0 Evaluaciones
ID

45414

Descripción

Principal Investigator: Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA MeSH: Respiration Disorders,Sepsis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000631 Acute Respiratory Distress Syndrome (ARDS)/ Acute Lung Injury (ALI) is a syndrome defined by the presence of acute hypoxemic respiratory failure, bilateral pulmonary infiltrates on chest radiograph, a known clinical risk factor (e.g. sepsis, pneumonia, trauma, gastric fluid aspiration, pancreatitis, massive transfusion), and the absence of physiologic or clinical evidence of congestive heart failure. The Identification of SNPs Predisposing to Altered ALI Risk (iSPAAR) study is a multi-institutional cooperative study, funded through the NHLBI Recovery Act, that assembled samples and phenotype information from existing cohorts. The consortium included samples from patients with ARDS from the NIH NHLBI ARDS Clinical Trials Network (ARDSNet). Samples were obtained from 3 interventional treatment trials in patients with ARDS, including the Fluid and Catheter Treatment Trial (FACTT), the Albuterol to Treat Acute Lung Injury (ALTA) trial, and the Omega-3 Fatty Acid/Antioxidant Supplementation for ALI trial (Omega). In addition to ARDSnet samples, samples from the other cohorts included cases of established ARDS but also controls: critically ill patients who were at-risk for ARDS but who did not develop ARDS during their hospital course. These cohorts included the Molecular Epidemiology of Acute Respiratory Distress (MEA) Study enrolled at the Harvard University/Massachusetts General Hospital, the Systemic Inflammatory Immune Response Syndrome (SIRS) Patient Database and ICU Traumatic Injury cohorts from Harborview Medical Center, and cohorts collected from the ALI research programs at the University of Pennsylvania and the University of California, San Francisco. *The Cohort is utilized in the following dbGaP sub-studies.* To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page phs000631 ARDSnet iSPAAR Consortium.- phs000334 ESP_LungGO_ALI - phs000686 ALI_GeneticRisk

Link

dbGaP study = phs000631

Palabras clave

Versiones (1)
  1. 23/11/22 23/11/22 - Simon Heim
Titular de derechos de autor

Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA

Subido en

23 de noviembre de 2022

DOI

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Licencia

Creative Commons BY 4.0
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    dbGaP phs000631 ARDSnet and the iSPAAR Consortium: Genetic Studies

    Inglés

    Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.

    6 formularios  
    1. StudyEvent: SEV1
      1. Eligibility Criteria
      2. Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      3. Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      4. Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      5. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      6. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    pht003602
    Descripción

    pht003602

    Alias
    UMLS CUI [1,1]
    C3846158
    De-identified sample ID
    Descripción

    sample_id

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C1299222
    Body site where sample was collected
    Descripción

    body_site

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0449705
    Analyte type
    Descripción

    analyte_type

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C4744818
    Tumor status
    Descripción

    is_tumor

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C0475752
    Cell or tissue type or subtype of sample
    Descripción

    histological_type

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C2347026
    UMLS CUI [1,2]
    C0007634
    UMLS CUI [1,3]
    C0332307
    UMLS CUI [2,1]
    C2347026
    UMLS CUI [2,2]
    C0007634
    UMLS CUI [2,3]
    C0449560
    UMLS CUI [3,1]
    C1292533
    UMLS CUI [3,2]
    C0332307
    UMLS CUI [4,1]
    C1292533
    UMLS CUI [4,2]
    C0449560
    Volver a la parte superior de la página

    Similar models

    Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.

    6 formularios
    1. StudyEvent: SEV1
      1. Eligibility Criteria
      2. Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      3. Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      4. Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      5. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
      6. Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
    Name
    Tipo
    Description | Question | Decode (Coded Value)
    Tipo de datos
    Alias
    Item Group
    pht003602
    C3846158 (UMLS CUI [1,1])
    sample_id
    Item
    De-identified sample ID
    string
    C4684638 (UMLS CUI [1,1])
    C1299222 (UMLS CUI [1,2])
    body_site
    Item
    Body site where sample was collected
    string
    C0449705 (UMLS CUI [1,1])
    analyte_type
    Item
    Analyte type
    string
    C4744818 (UMLS CUI [1,1])
    Item
    Tumor status
    text
    C0475752 (UMLS CUI [1,1])
    is_tumor
    Code List
    Tumor status
    CL Item
    Is not a tumor (n)
    histological_type
    Item
    Cell or tissue type or subtype of sample
    string
    C2347026 (UMLS CUI [1,1])
    C0007634 (UMLS CUI [1,2])
    C0332307 (UMLS CUI [1,3])
    C2347026 (UMLS CUI [2,1])
    C0007634 (UMLS CUI [2,2])
    C0449560 (UMLS CUI [2,3])
    C1292533 (UMLS CUI [3,1])
    C0332307 (UMLS CUI [3,2])
    C1292533 (UMLS CUI [4,1])
    C0449560 (UMLS CUI [4,2])
    Volver a la parte superior de la página 

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