ID

45419

Beschrijving

Principal Investigator: MeSH: Uterine Cervical Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000640 This study contains all authorized whole genome sequence data of the HeLa cell line from datasets currently in dbGaP. These data have been approved for health, medical, and/or biomedical research purposes. Access to these data can be granted for one year. Accessible data will include the studies listed on this page and any additional authorized datasets that become available during this one-year period. The HeLa Genome Data Access Working Group of the Advisory Committee to the Director (ACD) will review requests from the research community for access to these datasets and assess whether the requests align with the terms of use defined in the HeLa Genome Data Use Agreement. The Working Group's findings will be reported to the ACD, and the ACD will make recommendations to the NIH Director about whether a request should be approved or disapproved. The NIH Director will decide whether access to the data will be granted.

Link

dbGaP-study=phs000640

Trefwoorden

  1. 25-11-22 25-11-22 - Chiara Middel
Houder van rechten

The genome sequence described/used in this research was derived from a HeLa cell line. Henrietta Lacks, and the HeLa cell line that was established from her tumor cells without her knowledge or consent in 1951, have made significant contributions to scientific progress and advances in human health. We are grateful to Henrietta Lacks, now deceased, and to her surviving family members for their contributions to biomedical research. The request to use HeLa data for this research was approved by the NIH Director based on the recommendations of the Advisory Committee to the Director and the evaluation by its HeLa Genome Data Access Working Group (http://acd.od.nih.gov/hlgda.htm). The genomic datasets used for analysis described in this manuscript were obtained from the database of Genotypes and Phenotypes (dbGaP) through dbGaP accession number phs000640.

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25 november 2022

DOI

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Creative Commons BY 4.0

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dbGaP phs000640 HeLa Cell Genome Sequencing Studies

Subject ID, subject source, source subject ID, consent group, and affection status of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.

  1. StudyEvent: SEV1
    1. Subject ID, subject source, source subject ID, consent group, and affection status of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
    2. Subject ID, sample ID, sample source, source sample ID, study, and sample use variable of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
    3. Sample ID, analyte type, and tumor status of a participant with uterine cervical neoplasm and involved in the "The Haplotype-Resolved Genome and Epigenome of the Aneuploid HeLa Cancer Cell Line" project.
    4. Sample ID, analyte type, and tumor status of sample obtained from a participant with uterine cervical neoplasm and involved in the "The Genomic and Transcriptomic Landscape of a HeLa Cell Line" project.
    5. Subject ID, birthplace, sex, and race of a participant with uterine cervical neoplasms and involved in the "HeLa S3 (CCL-2.2) HiC Sequencing" project.
    6. Sample ID and trace ID of a participant with uterine cervical neoplasms and involved in the "HeLa S3 (CCL-2.2) HiC Sequencing" project.
    7. Sample ID, body site where sample was collected, analyte type, histological type and sequences center of a participant with uterine cervical neoplasms and involved in the "HeLa S3 (CCL-2.2) HiC Sequencing" project.
    8. Sample ID, body site where sample was obtained, analyte type, tumor status, histological type of sample, primary or metastatic tumor, sequencing center of participant with uterine cervical adenocarcinoma and involved in the "High Resolution Maps of the HeLa 3D Genome Using Hi-C" project.
    9. Sample ID, body site where sample was obtained, analyte type, tumor status of sample, histological type of sample, primary or metastatic tumor, primary tumor location, and sequencing center of participant with uterine cervical adenocarcinoma and involved in the "The Heterogeneity Study of HeLa S3 Cells Based on Full-Length Single-Cell RNA-seq" project.
    10. Sample ID, analyte type, body site where sample was obtained, genotyping center, and tumor status of sample obtained from a participant with uterine cervical neoplasm and involved in the "Construction of Thousands of Single Cell Genome Sequencing Libraries Using Combinatorial Indexing" project.
    11. Sample ID, analyte type, body site where sample was obtained, genotyping center, and tumor status of sample obtained from a participant with uterine cervical neoplasm and involved in the "Massively Multiplex Single-Cell Hi-C of HeLa Cells" project.
    12. Sample ID, analyte type, body site where sample was obtained, histological type of sample, and tumor status of participants uterine cervical neoplasm and involved in the "Identification of G-quadruplex Clusters by High-throughput Sequencing of Whole-genome Amplified Products with a G-quadruplex Ligand" project.
    13. Sample ID and GEO accession of participants with or without gastrointestinal cancer and involved in the "Gastrointestinal Cancer Treatment Responders" project.
    14. Sample ID, analyte type, body site where sample was obtained, tumor status of sample, and sequencing center of participants with or without gastrointestinal cancer and involved in the "Gastrointestinal Cancer Treatment Responders" project.
    15. Sample ID, experimental conditions, tumor sample status, type of sample data, and source where sample was sequenced of a participant with uterine cervical neoplasm and involved in the "Examination of engineered LINE-1 Integration events in HeLa cells" project.
    16. Sample ID, analyte type, body site where sample was obtained, histological type of sample, and tumor status of sample of a participant with uterine cervical neoplasm and involved in the "RNA Ligation Precedes U6 snRNA/LINE-1 Retrotransposition" project.
    17. Sample ID, analyte type, body site where sample was obtained, histological type of sample, tumor status of sample, primary or metastatic tumor, primary tumor location, and sequencing center of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
    18. Sample ID, tumor status of sample, and histological type of sample obtained from a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
pht003438
Beschrijving

pht003438

Alias
UMLS CUI [1,1]
C3846158
Data use consent
Beschrijving

CONSENT

Datatype

text

Alias
UMLS CUI [1,1]
C0021430
Subject source
Beschrijving

SUBJECT_SOURCE

Datatype

text

Alias
UMLS CUI [1,1]
C0449416
Source subject ID
Beschrijving

SOURCE_SUBJECT_ID

Datatype

text

Alias
UMLS CUI [1,1]
C2348585
UMLS CUI [1,2]
C0449416
Affection status
Beschrijving

AFFECTION_STATUS

Datatype

text

Alias
UMLS CUI [1,1]
C3274646
Subject ID
Beschrijving

SUBJECT_ID

Datatype

text

Alias
UMLS CUI [1,1]
C2348585

Similar models

Subject ID, subject source, source subject ID, consent group, and affection status of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.

  1. StudyEvent: SEV1
    1. Subject ID, subject source, source subject ID, consent group, and affection status of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
    2. Subject ID, sample ID, sample source, source sample ID, study, and sample use variable of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
    3. Sample ID, analyte type, and tumor status of a participant with uterine cervical neoplasm and involved in the "The Haplotype-Resolved Genome and Epigenome of the Aneuploid HeLa Cancer Cell Line" project.
    4. Sample ID, analyte type, and tumor status of sample obtained from a participant with uterine cervical neoplasm and involved in the "The Genomic and Transcriptomic Landscape of a HeLa Cell Line" project.
    5. Subject ID, birthplace, sex, and race of a participant with uterine cervical neoplasms and involved in the "HeLa S3 (CCL-2.2) HiC Sequencing" project.
    6. Sample ID and trace ID of a participant with uterine cervical neoplasms and involved in the "HeLa S3 (CCL-2.2) HiC Sequencing" project.
    7. Sample ID, body site where sample was collected, analyte type, histological type and sequences center of a participant with uterine cervical neoplasms and involved in the "HeLa S3 (CCL-2.2) HiC Sequencing" project.
    8. Sample ID, body site where sample was obtained, analyte type, tumor status, histological type of sample, primary or metastatic tumor, sequencing center of participant with uterine cervical adenocarcinoma and involved in the "High Resolution Maps of the HeLa 3D Genome Using Hi-C" project.
    9. Sample ID, body site where sample was obtained, analyte type, tumor status of sample, histological type of sample, primary or metastatic tumor, primary tumor location, and sequencing center of participant with uterine cervical adenocarcinoma and involved in the "The Heterogeneity Study of HeLa S3 Cells Based on Full-Length Single-Cell RNA-seq" project.
    10. Sample ID, analyte type, body site where sample was obtained, genotyping center, and tumor status of sample obtained from a participant with uterine cervical neoplasm and involved in the "Construction of Thousands of Single Cell Genome Sequencing Libraries Using Combinatorial Indexing" project.
    11. Sample ID, analyte type, body site where sample was obtained, genotyping center, and tumor status of sample obtained from a participant with uterine cervical neoplasm and involved in the "Massively Multiplex Single-Cell Hi-C of HeLa Cells" project.
    12. Sample ID, analyte type, body site where sample was obtained, histological type of sample, and tumor status of participants uterine cervical neoplasm and involved in the "Identification of G-quadruplex Clusters by High-throughput Sequencing of Whole-genome Amplified Products with a G-quadruplex Ligand" project.
    13. Sample ID and GEO accession of participants with or without gastrointestinal cancer and involved in the "Gastrointestinal Cancer Treatment Responders" project.
    14. Sample ID, analyte type, body site where sample was obtained, tumor status of sample, and sequencing center of participants with or without gastrointestinal cancer and involved in the "Gastrointestinal Cancer Treatment Responders" project.
    15. Sample ID, experimental conditions, tumor sample status, type of sample data, and source where sample was sequenced of a participant with uterine cervical neoplasm and involved in the "Examination of engineered LINE-1 Integration events in HeLa cells" project.
    16. Sample ID, analyte type, body site where sample was obtained, histological type of sample, and tumor status of sample of a participant with uterine cervical neoplasm and involved in the "RNA Ligation Precedes U6 snRNA/LINE-1 Retrotransposition" project.
    17. Sample ID, analyte type, body site where sample was obtained, histological type of sample, tumor status of sample, primary or metastatic tumor, primary tumor location, and sequencing center of a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
    18. Sample ID, tumor status of sample, and histological type of sample obtained from a participant with uterine cervical neoplasm and involved in the "HeLa Cell Genome Sequencing Studies" project.
Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Item Group
pht003438
C3846158 (UMLS CUI [1,1])
Item
Data use consent
text
C0021430 (UMLS CUI [1,1])
Code List
Data use consent
CL Item
Health/Medical/Biomedical (HMB) (1)
SUBJECT_SOURCE
Item
Subject source
text
C0449416 (UMLS CUI [1,1])
SOURCE_SUBJECT_ID
Item
Source subject ID
text
C2348585 (UMLS CUI [1,1])
C0449416 (UMLS CUI [1,2])
Item
Affection status
text
C3274646 (UMLS CUI [1,1])
Code List
Affection status
CL Item
Case (1)
C3274647 (UMLS CUI [1,1])
SUBJECT_ID
Item
Subject ID
text
C2348585 (UMLS CUI [1,1])

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