ID
45215
Beskrivning
Principal Investigator: Raymond Cho, MD, PhD, University of California San Francisco School of Medicine, San Francisco, CA, USA MeSH: Carcinoma, Squamous Cell https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000418 The earliest genetic abnormalities in cancer represent a unique opportunity for timely clinical diagnosis. Classic deep sequencing of tumors identifies many aberrations acquired later in cancer progression. In this study, data regarding simple mutation and chromosomal aberration were integrated to trace the evolution of cutaneous squamous cell carcinomas and ovarian adenocarcinomas. Only after the second allele of TP53 was lost did the genome enter a window of extreme genomic vulnerability, in both cancer types, eventually acquiring more than 100,000 mutations in skin cancers. Inactivating Notch mutations were also identified as prevalent secondary changes. These results add context to the idea of TP53 mutation as dominant negative and occurring later in tumorigenesis.
Länk
Nyckelord
Versioner (2)
- 2022-08-01 2022-08-01 - Adrian Schulz
- 2022-10-12 2022-10-12 - Adrian Schulz
Rättsinnehavare
Raymond Cho, MD, PhD, University of California San Francisco School of Medicine, San Francisco, CA, USA
Uppladdad den
12 oktober 2022
DOI
För en begäran logga in.
Licens
Creative Commons BY 4.0
Modellkommentarer :
Här kan du kommentera modellen. Med hjälp av pratbubblor i Item-grupperna och Item kan du lägga in specifika kommentarer.
Itemgroup-kommentar för :
Item-kommentar för :
Du måste vara inloggad för att kunna ladda ner formulär. Var vänlig logga in eller registrera dig utan kostnad.
dbGaP phs000418 Temporal Dissection of Tumorigenesis in Primary Cancers
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, subject source ID, and affection status of participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
- Subject ID, age, birthplace, sex, race, and unknown height, education, and weight of participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
- Sample ID, body site where from sample was collected, analyte type [DNA], tumor status [Y/N], histological type of tumor [squamous cell carcinoma], tumor stage and grade [N/A], and treatment [surgical excision] obtained from participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, subject source ID, and affection status of participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
- Subject ID, age, birthplace, sex, race, and unknown height, education, and weight of participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
- Sample ID, body site where from sample was collected, analyte type [DNA], tumor status [Y/N], histological type of tumor [squamous cell carcinoma], tumor stage and grade [N/A], and treatment [surgical excision] obtained from participants with squamous cell carcinoma of skin and involved in the "Temporal Dissection of Tumorigenesis in Primary Cancers" project.
C1512693 (UMLS CUI [1,2])