ID
45448
Description
Principal Investigator: Chris Amos, PhD, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA MeSH: Lung Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000753 This research builds upon an extensive resource of a case-control study that has been ongoing at the UT MD Anderson Cancer Center since 1991. To identify risk variants for lung cancer, we conducted a genome-wide association study. Cases are newly diagnosed, histologically-confirmed patients presenting at MD Anderson Cancer and who had not previously received treatment other than surgery. Controls are healthy individuals seen for routine care at Kelsey-Seybold Clinics, the largest physician group-practice plan in the Houston Metropolitan area. This lung GWAS led to the identification of a susceptibility locus for lung cancer at 15q25.1. We used data from 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston, Texas in the discovery followed by the replication of the ten SNPs most significantly associated with lung cancer in an additional 711 cases and 632 controls from Texas and 2,013 cases and 3,062 controls from the UK. Two SNPs, rs1051730 and rs8034191, were significantly associated with risk of lung cancer with combined analysis yielded odds ratios of 1.32 (P 1X10-17) for both SNPs. These two SNPs mapped to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5. (Nat Genet. 2008 May;40(5):616-22. PMID:18385676)
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Versions (1)
- 12/7/22 12/7/22 - Chiara Middel
Copyright Holder
Chris Amos, PhD, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA
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December 7, 2022
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Creative Commons BY 4.0
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dbGaP phs000753 High Density SNP Association Analysis of Lung Cancer
Subject ID, case or control, age, sex, race, and smoking status of participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- Subject ID, case or control, age, sex, race, and smoking status of participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- Sample ID, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
Similar models
Subject ID, case or control, age, sex, race, and smoking status of participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- Subject ID, case or control, age, sex, race, and smoking status of participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
- Sample ID, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants with or without lung cancer and involved in the "High Density SNP Association Analysis of Lung Cancer" project.
C2348585 (UMLS CUI [1,2])
C0012634 (UMLS CUI [1,2])