ID
45393
Description
Principal Investigator: Arul M. Chinnaiyan, MD, PhD, University of Michigan, MI, USA MeSH: Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000525 In this study, we describe a systematic analysis of pseudogene 'transcription' from an RNA-Seq resource of 293 samples, from 13 cancer and normal tissue types. We observed a highly prevalent, genome-wide expression of pseudogenes that could be categorized as universally expressed or lineage- and/or cancer-specific. We also explored disease subtype specificity and functions of selected expressed pseudogenes. We provide evidence that transcribed pseudogenes are a significant contributor to the transcriptional landscape of cells and are positioned to play significant roles in cellular differentiation and cancer progression. Our work provides a transcriptome resource that enables high-throughput analyses of pseudogene expression.
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- 11/15/22 11/15/22 - Simon Heim
Copyright Holder
Arul M. Chinnaiyan, MD, PhD, University of Michigan, MI, USA
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November 15, 2022
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License
Creative Commons BY 4.0
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dbGaP phs000525 Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers
Subject ID, consent group, subject source, subject source ID, and affection status of participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
- StudyEvent: SEV1
- Subject ID, consent group, subject source, subject source ID, and affection status of participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
- Sample ID, analyte type, tumor status, alias name of samples, and body site where samples were obtained from participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
Similar models
Subject ID, consent group, subject source, subject source ID, and affection status of participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
- StudyEvent: SEV1
- Subject ID, consent group, subject source, subject source ID, and affection status of participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
- Sample ID, analyte type, tumor status, alias name of samples, and body site where samples were obtained from participants involved in the "Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers" project.
C1257890 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C0681850 (UMLS CUI [1,3])
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])