ID
45442
Beskrivning
Principal Investigator: Nenad Sestan, MD, PhD, Yale University, New Haven, CT, USA MeSH: Brain Diseases,Growth and Development,Aging https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000755 The NIH-funded BrainSpan (www.brainspan.org) and PsychENCODE (www.psychencode.org). Consortia sought to generate and analyze multi-dimensional genomics data from the developing and adult human brain in healthy and disease states. One of the main goals has been to perform large-scale and integrated analysis of the genome, transcriptome, and epigenome of the human brain to broaden our understanding of human neurodevelopment. This dataset consists of sixteen regions, including eleven neocortical areas, of human donors of both sexes and various ethnic groups. In the first stage of this project, we provide the genome-wide exon-level transcriptome data generated using the Affymetrix GeneChip Human Exon 1.0 ST Arrays, and the genome-wide genotyping data for 2.5 million markers using the Illumina Human Omni 2.5-Quad Bead Chips. In the second stage of this project, we provide whole-genome sequencing data, transcriptome data by mRNA-Seq, small RNA data by smRNA-seq, DNA cytosine methylation by Infinium HumanMethylation450 BeadChip, and epigenomic/epigenetic data by ChIP-Seq for H3K4me3, H3K27me3, H3K27ac and CTCF.
Länk
Nyckelord
Versioner (1)
- 2022-12-06 2022-12-06 - Simon Heim
Rättsinnehavare
Nenad Sestan, MD, PhD, Yale University, New Haven, CT, USA
Uppladdad den
6 december 2022
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs000755 BrainSpan Atlas of the Human Brain
The subject sample mapping file includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes a mapping of sample IDs to other sample ID aliases, and the substudy (phs accession) that the sample belongs to and sample use technology. The substudies are: Spatiotemporal Transcriptome of the Human Brain and BrainSpan Atlas of the Developing and Adult Human Brain.
- StudyEvent: SEV1
- Eligibility Criteria
- This sample GEO mapping data table includes a mapping of study sample IDs to NCBI Gene Expression Omnibus (GEO) acccesions, type of GEO experiment, brain region, and left or right hemisphere.
- This sample attributes table includes body site where sample was collected and analyte type.
- The subject consent data table contains subject IDs, consent group information, and subject aliases.
- The subject sample mapping file includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes a mapping of sample IDs to other sample ID aliases, and the substudy (phs accession) that the sample belongs to and sample use technology. The substudies are: Spatiotemporal Transcriptome of the Human Brain and BrainSpan Atlas of the Developing and Adult Human Brain.
- The dataset provides age (post conception days), sex, and ethnicity information of subjects whose post mortem brains were sampled.
- This sample attributes table includes body site where sample was collected and analyte type.
Similar models
The subject sample mapping file includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes a mapping of sample IDs to other sample ID aliases, and the substudy (phs accession) that the sample belongs to and sample use technology. The substudies are: Spatiotemporal Transcriptome of the Human Brain and BrainSpan Atlas of the Developing and Adult Human Brain.
- StudyEvent: SEV1
- Eligibility Criteria
- This sample GEO mapping data table includes a mapping of study sample IDs to NCBI Gene Expression Omnibus (GEO) acccesions, type of GEO experiment, brain region, and left or right hemisphere.
- This sample attributes table includes body site where sample was collected and analyte type.
- The subject consent data table contains subject IDs, consent group information, and subject aliases.
- The subject sample mapping file includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes a mapping of sample IDs to other sample ID aliases, and the substudy (phs accession) that the sample belongs to and sample use technology. The substudies are: Spatiotemporal Transcriptome of the Human Brain and BrainSpan Atlas of the Developing and Adult Human Brain.
- The dataset provides age (post conception days), sex, and ethnicity information of subjects whose post mortem brains were sampled.
- This sample attributes table includes body site where sample was collected and analyte type.
C5420472 (UMLS CUI [1,2])