ID

45399

Descripción

Principal Investigator: John Allman, PhD, California Institute of Technology, Pasadena, CA, USA MeSH: Autism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000609 RNA-Seq studies of Gene Expression in Cells and Networks in FI (fronto-insular) and AC (anterior cingulate) cortex in Autism. We seek to understand the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well described autism versus age and sex matched neurotypical individuals. We have investigated two specific cortical areas involved in self-awareness and social reciprocity which are abnormal in autism and have found increased expression in a network of genes related to inflammation in autism group A, whereas the remaining cases, autism group B, have increased expression in a network of genes related to synapses. The current dbGaP study release includes RNA sequencing and phenotype data of n=27 subjects of African - American, Caucasian, or Hispanic origin.

Link

dbGaP study = phs000609

Palabras clave

Versiones (1)

1. 15/11/22 15/11/22 - Simon Heim

Titular de derechos de autor

John Allman, PhD, California Institute of Technology, Pasadena, CA, USA

Subido en

15 de noviembre de 2022

DOI

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Licencia