ID
45399
Description
Principal Investigator: John Allman, PhD, California Institute of Technology, Pasadena, CA, USA MeSH: Autism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000609 RNA-Seq studies of Gene Expression in Cells and Networks in FI (fronto-insular) and AC (anterior cingulate) cortex in Autism. We seek to understand the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well described autism versus age and sex matched neurotypical individuals. We have investigated two specific cortical areas involved in self-awareness and social reciprocity which are abnormal in autism and have found increased expression in a network of genes related to inflammation in autism group A, whereas the remaining cases, autism group B, have increased expression in a network of genes related to synapses. The current dbGaP study release includes RNA sequencing and phenotype data of n=27 subjects of African - American, Caucasian, or Hispanic origin.
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- 11/15/22 11/15/22 - Simon Heim
Copyright Holder
John Allman, PhD, California Institute of Technology, Pasadena, CA, USA
Uploaded on
November 15, 2022
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Creative Commons BY 4.0
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dbGaP phs000609 RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
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