Information:
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ID
45228
Description
Principal Investigator: MeSH: Major Depressive Disorder https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000020 Identification of genomic regions that confer susceptibility to or protection from major depressive disorder (MDD) via genomewide association. *Consent groups and participant set* - Psychiatric and Related Somatic Conditions (PRSC): 3741 (1821 cases, 1822 controls, 98 others)
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Versions (2)
- 7/26/22 7/26/22 - Martin Dugas
- 10/12/22 10/12/22 - Adrian Schulz
Copyright Holder
Patrick F. Sullivan, University of North Carolina, Chapel Hill, NC, USA
Uploaded on
October 12, 2022
DOI
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License
Creative Commons BY 4.0
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dbGaP phs000020 Major Depression: Stage 1 Genomewide Association in Population-Based Samples
Eligibility Criteria
- StudyEvent: 44968_dbGaP phs000020 Major Depression: Stage 1 Genomewide Association in Population-Based Samples
- Eligibility Criteria
- The data table contains diagnostic phenotype data which provide the basis for diagnosis of major depressive disorder according to the Composite Interview Diagnostic Interview (CIDI): Depressive Disorder section (n=3 variables). Data has been collected from the Amsterdam Biographic Survey (ABV) for neuroticism (n=31 variables) and somatic complaints (n=18 variables), Beck Depression Invetory (BDI) for depression symptoms (n=14 variables), Beck Anxiety Inventory (BAI) for clinical anxiety (n=22 variables), Inventory of Depressive Symptoms (IDS) for psychometric properties (n=31 variables), NEO-FFI for neuroticism (n=13 variables), YASR Anxious Depression Survey from 1991, 1995, 1997, 2000, and 2002 (n=65 variables), and Spielberger Trait Anxiety Inventory (STAI, n=21 variables). Basic sociodemographic variables (n=7 variables), and family history of major depression (n=1 variable), and environmental factors (n=2 variables) are included.
- The data table includes the variable for the number of major depressive disorder episodes according to the Composite Interview Diagnostic Interview (CIDI): Depressive Disorder section.
- The data table contains a complete listing of subjects and consent group.
Similar models
Eligibility Criteria
- StudyEvent: 44968_dbGaP phs000020 Major Depression: Stage 1 Genomewide Association in Population-Based Samples
- Eligibility Criteria
- The data table contains diagnostic phenotype data which provide the basis for diagnosis of major depressive disorder according to the Composite Interview Diagnostic Interview (CIDI): Depressive Disorder section (n=3 variables). Data has been collected from the Amsterdam Biographic Survey (ABV) for neuroticism (n=31 variables) and somatic complaints (n=18 variables), Beck Depression Invetory (BDI) for depression symptoms (n=14 variables), Beck Anxiety Inventory (BAI) for clinical anxiety (n=22 variables), Inventory of Depressive Symptoms (IDS) for psychometric properties (n=31 variables), NEO-FFI for neuroticism (n=13 variables), YASR Anxious Depression Survey from 1991, 1995, 1997, 2000, and 2002 (n=65 variables), and Spielberger Trait Anxiety Inventory (STAI, n=21 variables). Basic sociodemographic variables (n=7 variables), and family history of major depression (n=1 variable), and environmental factors (n=2 variables) are included.
- The data table includes the variable for the number of major depressive disorder episodes according to the Composite Interview Diagnostic Interview (CIDI): Depressive Disorder section.
- The data table contains a complete listing of subjects and consent group.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
cases
Item
MDD cases were recruited through mental health care organizations, general practices and in the community setting (for details see Boomsma et al. 2007; in press). The inclusion criteria for the 1780 participants are: 1) a DSM-IV diagnosis of major depressive disorder as confirmed by the CIDI psychiatric interview, 2) an age between 18 through 65 years, 3) sufficient knowledge of the Dutch language, and 4) North-european ancestry. As the samples should be representative of patients seen in different settings, there are few a priori exclusion criteria. Excluded patients are: 1) those with a primary diagnosis of psychosis, bipolar disorder, obsessive compulsive disorder, severe addiction disorder and 2) those with insufficient knowledge of the Dutch language.
boolean
C3274647 (UMLS CUI [1,1])
controls
Item
For age and gender matched control subjects are mainly derived from the Netherlands Twin Register, for which data collection in twin, their parents, spouses and siblings occurred in 1991, 1993, 1995, 1997, 2000, 2002/3 and 2004/5. A total of 1860 controls were selected (only one member from each family) with the following inclusion criteria: 1) age 18 through 65 years, 2) never scoring high (> 0.65) on a general factor score for anxious depression (a combined measure of neuroticism, anxiety and depressive symptoms via questionnaires, Boomsma et al., 2000), 3) never reported a history of MDD in any survey, and 4) North-european ancestry. Controls and their parents were born in the Netherlands or northwestern Europe.
boolean
C3274648 (UMLS CUI [1,1])