ID

45207

Beschreibung

Principal Investigator: David Carey, PhD, Weis Center for Research, Geisinger Clinic, Danville, PA, USA MeSH: Abdominal Aortic Aneurysms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000387 A large research cohort of Geisinger Abdominal Aortic Aneurysm (AAA) patients was created by enrolling and consenting patients of the Geisinger Department of Vascular Surgery. Consented patients provide blood, serum and DNA samples for research and authorize use of data in their medical record for research. They also complete a data questionnaire that asks information about family history of AAA and other vascular diseases, as well as information on known or suspected AAA risk factors, including smoking history, body mass index, hypertension, type 2 diabetes, and atherosclerotic disease. The AAA cases are 78% male, with a mean age of 74 years; 39% have undergone surgical or endovascular repair; more than 85% or current or past smokers; approximately 20% of cases report a positive family history of AAA. Geisinger AAA patients undergo regular imaging studies, typically every 6 months, to monitor the progression of aneurysm expansion. This allows the growth rates of their aneurysm to be calculated. DNA samples from a total of 910 AAA patients were used for whole genome genotyping; these results are included in the dbGaP.

Link

dbGaP study = phs000387

Stichworte

Versionen (2)
  1. 04.08.22 04.08.22 - Simon Heim
  2. 12.10.22 12.10.22 - Adrian Schulz
Rechteinhaber

David Carey, PhD, Weis Center for Research, Geisinger Clinic, Danville, PA, USA

Hochgeladen am

12. Oktober 2022

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs000387 Geisinger eMERGE - Abdominal Aortic Aneurysm Project (AAAP)

Englisch

Eligibility Criteria

5 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Inclusion criteria: An individual was eligible for participation in this study if they were an adult meeting the following criteria: 1) Is a Geisinger Clinic patient; 2) Consented to participate in the Geisinger AAA biobanking project (these include condition-specific criteria, e.g. patient meeting clinical criteria for abdominal aortic aneurysm); and 3) the consent for the Geisinger biobanking project included linking the samples to the subject's electronic health information and was broad enough to allow genetic association studies.
Beschreibung

Inclusion criteria: An individual was eligible for participation in this study if they were an adult meeting the following criteria: 1) Is a Geisinger Clinic patient; 2) Consented to participate in the Geisinger AAA biobanking project (these include condition-specific criteria, e.g. patient meeting clinical criteria for abdominal aortic aneurysm); and 3) the consent for the Geisinger biobanking project included linking the samples to the subject's electronic health information and was broad enough to allow genetic association studies.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1547115
UMLS CUI [1,3]
C0021430
Exclusion criteria: Dementia that precludes informed consent.
Beschreibung

Exclusion criteria: Dementia that precludes informed consent.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0497327
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Ähnliche Modelle

Eligibility Criteria

5 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
Inclusion criteria: An individual was eligible for participation in this study if they were an adult meeting the following criteria: 1) Is a Geisinger Clinic patient; 2) Consented to participate in the Geisinger AAA biobanking project (these include condition-specific criteria, e.g. patient meeting clinical criteria for abdominal aortic aneurysm); and 3) the consent for the Geisinger biobanking project included linking the samples to the subject's electronic health information and was broad enough to allow genetic association studies.
Item
Inclusion criteria: An individual was eligible for participation in this study if they were an adult meeting the following criteria: 1) Is a Geisinger Clinic patient; 2) Consented to participate in the Geisinger AAA biobanking project (these include condition-specific criteria, e.g. patient meeting clinical criteria for abdominal aortic aneurysm); and 3) the consent for the Geisinger biobanking project included linking the samples to the subject's electronic health information and was broad enough to allow genetic association studies.
boolean
C1512693 (UMLS CUI [1,1])
C1547115 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
Exclusion criteria: Dementia that precludes informed consent.
Item
Exclusion criteria: Dementia that precludes informed consent.
boolean
C0680251 (UMLS CUI [1,1])
C0497327 (UMLS CUI [1,2])
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