ID
45311
Descripción
Principal Investigator: Gary Curhan, MD, ScD, FASN Professor of Medicine, Harvard Medical School, Channing Laboratory/Renal Division Brigham and Women's Hospital , Boston, MA USA MeSH: Nephrolithiasis,Urolithiasis,Kidney Calculi,Hypercalciuria,Hyperoxaluria https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000460 Genetic and environmental factors play an important role in the etiology of nephrolithiasis. This project will build on and extend our previous efforts (examining environmental risk factors for stone formation) by allowing us to study the risk of stone formation associated with specific genes and gene-environment interactions. We will take advantage of previously collected data in three large cohort studies: Nurses' Health Study I (n=121,000 women), Nurses' Health Study II (n=116,000 women), and Health Professionals Follow-up Study (n=51,000 men). Over a period of 17 to 26 years, information has been collected prospectively on important exposures including diet, family history, body size measures, past medical history, and medications. We have confirmed over 2000 incident cases of kidney stones in each cohort (DK59583, PI Curhan). Further, we have collected 24-hour urine samples from over 4100 stone formers and non-stone formers; the majority of participants have performed two collections. The primary objective of this project is to examine the association between single nucleotide polymorphisms and the 24-hour urinary excretion of stone promoters (calcium and oxalate) and a stone inhibitor (citrate). The secondary objective is to explore the impact of interactions between the genetic factors and dietary factors on 24-hour urinary excretion of relevant lithogenic factors. These findings should provide new insight into regulation of these important factors and also into novel approaches for prevention of stone formation.
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Versiones (1)
- 23/10/2022 23/10/2022 - Adrian Schulz
Titular de derechos de autor
Gary Curhan, MD, ScD, FASN Professor of Medicine, Harvard Medical School, Channing Laboratory/Renal Division Brigham and Women's Hospital , Boston, MA USA
Subido en
23 octobre 2022
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs000460 Genome wide association study of 24 hour urine composition in the Nurses' Health Study, Nurses' Health Study II, and the Health Professionals Follow-Up Study
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent groups of participants with or without kidney stones and involved in the " Genetics of 24 hour urine composition " project.
- Sample ID, subject ID, and sample use variables obtained from participants with or without kidney stones and involved in the " Genetics of 24 hour urine composition " project.
- Subject ID, age, gender, sex, laboratory tests of urine including measurement of calcium, oxalate, citrate, uric acid, sodium, potassium, magnesium, phosphorus, sulfate, creatinine, pH, calcium oxalate, brushite, family history of kidney stone, and body mass index of participants with or without kidney stone and involved in the "Genetics of 24 hour urine composition" project.
- Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without kidney stones and involved in the "Genetics of 24 hour urine composition" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent groups of participants with or without kidney stones and involved in the " Genetics of 24 hour urine composition " project.
- Sample ID, subject ID, and sample use variables obtained from participants with or without kidney stones and involved in the " Genetics of 24 hour urine composition " project.
- Subject ID, age, gender, sex, laboratory tests of urine including measurement of calcium, oxalate, citrate, uric acid, sodium, potassium, magnesium, phosphorus, sulfate, creatinine, pH, calcium oxalate, brushite, family history of kidney stone, and body mass index of participants with or without kidney stone and involved in the "Genetics of 24 hour urine composition" project.
- Sample ID, body site where sample was collected, analyte type, tumor status of sample, and histological type of sample obtained from participants with or without kidney stones and involved in the "Genetics of 24 hour urine composition" project.
C0680251 (UMLS CUI [1,2])