ID
45295
Beskrivning
Principal Investigator: Antonio Iavarone, MD, Columbia University, New York, NY, USA MeSH: Glioblastoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000505 We used massively parallel, paired-end sequencing of expressed transcripts (RNA-seq) to detect novel gene fusions in short-term cultures of glioma stem-like cells freshly isolated from nine patients carrying primary glioblastoma multiforme (GBM). The culture of primary GBM tumors under serum-free conditions selects cells that retain phenotypes and genotypes closely mirroring primary tumor profiles as compared to serum-cultured glioma cell lines that have largely lost their developmental identities.
Länk
Nyckelord
Versioner (2)
- 2022-10-16 2022-10-16 - Tabea Kampen
- 2022-10-17 2022-10-17 - Dr. Christian Niklas
Rättsinnehavare
Antonio Iavarone, MD, Columbia University, New York, NY, USA
Uppladdad den
17 oktober 2022
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs000505 Gene Fusion Discovery through RNA Sequencing of Human Glioblastoma Stem Cell Lines
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This data table contains subject IDs and consent group information.
- The data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- The sample attributes data table includes sample type, body site where sample was extracted, sample analyte type and histological type.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This data table contains subject IDs and consent group information.
- The data table contains mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- The sample attributes data table includes sample type, body site where sample was extracted, sample analyte type and histological type.
C0017636 (UMLS CUI [2,1])
C0011900 (UMLS CUI [2,2])
C0598934 (UMLS CUI [3,1])
C1533691 (UMLS CUI [3,2])
C0038250 (UMLS CUI [3,3])