ID
45197
Description
Principal Investigator: Gerard D. Schellenberg, PhD, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA MeSH: Alzheimer Disease,Dementia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000372 The National Institute on Aging (NIA) Alzheimer's Disease Centers (ADCs) cohort includes subjects ascertained and evaluated by the clinical and neuropathology cores of the 29 NIA-funded ADCs. Data collection is coordinated by the National Alzheimer's Coordinating Center (NACC). NACC coordinates collection of phenotype data from the 29 ADCs, cleans all data, coordinates implementation of definitions of AD cases and controls, and coordinates collection of samples. The ADC cohort consists of autopsy-confirmed and clinically-confirmed AD cases, and cognitively normal elders (CNEs) with complete neuropathology data who were older than 60 years at age of death, and living CNEs evaluated using the Uniform dataset (UDS) protocol who were documented to not have mild cognitive impairment (MCI) and were between 60 and 100 years of age at assessment. ADCs sent frozen tissue from autopsied subjects and DNA samples from some autopsied subjects and from living subjects to the National Cell Repository for Alzheimer's Disease (NCRAD). DNA was prepared by NCRAD for genotyping and sent to the genotyping site at Children's Hospital of Philadelphia. ADC samples were genotyped and analyzed in separate batches. [Reprinted from AC Naj et al. Common variants at *MS4A4/MS4A6E*, *CD2AP*, *CD33* and *EPHA1* are associated with late-onset Alzheimer's disease. *Nature Genetics* 43, 436-441 (2011). doi:10.1038/ng.801. PMID: 21460841.]
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Versions (2)
- 8/18/22 8/18/22 - Simon Heim
- 10/12/22 10/12/22 - Adrian Schulz
Copyright Holder
Gerard D. Schellenberg, PhD, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
Uploaded on
October 12, 2022
DOI
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License
Creative Commons BY 4.0
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dbGaP phs000372 ADGC Genome Wide Association Study
Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, subject source, subject source ID, consent group, and affection status of participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- Subject ID, sex, race, Hispanic or not Hispanic origin, affection status, age at onset, age at last visit, age at death, APOE genotype, and genotype platform of participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- Sample ID, analyte type, tumor status of sample, and body site where sample was obtained from participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
Similar models
Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, subject source, subject source ID, consent group, and affection status of participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- Subject ID, sex, race, Hispanic or not Hispanic origin, affection status, age at onset, age at last visit, age at death, APOE genotype, and genotype platform of participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
- Sample ID, analyte type, tumor status of sample, and body site where sample was obtained from participants with or without Alzheimer's disease and involved in the "Alzheimer's Disease Genetics Consortium (ADGC) Genome Wide Association Study -NIA Alzheimer's Disease Centers Cohort" project.
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,3])