas. Furthermore, since much is known about the African and European migrations into the Americas over the past 500 years, population genetic studies of Hispanics/Latinos serve as an excellent model for developing novel algorithms and approaches for characterizing fine-scale genetic structure of admixed populations, in general. This project extends current studies of population genetic structure in US Hispanics/Latinos by densely genotyping parent-offspring triads from individuals (sampled in the US) of Caribbean-descent from six Latin American countries: Puerto Rico, Cuba, Dominican Republic, Haiti, Honduras and Colombia. This study will provide immediate insights and new statistical methods to improve study design and genetic analysis for medical genomic studies in Hispanics/Latinos, other complex admixed groups, and multi- and trans-ethnic studies.
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Versões (1)
- 10/12/2022 10/12/2022 - Chiara Middel
Titular dos direitos
Eden R. Martin, University of Miami, Miami, FL, USA
Transferido a
10 de dezembro de 2022
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs000750 Genomic Origins and Admixture in Latinos (GOAL)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent information.
- The pedigree table includes subject ID, family ID, father and mother ID, and subject gender to link subjects of the same family.
- This data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table includes subject gender, race, ethnicity, and country of origin.
- This sample attributes table includes body site where sample was extracted, analyte type, tumor status, and, histological type.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent information.
- The pedigree table includes subject ID, family ID, father and mother ID, and subject gender to link subjects of the same family.
- This data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table includes subject gender, race, ethnicity, and country of origin.
- This sample attributes table includes body site where sample was extracted, analyte type, tumor status, and, histological type.
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C0337471 (UMLS CUI [3,3])
C0543488 (UMLS CUI [3,4])
C0454664 (UMLS CUI [3,5])
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C0242800 (UMLS CUI [1,3])