ID
45394
Descrição
Principal Investigator: Stephen Warren, PhD, Emory University, Atlanta, GA, USA MeSH: Autistic Disorder,Autism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000619 Autism is a common disorder whose causes are poorly understood. Both genetic and environmental influences are thought to act together causing autism. Epigenetics is an area that bridges genetic and environmental influencing and commonly is studied by examining dynamic methylation changes to the DNA. We have screened a total of 78 autistic boys and their fathers by this method in 807 genes and find 116 methylation changes that together can correctly identify nearly 80% of the affected boys from their fathers. We propose to confirm these exciting data in a much larger set of genes in 1,200 autistic boys and their families, including unaffected brothers. These data not only could provide new insight into the causes of autism but could also result in a screening test for autism.
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- 15/11/2022 15/11/2022 - Simon Heim
Titular dos direitos
Stephen Warren, PhD, Emory University, Atlanta, GA, USA
Transferido a
15 de novembro de 2022
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs000619 Epigenetic Marks as Peripheral Biomarkers of Autism
Subject - Consent - Affection Status Information
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