ID
45267
Description
Principal Investigator: Vincent Young, MD PhD, University of Michigan, Ann Arbor, MI, USA MeSH: Pouchitis,Inflammatory Bowel Diseases,Colitis, Ulcerative https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000262 The aims of the multi-center Ulcerative Colitis Human Microbiome Project (UCHMP) are to examine the role of the enteric microbiome in causing human ulcerative colitis, specifically the development of pouchitis. Pouchitis is an inflammatory condition of the surgically-created ileoanal pouch that serves as a pseudo-rectum in patients with ulcerative colitis who have undergone a total colectomy. It is a condition unique to ulcerative colitis (UC), as it rarely occurs in non-UC patients who have the same procedure. Within one year, about 50% of patients will develop pouchitis. The condition is almost certainly due to aspects of the pouch microbiota on a background of genetic susceptibility, as most patients respond to treatment with antibiotics. While there have been reports on the microbiota in pouchitis patients, all have been performed after the inflammatory process is initiated, rendering interpretation of the results difficult, as the inflammatory process itself will change the microbiota. *Our project is therefore unique and possibly the only opportunity in the role of the enteric microbiome in IBD in a prospective manner, thereby establishing potentially important causal relationships between microbiota structure or function and development of UC.*The studies also offer two additional advantages. First, the development of the pouch microbiota can be observed prospectively. Second, the cause of antibiotic treatment failure in some patients with pouchitis may be revealed. The two aims are (1) to identify causal factors in the structure and/or function of the enteric microbiota in the development of pouchitis, and (2) to determine the basis of treatment failure in UC pouchitis patients. Our analyses will include serial measurements of enteric microbial structure (16S rRNA gene-based), function (metagenomics and functional candidate genes), and cultivation, the latter to enhance interpretation of gene sequences derived from metagenomes and targeted gene surveys (either functional or 16S genes). The insights gained from these studies will help us understand the fundamental and causative roles of the enteric microbiome in human inflammatory bowel diseases (IBD). This information will be the basis for developing strategies to restore host-microbial relationships to prevent and treat IBD.
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Versions (2)
- 07/06/2022 07/06/2022 - Dr. Christian Niklas
- 12/10/2022 12/10/2022 - Adrian Schulz
Détendeur de droits
Vincent Young, MD PhD
Téléchargé le
12 octobre 2022
DOI
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Licence
Creative Commons BY 4.0
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dbGaP phs000262 The Role of the Gut Microbiota in Ulcerative Colitis
Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- Subject ID, sample ID, sample source, source sample ID, and sample use of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- Subject ID, age, race, gender, post-IPAA paucities, and tobacco usage by participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- Sample ID, analyte type, body site where sample was obtained, histological type of sample, inflammation status, tumor status of sample, paucities disease activity index, sequence center, and visit of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
Similar models
Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- Subject ID, sample ID, sample source, source sample ID, and sample use of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- Subject ID, age, race, gender, post-IPAA paucities, and tobacco usage by participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
- Sample ID, analyte type, body site where sample was obtained, histological type of sample, inflammation status, tumor status of sample, paucities disease activity index, sequence center, and visit of participants with or without ulcerative colitis and involved in the "Ulcerative Colitis Human Microbiome Project (UCHMP)" project.
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,3])
C0009932 (UMLS CUI [1,2])
C1698493 (UMLS CUI [1,3])