ID

45241

Descrição

Principal Investigator: Nenad Sestan, Yale University School of Medicine, New Haven, CT, USA MeSH: Growth and Development,Aging https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000406 Comprehensive knowledge about the spatiotemporal dynamics of the brain transcriptome is essential for a better understanding of neurodevelopment, sexual dimorphism, and evolution, as well as our increased susceptibility to certain brain disorders. We generated and analyzed genome-wide exon-level transcriptome data from 16 brain regions of 57 postmortem human brains, spanning from embryonic development to late adulthood and representing males and females of multiple ethnicities. We also performed genome-wide genotyping of 2.5 million SNPs and assessed genome normality for all donors. This study provides a comprehensive, publicly available dataset on the spatiotemporal human brain transcriptome and new insights into the transcriptional foundations of human neurodevelopment.

Link

dbGaP study = phs000406

Palavras-chave

Versões (2)
  1. 13/07/2022 13/07/2022 - Dr. Christian Niklas
  2. 12/10/2022 12/10/2022 - Adrian Schulz
Titular dos direitos

Nenad Sestan, Yale University School of Medicine, New Haven, CT, USA

Transferido a

12 de outubro de 2022

DOI

Para um pedido faça login.

Licença

Creative Commons BY 4.0
Comentários do modelo :

Aqui pode comentar o modelo. Pode comentá-lo especificamente através dos balões de texto nos grupos de itens e itens.

Voltar para os comentários do modelo
Comentários do grupo de itens para :

Comentários do item para :

Para descarregar formulários, precisa de ter uma sessão iniciada. Por favor faça login ou registe-se gratuitamente.

dbGaP phs000406 Spatiotemporal Transcriptome of the Human Brain

Inglês

Eligibility Criteria

6 Formulários  
Inclusion and exclusion criteria
Descrição

Inclusion and exclusion criteria

All selected subjects are normal according to following criteria:
Descrição

All selected subjects are normal according to following criteria

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0681850
UMLS CUI [1,3]
C0460094
Subjects with chromosomal or large-scale genomic abnormalities, detected by karyogram and/or Illumina Human Omni-2.5, were excluded.
Descrição

Subjects with chromosomal or large-scale genomic abnormalities, detected by karyogram and/or Illumina Human Omni-2.5, were excluded.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0008625
UMLS CUI [1,3]
C1704258
UMLS CUI [1,4]
C0887950
Prenatal and neonatal specimens were excluded if drug or alcohol abuse by the mother during pregnancy was reported or if potassium chloride, salt water, or urea were injected into the amniotic sac during surgical procedure.
Descrição

Prenatal and neonatal specimens were excluded if drug or alcohol abuse by the mother during pregnancy was reported or if potassium chloride, salt water, or urea were injected into the amniotic sac during surgical procedure

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0370003
UMLS CUI [1,3]
C0678804
UMLS CUI [1,4]
C2939425
UMLS CUI [1,5]
C0013146
UMLS CUI [1,6]
C0001948
UMLS CUI [1,7]
C0026591
UMLS CUI [1,8]
C0347984
UMLS CUI [1,9]
C0032961
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0370003
UMLS CUI [2,3]
C0678804
UMLS CUI [2,4]
C2939425
UMLS CUI [2,5]
C1272883
UMLS CUI [2,6]
C0883994
UMLS CUI [2,7]
C0032825
UMLS CUI [2,8]
C0036082
UMLS CUI [2,9]
C0041942
UMLS CUI [2,10]
C0347984
UMLS CUI [2,11]
C0543467
Only brains free of obvious malformations or lesions were collected. Disqualifying characteristics included any obvious abnormality of the neural tube, forebrain, brainstem, cranial nerves, cerebellum, or spinal cord.
Descrição

Only brains free of obvious malformations or lesions were collected.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1704258
UMLS CUI [1,3]
C3714787
Samples were excluded if microscopic analysis revealed extensive neuronal loss, neuronal swelling, glioneuronal heterotopias, or dysmorphic neurons and neurites.
Descrição

Samples were excluded if microscopic analysis revealed extensive neuronal loss, neuronal swelling, glioneuronal heterotopias, or dysmorphic neurons and neurites.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C2678195
UMLS CUI [1,3]
C3670503
UMLS CUI [1,4]
C0266491
UMLS CUI [1,5]
C5194942
UMLS CUI [1,6]
C0432072
UMLS CUI [1,7]
C0085103
Samples that tested positive for Hepatitis B, Hepatitis C, or HIV were excluded.
Descrição

Samples that tested positive for Hepatitis B, Hepatitis C, or HIV were excluded.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0019693
UMLS CUI [1,3]
C0019163
UMLS CUI [1,4]
C0019196
Early postnatal and adult (periods 8-15) specimens were excluded if excessive drug or alcohol abuse was reported, if the individual had any known neurological or psychiatric disorders, or if any prolonged agonal conditions were reported.
Descrição

Early postnatal and adult (periods 8-15) specimens were excluded if excessive drug or alcohol abuse was reported, if the individual had any known neurological or psychiatric disorders, or if any prolonged agonal conditions were reported.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0038586
UMLS CUI [1,3]
C0004936
UMLS CUI [1,4]
C0027765
UMLS CUI [1,5]
C0262926
UMLS CUI [1,6]
C0439590
UMLS CUI [1,7]
C0030193
Voltar ao início da página

Similar models

Eligibility Criteria

6 Formulários
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Inclusion and exclusion criteria
All selected subjects are normal according to following criteria
Item
All selected subjects are normal according to following criteria:
boolean
C1512693 (UMLS CUI [1,1])
C0681850 (UMLS CUI [1,2])
C0460094 (UMLS CUI [1,3])
Subjects with chromosomal or large-scale genomic abnormalities, detected by karyogram and/or Illumina Human Omni-2.5, were excluded.
Item
Subjects with chromosomal or large-scale genomic abnormalities, detected by karyogram and/or Illumina Human Omni-2.5, were excluded.
boolean
C0680251 (UMLS CUI [1,1])
C0008625 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C0887950 (UMLS CUI [1,4])
Prenatal and neonatal specimens were excluded if drug or alcohol abuse by the mother during pregnancy was reported or if potassium chloride, salt water, or urea were injected into the amniotic sac during surgical procedure
Item
Prenatal and neonatal specimens were excluded if drug or alcohol abuse by the mother during pregnancy was reported or if potassium chloride, salt water, or urea were injected into the amniotic sac during surgical procedure.
boolean
C0680251 (UMLS CUI [1,1])
C0370003 (UMLS CUI [1,2])
C0678804 (UMLS CUI [1,3])
C2939425 (UMLS CUI [1,4])
C0013146 (UMLS CUI [1,5])
C0001948 (UMLS CUI [1,6])
C0026591 (UMLS CUI [1,7])
C0347984 (UMLS CUI [1,8])
C0032961 (UMLS CUI [1,9])
C0680251 (UMLS CUI [2,1])
C0370003 (UMLS CUI [2,2])
C0678804 (UMLS CUI [2,3])
C2939425 (UMLS CUI [2,4])
C1272883 (UMLS CUI [2,5])
C0883994 (UMLS CUI [2,6])
C0032825 (UMLS CUI [2,7])
C0036082 (UMLS CUI [2,8])
C0041942 (UMLS CUI [2,9])
C0347984 (UMLS CUI [2,10])
C0543467 (UMLS CUI [2,11])
Only brains free of obvious malformations or lesions were collected.
Item
Only brains free of obvious malformations or lesions were collected. Disqualifying characteristics included any obvious abnormality of the neural tube, forebrain, brainstem, cranial nerves, cerebellum, or spinal cord.
boolean
C0680251 (UMLS CUI [1,1])
C1704258 (UMLS CUI [1,2])
C3714787 (UMLS CUI [1,3])
Samples were excluded if microscopic analysis revealed extensive neuronal loss, neuronal swelling, glioneuronal heterotopias, or dysmorphic neurons and neurites.
Item
Samples were excluded if microscopic analysis revealed extensive neuronal loss, neuronal swelling, glioneuronal heterotopias, or dysmorphic neurons and neurites.
boolean
C0680251 (UMLS CUI [1,1])
C2678195 (UMLS CUI [1,2])
C3670503 (UMLS CUI [1,3])
C0266491 (UMLS CUI [1,4])
C5194942 (UMLS CUI [1,5])
C0432072 (UMLS CUI [1,6])
C0085103 (UMLS CUI [1,7])
Samples that tested positive for Hepatitis B, Hepatitis C, or HIV were excluded.
Item
Samples that tested positive for Hepatitis B, Hepatitis C, or HIV were excluded.
boolean
C0680251 (UMLS CUI [1,1])
C0019693 (UMLS CUI [1,2])
C0019163 (UMLS CUI [1,3])
C0019196 (UMLS CUI [1,4])
Early postnatal and adult (periods 8-15) specimens were excluded if excessive drug or alcohol abuse was reported, if the individual had any known neurological or psychiatric disorders, or if any prolonged agonal conditions were reported.
Item
Early postnatal and adult (periods 8-15) specimens were excluded if excessive drug or alcohol abuse was reported, if the individual had any known neurological or psychiatric disorders, or if any prolonged agonal conditions were reported.
boolean
C0680251 (UMLS CUI [1,1])
C0038586 (UMLS CUI [1,2])
C0004936 (UMLS CUI [1,3])
C0027765 (UMLS CUI [1,4])
C0262926 (UMLS CUI [1,5])
C0439590 (UMLS CUI [1,6])
C0030193 (UMLS CUI [1,7])
Voltar ao início da página 

Contacto

Use este formulário para feedback, perguntas e sugestões de aperfeiçoamento.

Campos marcados com * são obrigatórios.

Ajuda

Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

Watch Tutorial