Information:
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ID
45444
Description
Principal Investigator: Scott Boyd, MD, PhD, Stanford University, Palo Alto, CA, USA MeSH: Influenza Vaccines https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000760 The data consist of the DNA sequences of antibody gene rearrangements from peripheral blood human B cells of subjects vaccinated with trivalent seasonal influenza or monovalent pandemic H1N1 vaccine. Multiple replicate libraries of immunoglobulin heavy chain gene rearrangements were prepared from each subject for each time point.
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Keywords
Versions (1)
- 12/7/22 12/7/22 - Chiara Middel
Copyright Holder
Scott Boyd, MD, PhD, Stanford University, Palo Alto, CA, USA
Uploaded on
December 7, 2022
DOI
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License
Creative Commons BY 4.0
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dbGaP phs000760 Human Responses to Influenza Vaccination
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent information.
- This data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table includes subject's sex, age group, self-reported flu infection and vaccination, and influenza seroconversion status.
- This sample attributes table includes tissue type, analyte type, vaccination type, and days following vaccination when sample was taken.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent information.
- This data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table includes subject's sex, age group, self-reported flu infection and vaccination, and influenza seroconversion status.
- This sample attributes table includes tissue type, analyte type, vaccination type, and days following vaccination when sample was taken.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
Elig.phs000760.v1.p1.1
Item
The seven healthy vaccine seroconverter subjects and seven healthy non-seroconverter subjects in the study were recruited at Duke University and were given TIV (Sanofi Pasteur, Swiftwater PA): 2007-2008 Fluzone® vaccine or 2008-2009 Fluzone® vaccine. Blood samples were collected prior to vaccination and on days seven and twenty-one after vaccination. Subject BFI-278 recruited at Stanford University was administered Influenza A (H1N1) 2009 monovalent inactivated vaccination in January 2010. Blood was collected immediately prior to vaccination and on days four to fourteen after vaccination. Ten months after receiving the monovalent H1N1 vaccine, BFI-278 was administered a seasonal trivalent inactivated vaccine that included the Influenza A/California/07/2009-like pandemic H1N1 antigenic component. Blood was drawn from BFI-278 prior to 2010 TIV vaccination, and at days seven and twenty-one post-vaccination.
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C0042196 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
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C1277698 (UMLS CUI [3,1])
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C0332152 (UMLS CUI [3,3])
C0042196 (UMLS CUI [3,4])
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C0011008 (UMLS CUI [4,6])
C0332152 (UMLS CUI [4,7])
C0042196 (UMLS CUI [4,8])
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C4082118 (UMLS CUI [4,10])
C0681850 (UMLS CUI [5,1])
C0242800 (UMLS CUI [5,2])
C0205394 (UMLS CUI [5,3])
C0019994 (UMLS CUI [5,4])
C1524062 (UMLS CUI [5,5])
C0042196 (UMLS CUI [5,6])
C1277698 (UMLS CUI [5,7])
C0011008 (UMLS CUI [5,8])
C0332152 (UMLS CUI [5,9])
C0042196 (UMLS CUI [5,10])
C3842672 (UMLS CUI [5,11])
C4082109 (UMLS CUI [5,12])