ID
45399
Beschrijving
Principal Investigator: John Allman, PhD, California Institute of Technology, Pasadena, CA, USA MeSH: Autism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000609 RNA-Seq studies of Gene Expression in Cells and Networks in FI (fronto-insular) and AC (anterior cingulate) cortex in Autism. We seek to understand the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well described autism versus age and sex matched neurotypical individuals. We have investigated two specific cortical areas involved in self-awareness and social reciprocity which are abnormal in autism and have found increased expression in a network of genes related to inflammation in autism group A, whereas the remaining cases, autism group B, have increased expression in a network of genes related to synapses. The current dbGaP study release includes RNA sequencing and phenotype data of n=27 subjects of African - American, Caucasian, or Hispanic origin.
Link
Trefwoorden
Versies (1)
- 15-11-22 15-11-22 - Simon Heim
Houder van rechten
John Allman, PhD, California Institute of Technology, Pasadena, CA, USA
Geüploaded op
15 november 2022
DOI
Voor een aanvraag inloggen.
Licentie
Creative Commons BY 4.0
Model Commentaren :
Hier kunt u commentaar leveren op het model. U kunt de tekstballonnen bij de itemgroepen en items gebruiken om er specifiek commentaar op te geven.
Itemgroep Commentaren voor :
Item Commentaren voor :
U moet ingelogd zijn om formulieren te downloaden. AUB inloggen of schrijf u gratis in.
dbGaP phs000609 RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
Subject - Consent - Affection Status Information
Similar models
Subject - Consent - Affection Status Information
C1257890 (UMLS CUI [1,2])
C0242481 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])