ID
45414
Description
Principal Investigator: Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA MeSH: Respiration Disorders,Sepsis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000631 Acute Respiratory Distress Syndrome (ARDS)/ Acute Lung Injury (ALI) is a syndrome defined by the presence of acute hypoxemic respiratory failure, bilateral pulmonary infiltrates on chest radiograph, a known clinical risk factor (e.g. sepsis, pneumonia, trauma, gastric fluid aspiration, pancreatitis, massive transfusion), and the absence of physiologic or clinical evidence of congestive heart failure. The Identification of SNPs Predisposing to Altered ALI Risk (iSPAAR) study is a multi-institutional cooperative study, funded through the NHLBI Recovery Act, that assembled samples and phenotype information from existing cohorts. The consortium included samples from patients with ARDS from the NIH NHLBI ARDS Clinical Trials Network (ARDSNet). Samples were obtained from 3 interventional treatment trials in patients with ARDS, including the Fluid and Catheter Treatment Trial (FACTT), the Albuterol to Treat Acute Lung Injury (ALTA) trial, and the Omega-3 Fatty Acid/Antioxidant Supplementation for ALI trial (Omega). In addition to ARDSnet samples, samples from the other cohorts included cases of established ARDS but also controls: critically ill patients who were at-risk for ARDS but who did not develop ARDS during their hospital course. These cohorts included the Molecular Epidemiology of Acute Respiratory Distress (MEA) Study enrolled at the Harvard University/Massachusetts General Hospital, the Systemic Inflammatory Immune Response Syndrome (SIRS) Patient Database and ICU Traumatic Injury cohorts from Harborview Medical Center, and cohorts collected from the ALI research programs at the University of Pennsylvania and the University of California, San Francisco. *The Cohort is utilized in the following dbGaP sub-studies.* To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page phs000631 ARDSnet iSPAAR Consortium.- phs000334 ESP_LungGO_ALI - phs000686 ALI_GeneticRisk
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Keywords
Versions (1)
- 11/23/22 11/23/22 - Simon Heim
Copyright Holder
Mark M. Wurfel, MD, PhD, University of Washington, Seattle, WA, USA
Uploaded on
November 23, 2022
DOI
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License
Creative Commons BY 4.0
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dbGaP phs000631 ARDSnet and the iSPAAR Consortium: Genetic Studies
Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
Similar models
Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Subject ID, sample ID, study ID, and sample use variable obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Subject ID, primary phenotype status, day when subject died in hospital, age, sex, race, primary risk factors associated with participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of samples obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
- Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without acute respiratory distress syndrome and involved in the "ARDSnet and the iSPAAR Consortium: Genomic Basis of Susceptibility and Outcomes in Patients with the Acute Respiratory Distress Syndrome (ARDS)" project.
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