ID
45399
Descrição
Principal Investigator: John Allman, PhD, California Institute of Technology, Pasadena, CA, USA MeSH: Autism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000609 RNA-Seq studies of Gene Expression in Cells and Networks in FI (fronto-insular) and AC (anterior cingulate) cortex in Autism. We seek to understand the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well described autism versus age and sex matched neurotypical individuals. We have investigated two specific cortical areas involved in self-awareness and social reciprocity which are abnormal in autism and have found increased expression in a network of genes related to inflammation in autism group A, whereas the remaining cases, autism group B, have increased expression in a network of genes related to synapses. The current dbGaP study release includes RNA sequencing and phenotype data of n=27 subjects of African - American, Caucasian, or Hispanic origin.
Link
Palavras-chave
Versões (1)
- 15/11/2022 15/11/2022 - Simon Heim
Titular dos direitos
John Allman, PhD, California Institute of Technology, Pasadena, CA, USA
Transferido a
15 de novembro de 2022
DOI
Para um pedido faça login.
Licença
Creative Commons BY 4.0
Comentários do modelo :
Aqui pode comentar o modelo. Pode comentá-lo especificamente através dos balões de texto nos grupos de itens e itens.
Comentários do grupo de itens para :
Comentários do item para :
Para descarregar formulários, precisa de ter uma sessão iniciada. Por favor faça login ou registe-se gratuitamente.
dbGaP phs000609 RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
Subject - Consent - Affection Status Information
Similar models
Subject - Consent - Affection Status Information
C1257890 (UMLS CUI [1,2])
C0242481 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])