ID

45376

Description

Principal Investigator: Nada Abumrad, PhD, Washington University School of Medicine, St. Louis, MO, USA MeSH: Hypobetalipoproteinemias https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000561 Hypobetalipoproteinemia is characterized by extremely low levels of low-density lipoprotein cholesterol. Familial hypobetalipoproteinemia (FHBL) is a monogenic form of hypobetalipoproteinemia caused by mutations in the APOB gene. There are cases of hypobetalipoproteinemia not caused by mutations in APOB, however. The purpose of this study is to identify novel genetic causes of hypobetalipoproteinemia.

Link

dbGap-study=phs000561

Keywords

  1. 11/4/22 11/4/22 - Chiara Middel
Copyright Holder

Nada Abumrad, PhD, Washington University School of Medicine, St. Louis, MO, USA

Uploaded on

November 4, 2022

DOI

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License

Creative Commons BY 4.0

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dbGaP phs000561 Metabolism and Genetics of Hypobetalipoproteinemia

Eligibility Criteria

Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Cases included in the study have hypobetalipoproteinemia and at least one affected first degree relative.
Description

Elig.phs000561.v1.p1.1

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0020597
UMLS CUI [1,3]
C1517194
UMLS CUI [1,4]
C0522476
Controls included in the study are relatives without hypobetalipoproteinemia
Description

Elig.phs000561.v1.p1.2

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C1517194
UMLS CUI [1,4]
C0522477

Similar models

Eligibility Criteria

Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
Elig.phs000561.v1.p1.1
Item
Cases included in the study have hypobetalipoproteinemia and at least one affected first degree relative.
boolean
C1512693 (UMLS CUI [1,1])
C0020597 (UMLS CUI [1,2])
C1517194 (UMLS CUI [1,3])
C0522476 (UMLS CUI [1,4])
Elig.phs000561.v1.p1.2
Item
Controls included in the study are relatives without hypobetalipoproteinemia
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C1517194 (UMLS CUI [1,3])
C0522477 (UMLS CUI [1,4])

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