ID
45436
Beskrivning
Principal Investigator: Richard Wilson, Washington University School of Medicine, MO, USA MeSH: Breast Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000611 Early passage breast cancer xenografts have been proposed as alternatives to cell lines as model systems for studying the basic biology of tumors and for advancing therapy development. This study explores the relatedness of primary disease genomes to their matched xenotransplants. Using paired-end massively parallel sequencing 17 matched progenitor tumor, xenograft and normal trios were sequenced to at least 30-fold coverage with diploid coverage of at least 95% of the genome as determined by SNP array concordance. RNA sequence was generated from the xenograft tumors. The xenografts were derived from a spectrum of tumor samples from patients with both early and advanced breast cancer.
Länk
Nyckelord
Versioner (1)
- 2022-11-29 2022-11-29 - Simon Heim
Rättsinnehavare
Richard Wilson, Washington University School of Medicine, MO, USA
Uppladdad den
29 november 2022
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs000611 Whole Genome Comparisons of Breast Cancers and their Xenotransplants
Subject ID, consent group, subject source, subject source ID, and affection status of participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- StudyEvent: SEV1
- Subject ID, consent group, subject source, subject source ID, and affection status of participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- Subject ID, sample ID, sample source, sample source ID, and sample use variable obtained from participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- Subject ID, race, gender, ER and HER2 receptor status, metastatic sites, treatment history, post-diagnosis survival, and medical history of relatives [breast or ovarian cancer] of participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- Sample ID, ER/HER2 status of tumor, body site where human tumor was obtained and used for both DNA sequencing and xenotransplant, analyte type, and tumor status of sample obtained from participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
Similar models
Subject ID, consent group, subject source, subject source ID, and affection status of participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- StudyEvent: SEV1
- Subject ID, consent group, subject source, subject source ID, and affection status of participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- Subject ID, sample ID, sample source, sample source ID, and sample use variable obtained from participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- Subject ID, race, gender, ER and HER2 receptor status, metastatic sites, treatment history, post-diagnosis survival, and medical history of relatives [breast or ovarian cancer] of participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
- Sample ID, ER/HER2 status of tumor, body site where human tumor was obtained and used for both DNA sequencing and xenotransplant, analyte type, and tumor status of sample obtained from participants with breast cancer and involved in the "Whole Genome Comparisons of Breast Cancers and their Xenotransplants" project.
C2348585 (UMLS CUI [1,2])
C1257890 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C0681850 (UMLS CUI [1,3])
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])