ID

45441

Descrizione

Principal Investigator: Bernice Porjesz*, PhD (*Administrative PI), SUNY Health Sciences Center, Brooklyn, NY, USA MeSH: Alcoholism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000763 COGA is a family study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US. COGA has gathered detailed, standardized data on study participants, including diagnostic and neurophysiological assessments. This sample has already proved successful in identifying several genes that influence the risk for alcoholism and neurophysiological endophenotypes, which have been independently replicated. COGA data were included as part of two Genetic Analysis Workshops, and the phenotypes are familiar to the genetics community. Alcoholic probands were recruited from treatment facilities, assessed by personal interview, and after securing permission, other family members were also assessed. A set of comparison families was drawn from the same communities as the families recruited through an alcoholic proband. Assessment involved a detailed personal interview developed for this project, the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), which gathers detailed information on alcoholism related symptoms along with other drugs and psychiatric symptoms. Many participants also came to the laboratories for electroencephalographic studies. Neurophysiological features that have been shown to be useful endophenotypes for which we have linkage and in some cases association results, are included for a subset of the case-control sample:- the beta power of the resting electroencephalogram (EEG), - the P3(00) amplitude of the visual event-related potential (ERP) and the - theta and delta event-related oscillations (EROs) underlying the P3. As part of COGA, a set of informative families was selected to have Genome-Wide Association data obtained within families. Genotyping was performed using the Illumina Human OmniExpress array 12.VI to genotype 2,282 subjects selected from 118 densely affected families. Genotyping was performed at the Genome Technology Access Center at Washington University School of Medicine in St. Louis. In addition, we also included genotypes for subjects (n=275 subjects) from these 118 families who were genotyped in a previous case-control GWAS using the Illumina 1M array. For quality control purposes, 51 of the 275 subjects were genotyped again on the Illumina Human OmniExpress array at the Washington University School of Medicine core facility.

collegamento

dbGaP study = phs000763

Keywords

versioni (1)
  1. 04/12/22 04/12/22 - Simon Heim
Titolare del copyright

Bernice Porjesz*, PhD (*Administrative PI), SUNY Health Sciences Center, Brooklyn, NY, USA

Caricato su

4 dicembre 2022

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
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dbGaP phs000763 The Collaborative Study on the Genetics of Alcoholism (COGA)

Inglese

Eligibility Criteria

6 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
Descrizione

COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0030705
UMLS CUI [1,2]
C0205487
UMLS CUI [1,3]
C1550330
UMLS CUI [1,4]
C0021562
UMLS CUI [1,5]
C0029921
UMLS CUI [1,6]
C0038580
UMLS CUI [1,7]
C0001962
UMLS CUI [1,8]
C0150543
UMLS CUI [1,9]
C0205197
A potential proband: must not have used intravenous drugs more than 30 times in a lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas.
Descrizione

A potential proband: must not have used intravenous drugs more than 30 times in a lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C3242635
UMLS CUI [1,2]
C1265611
UMLS CUI [1,3]
C4082120
UMLS CUI [1,4]
C1298908
UMLS CUI [1,5]
C1710032
UMLS CUI [1,6]
C1948053
UMLS CUI [1,7]
C3846017
UMLS CUI [1,8]
C0023890
UMLS CUI [1,9]
C0349464
UMLS CUI [1,10]
C0343752
UMLS CUI [1,11]
C0080103
UMLS CUI [1,12]
C0581906
UMLS CUI [1,13]
C0017446
Each COGA site recruited Control families consisting of two living parents and three or more full siblings, aged 14 or older. The Control Probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were to be representative of the general population and do not have to be unaffected individuals. Therefore, a Control family would not be eliminated if alcoholism is present among any of its members.
Descrizione

Each COGA site recruited Control families consisting of two living parents and three or more full siblings, aged 14 or older. The Control Probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were to be representative of the general population and do not have to be unaffected individuals. Therefore, a Control family would not be eliminated if alcoholism is present among any of its members.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0035172
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0015576
UMLS CUI [1,4]
C0449788
UMLS CUI [1,5]
C0030551
UMLS CUI [1,6]
C0037047
UMLS CUI [1,7]
C0150105
UMLS CUI [1,8]
C0018720
UMLS CUI [1,9]
C0011344
UMLS CUI [1,10]
C1882932
UMLS CUI [1,11]
C0683971
We extend families through all affecteds, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affecteds. If any of these relatives were affected, we extend to his/her first-degree relatives, and continue if any of them are affected. In addition, extension by leapfrogging over a living or dead unaffected into a branch containing at least two first-degree relatives of the "leapfrogee" who have 3 implications by history.
Descrizione

We extend families through all affecteds, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affecteds. If any of these relatives were affected, we extend to his/her first-degree relatives, and continue if any of them are affected. In addition, extension by leapfrogging over a living or dead unaffected into a branch containing at least two first-degree relatives of the "leapfrogee" who have 3 implications by history.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0444502
UMLS CUI [1,2]
C0080103
UMLS CUI [1,3]
C1521801
UMLS CUI [1,4]
C2348563
UMLS CUI [1,5]
C0231448
UMLS CUI [1,6]
C0522476
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Similar models

Eligibility Criteria

6 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
Item
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
boolean
C0030705 (UMLS CUI [1,1])
C0205487 (UMLS CUI [1,2])
C1550330 (UMLS CUI [1,3])
C0021562 (UMLS CUI [1,4])
C0029921 (UMLS CUI [1,5])
C0038580 (UMLS CUI [1,6])
C0001962 (UMLS CUI [1,7])
C0150543 (UMLS CUI [1,8])
C0205197 (UMLS CUI [1,9])
A potential proband: must not have used intravenous drugs more than 30 times in a lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas.
Item
A potential proband: must not have used intravenous drugs more than 30 times in a lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas.
boolean
C3242635 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C4082120 (UMLS CUI [1,3])
C1298908 (UMLS CUI [1,4])
C1710032 (UMLS CUI [1,5])
C1948053 (UMLS CUI [1,6])
C3846017 (UMLS CUI [1,7])
C0023890 (UMLS CUI [1,8])
C0349464 (UMLS CUI [1,9])
C0343752 (UMLS CUI [1,10])
C0080103 (UMLS CUI [1,11])
C0581906 (UMLS CUI [1,12])
C0017446 (UMLS CUI [1,13])
Each COGA site recruited Control families consisting of two living parents and three or more full siblings, aged 14 or older. The Control Probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were to be representative of the general population and do not have to be unaffected individuals. Therefore, a Control family would not be eliminated if alcoholism is present among any of its members.
Item
Each COGA site recruited Control families consisting of two living parents and three or more full siblings, aged 14 or older. The Control Probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were to be representative of the general population and do not have to be unaffected individuals. Therefore, a Control family would not be eliminated if alcoholism is present among any of its members.
boolean
C0035172 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0015576 (UMLS CUI [1,3])
C0449788 (UMLS CUI [1,4])
C0030551 (UMLS CUI [1,5])
C0037047 (UMLS CUI [1,6])
C0150105 (UMLS CUI [1,7])
C0018720 (UMLS CUI [1,8])
C0011344 (UMLS CUI [1,9])
C1882932 (UMLS CUI [1,10])
C0683971 (UMLS CUI [1,11])
We extend families through all affecteds, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affecteds. If any of these relatives were affected, we extend to his/her first-degree relatives, and continue if any of them are affected. In addition, extension by leapfrogging over a living or dead unaffected into a branch containing at least two first-degree relatives of the "leapfrogee" who have 3 implications by history.
Item
We extend families through all affecteds, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affecteds. If any of these relatives were affected, we extend to his/her first-degree relatives, and continue if any of them are affected. In addition, extension by leapfrogging over a living or dead unaffected into a branch containing at least two first-degree relatives of the "leapfrogee" who have 3 implications by history.
boolean
C0444502 (UMLS CUI [1,1])
C0080103 (UMLS CUI [1,2])
C1521801 (UMLS CUI [1,3])
C2348563 (UMLS CUI [1,4])
C0231448 (UMLS CUI [1,5])
C0522476 (UMLS CUI [1,6])
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