ID

45414

Description

Principal Investigator: Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA MeSH: Respiration Disorders,Sepsis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000631 Acute Respiratory Distress Syndrome (ARDS)/ Acute Lung Injury (ALI) is a syndrome defined by the presence of acute hypoxemic respiratory failure, bilateral pulmonary infiltrates on chest radiograph, a known clinical risk factor (e.g. sepsis, pneumonia, trauma, gastric fluid aspiration, pancreatitis, massive transfusion), and the absence of physiologic or clinical evidence of congestive heart failure. The Identification of SNPs Predisposing to Altered ALI Risk (iSPAAR) study is a multi-institutional cooperative study, funded through the NHLBI Recovery Act, that assembled samples and phenotype information from existing cohorts. The consortium included samples from patients with ARDS from the NIH NHLBI ARDS Clinical Trials Network (ARDSNet). Samples were obtained from 3 interventional treatment trials in patients with ARDS, including the Fluid and Catheter Treatment Trial (FACTT), the Albuterol to Treat Acute Lung Injury (ALTA) trial, and the Omega-3 Fatty Acid/Antioxidant Supplementation for ALI trial (Omega). In addition to ARDSnet samples, samples from the other cohorts included cases of established ARDS but also controls: critically ill patients who were at-risk for ARDS but who did not develop ARDS during their hospital course. These cohorts included the Molecular Epidemiology of Acute Respiratory Distress (MEA) Study enrolled at the Harvard University/Massachusetts General Hospital, the Systemic Inflammatory Immune Response Syndrome (SIRS) Patient Database and ICU Traumatic Injury cohorts from Harborview Medical Center, and cohorts collected from the ALI research programs at the University of Pennsylvania and the University of California, San Francisco. *The Cohort is utilized in the following dbGaP sub-studies.* To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page phs000631 ARDSnet iSPAAR Consortium.- phs000334 ESP_LungGO_ALI - phs000686 ALI_GeneticRisk

Link

dbGaP study = phs000631

Keywords

Versions (1)
  1. 11/23/22 11/23/22 - Simon Heim
Copyright Holder

Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA

Uploaded on

November 23, 2022

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000631 ARDSnet and the iSPAAR Consortium: Genetic Studies

English

Eligibility Criteria

6 forms  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    3. Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    4. Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    5. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    6. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
Inclusions:
Description

Inclusions:

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
Caucasian
Description

Caucasian

Data type

boolean

Alias
UMLS CUI [1,1]
C0043157
Controls: patients at-risk for development of ARDS based on the presence of an ARDS risk factor (e.g., sepsis, pneumonia, trauma, aspiration, pancreatitis, massive transfusion) but who did not develop ARDS during their hospital course.
Description

Controls: patients at-risk for development of ARDS based on the presence of an ARDS risk factor (e.g., sepsis, pneumonia, trauma, aspiration, pancreatitis, massive transfusion) but who did not develop ARDS during their hospital course.

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
UMLS CUI [1,2]
C1444641
UMLS CUI [1,3]
C2887484
UMLS CUI [1,4]
C0035648
UMLS CUI [1,5]
C0243026
UMLS CUI [1,6]
C0030305
UMLS CUI [1,7]
C0349707
UMLS CUI [1,8]
C0032285
UMLS CUI [1,9]
C3714660
UMLS CUI [1,10]
C0456675
UMLS CUI [2,1]
C0009932
UMLS CUI [2,2]
C2887484
UMLS CUI [2,3]
C4534490
Cases: patients with ARDS as defined by: 1) acute onset with P/F <300, 2) bilateral chest infiltrates on chest radiograph, 3) absence of clinical evidence for left atrial hypertension, and 4) use of invasive positive pressure mechanical ventilation.
Description

Cases: patients with ARDS as defined by: 1) acute onset with P/F <300, 2) bilateral chest infiltrates on chest radiograph, 3) absence of clinical evidence for left atrial hypertension, and 4) use of invasive positive pressure mechanical ventilation.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C2887484
UMLS CUI [1,3]
C1276802
UMLS CUI [1,4]
C1698575
UMLS CUI [1,5]
C3842377
UMLS CUI [1,6]
C2939072
UMLS CUI [1,7]
C0332125
UMLS CUI [1,8]
C0238705
UMLS CUI [1,9]
C2349751
Exclusions:
Description

Exclusions:

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
Metastatic cancer
Description

Metastatic cancer

Data type

boolean

Alias
UMLS CUI [1,1]
C0027627
Hemodialysis dependence
Description

Hemodialysis dependence

Data type

boolean

Alias
UMLS CUI [1,1]
C2939452
Hepatic failure
Description

Hepatic failure

Data type

boolean

Alias
UMLS CUI [1,1]
C0085605
Immunosuppression
Description

Immunosuppression

Data type

boolean

Alias
UMLS CUI [1,1]
C4048329
Burns
Description

Burns

Data type

boolean

Alias
UMLS CUI [1,1]
C0006434
Pregnancy
Description

Pregnancy

Data type

boolean

Alias
UMLS CUI [1,1]
C0032961
Clinical evidence of elevated left atrial pressures
Description

Clinical evidence of elevated left atrial pressures

Data type

boolean

Alias
UMLS CUI [1,1]
C5554846
UMLS CUI [1,2]
C4531219
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Similar models

Eligibility Criteria

6 forms
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    3. Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    4. Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    5. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    6. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Inclusions:
Item
Inclusions:
boolean
C1512693 (UMLS CUI [1,1])
Caucasian
Item
Caucasian
boolean
C0043157 (UMLS CUI [1,1])
Controls: patients at-risk for development of ARDS based on the presence of an ARDS risk factor (e.g., sepsis, pneumonia, trauma, aspiration, pancreatitis, massive transfusion) but who did not develop ARDS during their hospital course.
Item
Controls: patients at-risk for development of ARDS based on the presence of an ARDS risk factor (e.g., sepsis, pneumonia, trauma, aspiration, pancreatitis, massive transfusion) but who did not develop ARDS during their hospital course.
boolean
C0009932 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C2887484 (UMLS CUI [1,3])
C0035648 (UMLS CUI [1,4])
C0243026 (UMLS CUI [1,5])
C0030305 (UMLS CUI [1,6])
C0349707 (UMLS CUI [1,7])
C0032285 (UMLS CUI [1,8])
C3714660 (UMLS CUI [1,9])
C0456675 (UMLS CUI [1,10])
C0009932 (UMLS CUI [2,1])
C2887484 (UMLS CUI [2,2])
C4534490 (UMLS CUI [2,3])
Cases: patients with ARDS as defined by: 1) acute onset with P/F <300, 2) bilateral chest infiltrates on chest radiograph, 3) absence of clinical evidence for left atrial hypertension, and 4) use of invasive positive pressure mechanical ventilation.
Item
Cases: patients with ARDS as defined by: 1) acute onset with P/F <300, 2) bilateral chest infiltrates on chest radiograph, 3) absence of clinical evidence for left atrial hypertension, and 4) use of invasive positive pressure mechanical ventilation.
boolean
C1706256 (UMLS CUI [1,1])
C2887484 (UMLS CUI [1,2])
C1276802 (UMLS CUI [1,3])
C1698575 (UMLS CUI [1,4])
C3842377 (UMLS CUI [1,5])
C2939072 (UMLS CUI [1,6])
C0332125 (UMLS CUI [1,7])
C0238705 (UMLS CUI [1,8])
C2349751 (UMLS CUI [1,9])
Exclusions:
Item
Exclusions:
boolean
C0680251 (UMLS CUI [1,1])
Metastatic cancer
Item
Metastatic cancer
boolean
C0027627 (UMLS CUI [1,1])
Hemodialysis dependence
Item
Hemodialysis dependence
boolean
C2939452 (UMLS CUI [1,1])
Hepatic failure
Item
Hepatic failure
boolean
C0085605 (UMLS CUI [1,1])
Immunosuppression
Item
Immunosuppression
boolean
C4048329 (UMLS CUI [1,1])
Burns
Item
Burns
boolean
C0006434 (UMLS CUI [1,1])
Pregnancy
Item
Pregnancy
boolean
C0032961 (UMLS CUI [1,1])
Clinical evidence of elevated left atrial pressures
Item
Clinical evidence of elevated left atrial pressures
boolean
C5554846 (UMLS CUI [1,1])
C4531219 (UMLS CUI [1,2])
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