ID
45385
Description
Principal Investigator: Patrick Brown, MD, PhD, Stanford University, HHMI, Stanford, CA, USA MeSH: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000522 Few genetic drivers of children with hyperdiploid precursor B-cell acute lymphoblastic leukemia (ALL) have been identified to date. In an effort to detect novel genomic rearrangements that could be promoting leukemogenesis in this subset of patients, we sequenced ribosomal RNA-depleted transcriptomes isolated from 5 hyperdiploid acute lymphoblastic leukemia samples. In addition to looking for novel genomic rearrangements, we also sought to identify transcripts that could be created as a result of a novel posttranscriptional process. Surprisingly, we identified transcripts created as the result of exon circularization. The results of our studies are present in the paper "Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types" published in PLoS ONE (PMID: 22319583).
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Mots-clés
Versions (1)
- 11/11/2022 11/11/2022 - Chiara Middel
Détendeur de droits
Patrick Brown, MD, PhD, Stanford University, HHMI, Stanford, CA, USA
Téléchargé le
11 novembre 2022
DOI
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Licence
Creative Commons BY 4.0
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dbGaP phs000522 Hyperdiploid Acute Lymphoblastic Leukemia RNA-Seq
This data table contains subject IDs and consent group information of subjects with hyperdiploid acute lymphoblastic leukemia.
- StudyEvent: SEV1
- This data table contains subject IDs and consent group information of subjects with hyperdiploid acute lymphoblastic leukemia.
- The data table contains mapping of study subject IDs to sample IDs of subjects with hyperdiploid acute lymphoblastic leukemia. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. Sample use is also included.
- The sample attributes data table includes sample analyte type (DNA or RNA), body site where samples were collected, is tumor status, and histological type.
Similar models
This data table contains subject IDs and consent group information of subjects with hyperdiploid acute lymphoblastic leukemia.
- StudyEvent: SEV1
- This data table contains subject IDs and consent group information of subjects with hyperdiploid acute lymphoblastic leukemia.
- The data table contains mapping of study subject IDs to sample IDs of subjects with hyperdiploid acute lymphoblastic leukemia. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. Sample use is also included.
- The sample attributes data table includes sample analyte type (DNA or RNA), body site where samples were collected, is tumor status, and histological type.