ID
45299
Descripción
Principal Investigator: Steven R. Cummings, MD, San Francisco Coordinating Center, California Pacific Medical Center, Research Institute, CA, USA MeSH: Osteoporosis,Osteoarthritis,Sleep https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000510 *The Study of Osteoporotic Fractures (SOF)* is a prospective multicenter study of risk factors for vertebral and non vertebral fractures. The cohort is comprised of 9704 community-dwelling women 65 years old or older recruited from populations-based listings in four U.S. areas: Baltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; and the Monongahela Valley, Pennsylvania. Women enrolled in the study were 99% Caucasian with African American women initially excluded from the study due to their low incidence of hip fractures. (A cohort of AA women was recruited at the 6th Visit.) The SOF participants were followed up every four months by postcard or telephone to ascertain the occurrence of falls, fractures and changes in address. To date, follow-up rates have exceeded 95% for vital status and fractures. All fractures are validated by x-ray reports or in the case of most hip fractures, a review of pre-operative radiographs. Blood samples were collected in 6795 women at their Year 2 exam (Visit 2) and with written consent for use of DNA in genetic studies. Of these, we have GWAS data on 3625 Caucasian participants. As a separate study, the SOF Osteoarthritis Project was funded separately to collect data about risk factors for osteoarthritis (OA) and analyze baseline hip and hand films for the presence and severity of OA. Raw GWAS data is housed at the study's coordinating center and not released as part of the dbGaP release. The raw data can be requested from the study's coordinating center. Only QC cleaned PLINK files are available at dbGaP. Auxiliary files are also available for duplicates and HapMap participants.
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Versiones (1)
- 19/10/22 19/10/22 - Adrian Schulz
Titular de derechos de autor
Steven R. Cummings, MD, San Francisco Coordinating Center, California Pacific Medical Center, Research Institute, CA, USA
Subido en
19 de octubre de 2022
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs000510 Study of Osteoporotic Fractures (SOF)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table includes subject IDs, consent group information, and subject aliases.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs and sample aliases. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotypes data table includes participants who have completed questionnaires regarding medical history, medications, physical activity, diet, alcohol intake, and cigarette smoking. Objective measures of anthropometric, neuromuscular, vision, strength, and cognitive variables were obtained at a clinic visit. Skeletal assessments included DEXA of the total hip, femoral neck and lumbar spine, calcaneal ultrasound, and vertebral radiographs. Radiographic prevalent and incident vertebral (baseline to visit 3) fractures were assessed. Sleep characteristics were assessed in a subcohort with actigraphy and polysomnography. Radiographic hip osteoarthritis was measured using hip X-rays collected at the SOF baseline visit and a modified Croft summary grade for radiographic hip OA (RHOA) severity of 0 - 4 was assigned to each hip based on individual radiographic features. Both SOF and MrOS data contain harmonized variables with the prefix HA to allow sex differences to be evaluated.
- This sample attributes data table includes body site where sample was collected, analyte type, and tumor status.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table includes subject IDs, consent group information, and subject aliases.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs and sample aliases. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotypes data table includes participants who have completed questionnaires regarding medical history, medications, physical activity, diet, alcohol intake, and cigarette smoking. Objective measures of anthropometric, neuromuscular, vision, strength, and cognitive variables were obtained at a clinic visit. Skeletal assessments included DEXA of the total hip, femoral neck and lumbar spine, calcaneal ultrasound, and vertebral radiographs. Radiographic prevalent and incident vertebral (baseline to visit 3) fractures were assessed. Sleep characteristics were assessed in a subcohort with actigraphy and polysomnography. Radiographic hip osteoarthritis was measured using hip X-rays collected at the SOF baseline visit and a modified Croft summary grade for radiographic hip OA (RHOA) severity of 0 - 4 was assigned to each hip based on individual radiographic features. Both SOF and MrOS data contain harmonized variables with the prefix HA to allow sex differences to be evaluated.
- This sample attributes data table includes body site where sample was collected, analyte type, and tumor status.
C1512693 (UMLS CUI [1,2])