ID
45257
Description
Principal Investigator: James J. Goedert, M.D., National Institutes of Health, Bethesda, MD, USA MeSH: HIV,Hemophilia A https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000445 Rare individuals are highly resistant to infection with human immunodeficiency virus (HIV). Studies of candidate genes resulted in the discovery of a 32bp deletion in the CC-chemokine receptor 5 gene (CCR5Δ32), which rendered this critical co-receptor for primary HIV infection to be non-functional. Pharmacologic and vaccine-induced blockade of CCR5 is being pursued to treat and prevent HIV infection and other conditions. The allele frequency of CCR5Δ32 among persons of European ancestry is approximately 10%. CCR5Δ32/Δ32 homozygotes are almost totally resistant to HIV infection. People with severe hemophilia A require frequent replacement with clotting Factor VIII (FVIII) to control hemorrhage. Prior to the discovery of HIV in 1984 and licensure of recombinant FVIII in the late 1980s, people with severe hemophilia A were treated with plasma-derived FVIII and thus were intensively exposed to HIV. Only 5% of such patients were not infected with HIV. Of these, approximately 1/3 were CCR5Δ32/Δ32 homozygotes. The remaining 2/3 of these people who were highly resistant to HIV remain unexplained. This project seeks to discover genome variations among people who are highly resistant to HIV infection. Such variation is likely to serve as a target for reducing the morbidity and incidence of HIV.
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Mots-clés
Versions (2)
- 29/06/2022 29/06/2022 - Dr. Christian Niklas
- 12/10/2022 12/10/2022 - Adrian Schulz
Détendeur de droits
James J. Goedert, M.D., National Institutes of Health, Bethesda, MD, USA
Téléchargé le
12 octobre 2022
DOI
Pour une demande vous connecter.
Licence
Creative Commons BY 4.0
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dbGaP phs000445 HIV-Resistant People with Hemophilia
Sample ID, analyte type [DNA], body site where from samples were collected, status of samples [tumor or normal tissue], and histological type of samples obtained from patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- Sample ID, subject ID, and sample use variables associated with patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- Subject ID, sex, and race of patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- Sample ID, analyte type [DNA], body site where from samples were collected, status of samples [tumor or normal tissue], and histological type of samples obtained from patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
Similar models
Sample ID, analyte type [DNA], body site where from samples were collected, status of samples [tumor or normal tissue], and histological type of samples obtained from patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- Sample ID, subject ID, and sample use variables associated with patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- Subject ID, sex, and race of patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
- Sample ID, analyte type [DNA], body site where from samples were collected, status of samples [tumor or normal tissue], and histological type of samples obtained from patients highly resistant or susceptible to human immunodeficiency virus (HIV) infection and involved in the "Genome Variation among HIV-Resistant People with Hemophilia" project.
C2346787 (UMLS CUI [1,2])
C0200345 (UMLS CUI [1,2])
C2347029 (UMLS CUI [1,2])
C0040300 (UMLS CUI [2,1])
C2347029 (UMLS CUI [2,2])
C0332307 (UMLS CUI [1,2])