ID

45414

Description

Principal Investigator: Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA MeSH: Respiration Disorders,Sepsis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000631 Acute Respiratory Distress Syndrome (ARDS)/ Acute Lung Injury (ALI) is a syndrome defined by the presence of acute hypoxemic respiratory failure, bilateral pulmonary infiltrates on chest radiograph, a known clinical risk factor (e.g. sepsis, pneumonia, trauma, gastric fluid aspiration, pancreatitis, massive transfusion), and the absence of physiologic or clinical evidence of congestive heart failure. The Identification of SNPs Predisposing to Altered ALI Risk (iSPAAR) study is a multi-institutional cooperative study, funded through the NHLBI Recovery Act, that assembled samples and phenotype information from existing cohorts. The consortium included samples from patients with ARDS from the NIH NHLBI ARDS Clinical Trials Network (ARDSNet). Samples were obtained from 3 interventional treatment trials in patients with ARDS, including the Fluid and Catheter Treatment Trial (FACTT), the Albuterol to Treat Acute Lung Injury (ALTA) trial, and the Omega-3 Fatty Acid/Antioxidant Supplementation for ALI trial (Omega). In addition to ARDSnet samples, samples from the other cohorts included cases of established ARDS but also controls: critically ill patients who were at-risk for ARDS but who did not develop ARDS during their hospital course. These cohorts included the Molecular Epidemiology of Acute Respiratory Distress (MEA) Study enrolled at the Harvard University/Massachusetts General Hospital, the Systemic Inflammatory Immune Response Syndrome (SIRS) Patient Database and ICU Traumatic Injury cohorts from Harborview Medical Center, and cohorts collected from the ALI research programs at the University of Pennsylvania and the University of California, San Francisco. *The Cohort is utilized in the following dbGaP sub-studies.* To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page phs000631 ARDSnet iSPAAR Consortium.- phs000334 ESP_LungGO_ALI - phs000686 ALI_GeneticRisk

Link

dbGaP study = phs000631

Keywords

Versions (1)
  1. 11/23/22 11/23/22 - Simon Heim
Copyright Holder

Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA

Uploaded on

November 23, 2022

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000631 ARDSnet and the iSPAAR Consortium: Genetic Studies

English

Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.

6 forms  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    3. Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    4. Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    5. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    6. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
pht003602
Description

pht003602

Alias
UMLS CUI [1,1]
C3846158
De-identified sample ID
Description

sample_id

Data type

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C1299222
Body site where sample was collected
Description

body_site

Data type

string

Alias
UMLS CUI [1,1]
C0449705
Analyte type
Description

analyte_type

Data type

string

Alias
UMLS CUI [1,1]
C4744818
Tumor status
Description

is_tumor

Data type

text

Alias
UMLS CUI [1,1]
C0475752
Cell or tissue type or subtype of sample
Description

histological_type

Data type

string

Alias
UMLS CUI [1,1]
C2347026
UMLS CUI [1,2]
C0007634
UMLS CUI [1,3]
C0332307
UMLS CUI [2,1]
C2347026
UMLS CUI [2,2]
C0007634
UMLS CUI [2,3]
C0449560
UMLS CUI [3,1]
C1292533
UMLS CUI [3,2]
C0332307
UMLS CUI [4,1]
C1292533
UMLS CUI [4,2]
C0449560
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Similar models

Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.

6 forms
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    3. Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    4. Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    5. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    6. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
pht003602
C3846158 (UMLS CUI [1,1])
sample_id
Item
De-identified sample ID
string
C4684638 (UMLS CUI [1,1])
C1299222 (UMLS CUI [1,2])
body_site
Item
Body site where sample was collected
string
C0449705 (UMLS CUI [1,1])
analyte_type
Item
Analyte type
string
C4744818 (UMLS CUI [1,1])
Item
Tumor status
text
C0475752 (UMLS CUI [1,1])
is_tumor
Code List
Tumor status
CL Item
Is not a tumor (n)
histological_type
Item
Cell or tissue type or subtype of sample
string
C2347026 (UMLS CUI [1,1])
C0007634 (UMLS CUI [1,2])
C0332307 (UMLS CUI [1,3])
C2347026 (UMLS CUI [2,1])
C0007634 (UMLS CUI [2,2])
C0449560 (UMLS CUI [2,3])
C1292533 (UMLS CUI [3,1])
C0332307 (UMLS CUI [3,2])
C1292533 (UMLS CUI [4,1])
C0449560 (UMLS CUI [4,2])
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