ID

45222

Descripción

Principal Investigator: Thomas Quertermous, Stanford University, Palo Alto, CA, USA MeSH: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000423 ADVANCE (Atherosclerotic Disease, VAscular functioN, and genetiC Epidemiology) is a large epidemiological study of genetic and non-genetic determinants of coronary artery disease (CAD) that started in 2000 as a collaborative effort between researchers at Stanford University and Kaiser Permanente of Northern California. The overarching goal of the study is to improve our ability to prevent, diagnose and treat CAD. The initial study included recruitment of over 3600 subjects (including 1873 subjects with incident clinically significant coronary disease and 1745 control subjects) from multiple race/ethnic backgrounds. A subset of ~ 500 subjects with very early onset coronary disease (men 45 and women 55) and ~ 500 similar aged controls were genotyped using the Illumina 550K platform as part of an NIH funded effort within the STAMPEED consortium.

Link

dbGaP study = phs000423

Palabras clave

Versiones (3)
  1. 29/7/22 29/7/22 - Simon Heim
  2. 12/10/22 12/10/22 - Adrian Schulz
  3. 29/1/25 29/1/25 - Akane Nishihara
Titular de derechos de autor

Thomas Quertermous, Stanford University, Palo Alto, CA, USA

Subido en

12 de octubre de 2022

DOI

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Licencia

Creative Commons BY 4.0
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dbGaP phs000423 GWAS for Early Onset Coronary Disease (ADVANCE)

Inglés

Eligibility Criteria

1 formularios  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
Inclusion and exclusion criteria
Descripción

Inclusion and exclusion criteria

**Cases**
Descripción

Cases

Tipo de datos

boolean

*Inclusion*
Descripción

Inclusion

Tipo de datos

boolean

Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.
Descripción

Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0455539
Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females
Descripción

Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0001779
*Exclusion*
Descripción

Exclusion

Tipo de datos

boolean

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Descripción

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0010068
UMLS CUI [1,4]
C0006826
UMLS CUI [1,5]
C1623038
UMLS CUI [1,6]
C0035078
UMLS CUI [1,7]
C0029216
UMLS CUI [1,8]
C0005961
A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.
Descripción

A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C2984077
UMLS CUI [1,4]
C0564215
UMLS CUI [1,5]
C0584993
UMLS CUI [1,6]
C0376245
**Controls**
Descripción

Controls

Tipo de datos

boolean

*Young Controls from Kaiser*
Descripción

Young Controls from Kaiser

Tipo de datos

boolean

*Inclusion*
Descripción

Inclusion

Tipo de datos

boolean

Membership in KPNC continuously since 1/1/1998
Descripción

Membership in KPNC continuously since 1/1/1998

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0680038
Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females
Descripción

Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0001779
Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California
Descripción

Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C2316883
*Exclusion*
Descripción

Exclusion

Tipo de datos

boolean

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Descripción

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0010068
UMLS CUI [1,4]
C0019682
UMLS CUI [1,5]
C0497327
UMLS CUI [1,6]
C0006826
UMLS CUI [1,7]
C1623038
UMLS CUI [1,8]
C0035078
UMLS CUI [1,9]
C5549095
UMLS CUI [1,10]
C3846158
A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.
Descripción

A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C2984077
UMLS CUI [1,4]
C0564215
UMLS CUI [1,5]
C0584993
UMLS CUI [1,6]
C0376245
*Young Controls from CARDIA*
Descripción

Young Controls from CARDIA

Tipo de datos

boolean

*Inclusion*
Descripción

Inclusion

Tipo de datos

boolean

Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.
Descripción

Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0239307
UMLS CUI [1,4]
C0085756
UMLS CUI [1,5]
C0205411
UMLS CUI [1,6]
C0444245
*Exclusion*
Descripción

Exclusion

Tipo de datos

boolean

A personal history of clinically significant CAD or documented CAD by CARDIA investigators
Descripción

A personal history of clinically significant CAD or documented CAD by CARDIA investigators

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C1956346
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Similar models

Eligibility Criteria

1 formularios
  1. StudyEvent: SEV1
    1. Eligibility Criteria
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
Inclusion and exclusion criteria
Cases
Item
**Cases**
boolean
Inclusion
Item
*Inclusion*
boolean
Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.
Item
Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0455539 (UMLS CUI [1,3])
Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females
Item
Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Exclusion
Item
*Exclusion*
boolean
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Item
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0010068 (UMLS CUI [1,3])
C0006826 (UMLS CUI [1,4])
C1623038 (UMLS CUI [1,5])
C0035078 (UMLS CUI [1,6])
C0029216 (UMLS CUI [1,7])
C0005961 (UMLS CUI [1,8])
A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.
Item
A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C2984077 (UMLS CUI [1,3])
C0564215 (UMLS CUI [1,4])
C0584993 (UMLS CUI [1,5])
C0376245 (UMLS CUI [1,6])
Controls
Item
**Controls**
boolean
Young Controls from Kaiser
Item
*Young Controls from Kaiser*
boolean
Inclusion
Item
*Inclusion*
boolean
Membership in KPNC continuously since 1/1/1998
Item
Membership in KPNC continuously since 1/1/1998
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0680038 (UMLS CUI [1,3])
Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females
Item
Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California
Item
Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C2316883 (UMLS CUI [1,3])
Exclusion
Item
*Exclusion*
boolean
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Item
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0010068 (UMLS CUI [1,3])
C0019682 (UMLS CUI [1,4])
C0497327 (UMLS CUI [1,5])
C0006826 (UMLS CUI [1,6])
C1623038 (UMLS CUI [1,7])
C0035078 (UMLS CUI [1,8])
C5549095 (UMLS CUI [1,9])
C3846158 (UMLS CUI [1,10])
A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.
Item
A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C2984077 (UMLS CUI [1,3])
C0564215 (UMLS CUI [1,4])
C0584993 (UMLS CUI [1,5])
C0376245 (UMLS CUI [1,6])
Young Controls from CARDIA
Item
*Young Controls from CARDIA*
boolean
Inclusion
Item
*Inclusion*
boolean
Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.
Item
Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0239307 (UMLS CUI [1,3])
C0085756 (UMLS CUI [1,4])
C0205411 (UMLS CUI [1,5])
C0444245 (UMLS CUI [1,6])
Exclusion
Item
*Exclusion*
boolean
A personal history of clinically significant CAD or documented CAD by CARDIA investigators
Item
A personal history of clinically significant CAD or documented CAD by CARDIA investigators
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C1956346 (UMLS CUI [1,3])
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